Seminars list
 Tuesday, September 10th, 2024 - Seminar Speaker(s) : Mauro Gaya (Centre d'Immunologie de Marseille Luminy ), Mariolina Salio (Immunocore LTD, Abingdon UK) B cell memory in barrier tissues - " From the bench to the bedside: cancer immunotherapy with soluble T cell receptors"B cell memory in barrier tissues During infection, the immune system unleashes protective responses to fight against the pathogen while also establishes a memory compartment that will provide protection in case of a subsequent pathogen encounters. The B cell memory compartment is composed of t... |
 Tuesday, September 10th, 2024 - Seminar Speaker(s) : Victor Sourjik Physical limits to bacterial motility and its evolutionary optimizationAlthough all biological systems must obey the laws of physics, specific examples of physical limitations on the performance of biological systems remain sparce. Bacterial motility is among the quantitatively best-understood biological behaviors, and it has long served as a model of how physics ca... |
 Wednesday, September 11th, 2024 - Seminar Speaker(s) : Yoël Forterre From perception to action without nerves and muscles: lessons from plantsAs sessile organisms, plants face a constantly changing environment with no means of escape. Thus, despite their lack of nerves and muscles, they have evolved unique mechanisms to perceive and respond to external physical signals. In this seminar, I will illustrate this ability through two emblem... |
 Monday, September 16th, 2024 - Seminar Immunology series Speaker(s) : Enfu Hui (Department of Cell and Developmental Biology, UCSD, San Diego) When Nuance Matters: The lesser known side of PD1 signalingThe inhibitory immunoreceptor PD1 is a major cancer immunotherapy target. Anti-PD1 blockade antibodies have become the standard of care for cancer patients, but the low response rate and associated immune related side effects necessitate a better understanding of PD1 mechanism. Best known to be e... |
 Monday, September 16th, 2024 - Institutional seminar "Mayent - Rothschild" Speaker(s) : Eran Meshorer (Department of Genetics, The Institute of Life Science & The Edmond and Lily Safra Center for Brain Sciences (ELSC), The Hebrew University of Jerusalem) Epigenetics: from human pluripotent stem cell models of neurodegenerative diseases to recent human evolutionIn the first part, I will discuss juvenile and infantile forms of human pluripotent stem cell (hPSC) isogenic models for Huntington's disease (HD), the most common poly-glutamine (polyQ) related disorder. HD is caused by CAG (encoding glutamine, Q) expansions within the Huntingtin (HTT) gene. The... |
 Wednesday, September 18th, 2024 - Seminar Speaker(s) : Pierre Nassoy Engineering, Sorting, Inflating multicellular balloonsOrganoids are lumen-containing multicellular structures that recapitulate key features of the organs. We will first present a microfluidic technology that allows to produce them at high throughput in individual hydrogel capsules. Next, we will show how we can sort cellular aggregates according to... |
Tracing the protection mechanisms against mammary tumour initiation.Oncogenic mutations are abundant in tissues of healthy individuals, but rarely form tumours. Yet, the underlying protection mechanisms are largely unknown. To resolve these mechanisms in murine mammary tissue, we use lineage tracing to map the fate of wild-type and Brca1−/−;Trp53&minu... |
New Insights into the Vertebrate Head through Lineage Tracing and Single Cell ApproachesDespite apparent differences between humans and fish, our biological similarities are more profound than commonly recognized. This presentation explores how zebrafish research yields valuable insights into developmental processes, tissue functions, and models for human congenital disorders. Our r... |
 Monday, September 23rd, 2024 - Seminar Speaker(s) : Thomas Pradeu (CNRS) Why immunologists have no other choice but to do conceptual & theoretical immunologyIn this talk, I argue that immunologists who do not think conceptually and theoretically are very unlikely to make useful contributions to their own field. In a first part, I make three points. First, theories have been crucial in immunology since its inception at the end of the 19th century. Se... |
Use of advanced human lung culture models to study effects of radiotherapyPulmonary radiation toxicity is a main dose-limiting factor of radiotherapy for lung cancer, and manifests primarily as radiation-induced pneumonitis and fibrosis. A variety of mechanisms have been implicated in this toxicity, with a central role of DNA damage following radiation and formation of... |
Morphology meets Genomics Evolution of development in flies , beetles and spidersUnderstanding the evolutionary forces shaping the breathtaking morphological diversity present in nature is one prerequisite to describe and maintain this biodiversity. Linking genetic variation to phenotypic differences is a crucial step towards this goal because information about the appearance... |
RNA-binding proteins in cancer: lessons from CSDE1"RNA-binding proteins (RBPs) modulate all aspects of post-transcriptional gene expression and are increasingly recognized as essential for cancer cell adaptation, reprogramming and stress survival. We aim to identify novel vulnerabilities of metastatic cells that could be harnessed for cancer tre... |
Hands-on tour of the single cell analysis journey, from cloud to loupe to community-developed toolsIn this seminar, you will be introduced to the single cell gene expression analysis journey. Analysis begins at experimental design. Together we will explore a set of neutrophil data starting with the 10x Cloud Analysis platform for raw data processing. From there, we will assess the data quality... |
Shaping the genome with SMC motorsHow are the meters of DNA inside our cells organised in 3D to allow key chromosomal processes to take place in the correct manner? Key to this organisation are the SMC motors cohesin and condensin. But how do these molecular machines actually do what they do? And how are they regulated such that ... |
 Wednesday, October 2nd, 2024 - Seminar Speaker(s) : David Brückner Self-organization and information flow in multicellular systemsA key feature of many developmental systems is their ability to self-organize spatial patterns of functionally distinct cell fates. A spectacular example of this ability are artificial stem cell assemblies, which are paving the way towards a quantifiable self-organization of biological systems. H... |
 From Monday, September 30th, 2024 To Friday, October 4th, 2024 - International Course Seminar Spatial multimodal data analysis: when omics meet images (Computational Systems Biology of Cancer)The course will gather leading speakers from different fields in cancer systems biology, in cancer research and in clinics. The invited speakers will expose various approaches for omics, imaging, clinical data analysis and interpretation, combining signalling networks together with multi-scale mo... |
 Monday, October 7th, 2024 - Seminar Speaker(s) : Luca Magnani (Institute of Cancer Research) Breast Cancer Dormancy: A Link to the PastLuca Magnani graduated from his bachelor's and master's degree at the University of Bologna. During an exchange visit to Purdue University, he discovered his interest in early embryogenesis. Dr. Magnani's work took him to Michigan State University, where he continued his research on mouse embryog... |
 Tuesday, October 8th, 2024 - Institutional seminar "Mayent - Rothschild" Speaker(s) : Eran Meshorer (Department of Genetics, The Institute of Life Science & The Edmond and Lily Safra Center for Brain Sciences (ELSC), The Hebrew University of Jerusalem) Epigenetics: from pluripotent stem cells to ancient DNAPluripotent embryonic stem cells (ESCs) are characterized by a unique, globally decondensed, chromatin structure. In the first and main part will describe our endogenously-tagged fluorescent-fusion protein libraries in mouse ESCs, which we used to screen for potential regulators of pluripotency a... |
Endocytic control of cell plasticity in cancerOver the past two decades, there has been a significant shift in our understanding of the role of endocytosis and trafficking of signaling receptors. It has evolved from being viewed simply as a signal extinguisher (resulting in long-term attenuation) to being recognized as a sophisticated mechan... |
 Wednesday, October 16th, 2024 - Seminar Journée cancer du sein et cancers gynécologiquesLe Groupe Sein de l'Institut Curie - Hôpital à Saint-Cloud a, comme chaque année, le plaisir de vous inviter à sa demi-journée conscrée aux cancers de la femme, dans le but de présenter et de discuter ensemble les aspects pratiques de la prise en charge et l'évolution des connaissances dans ce do... |
 From Monday, October 14th, 2024 To Friday, October 18th, 2024 - International Course Seminar 6th International Breast Cancer Course - From Clinics to BiologyThis 6th edition of the international breast cancer course organized by the Institut Curie offers a comprehensive overview of current topics on clinical and biological aspects of breast cancer. This course brings together internationally renowned experts who will present the latest innovations in... |
Protein structure and membrane dynamics in the endolysosomal system. |
 Monday, October 28th, 2024 - Seminar Immunology series Speaker(s) : Michel Desjardins (Département de pathologie et biologie cellulaire from Université de Montréal) Auto immune mechanisms in Parkinsons diseaseThe loss of dopaminergic neurons during Parkinson's disease (PD) is responsible for the hallmark motor impairment associated with the disease. The molecular mechanisms driving the disease process are still poorly understood. While the contribution of inflammation in PD is well established, a grow... |
 From Monday, October 21st, 2024 To Wednesday, October 30th, 2024 - International Course Seminar Developmental Biology: from stem cells to morphogenesis - 15th editionInstitut Curie and Sorbonne Université organize their 15th International Developmental Biology course. The aim of the program is to provide the participants a comprehensive coverage of the paradigms, problems and technologies of modern Developmental Biology paying particular attention to stem ... |
Crystal ribcage: a platform for probing real-time lung function at cellular resolution in health and diseaseUnderstanding the dynamic pathogenesis and treatment response in pulmonary diseases requires probing the lung at cellular resolution in real-time. Despite recent progress in intravital imaging, optical imaging of the lung during active respiration and circulation has remained challenging. Here, I... |
Immune-brain communication at the choroid plexusIt is now accepted that blood-derived immune cells and microbial products shape brain development, function, aging, and disease, yet the presence of such factors in the brain territory is limited. So how can they exert their powerful effect on the nervous system from afar? The choroid plexus (... |
 From Tuesday, November 12th, 2024 To Friday, November 15th, 2024 - International Course Seminar Advanced Course on Immunity and Cancer Immunotherapy 2024The Immunity and Cancer Unit of Institut Curie (INSERM U932) is organizing the 7th edition of the Advanced Course on Immunity and Cancer Immunotherapy. In the context of ongoing cooperation projects with research teams in Chile and Argentina that have resulted in the prior organization of work... |
 From Tuesday, November 12th, 2024 To Friday, November 15th, 2024 - International Course Seminar Advanced Course on Immunity and Cancer Immunotherapy 2024The Immunity and Cancer Unit of Institut Curie (INSERM U932) is organizing the 7th edition of the Advanced Course on Immunity and Cancer Immunotherapy. In the context of ongoing cooperation projects with research teams in Chile and Argentina that have resulted in the prior organization of work... |
 Wednesday, March 12th, 2025 - Seminar Speaker(s) : Thorsten Hugel Compartment-specific protein dynamics and signalling in living cells revealed by smFRETProteins in cells are not homogeneously distributed, but often localized to specific compartments, which may or may not be enclosed by membranes. Here I will first discuss the dynamic formation of membraneless compartments in the non-equilibrium environment of living cells and how this formati... |