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  • Lundi 4 Septembre 2017 - Séminaire Immunology series Orateur(s) : Maria Rescigno (European Institute of Oncology and University of Milan, Italy)

    Interaction of the mucosal immune system with the microbiota

    The microbiota is emerging as an important environmental factor influencing several functions of our body. Many disorders have been associated to a disequilibrium of the microbiota that is called dysbiosis., these include not only gut disorders as inflammatory bowel disease and colorectal cancer,...

  • Lundi 4 Septembre 2017 - Séminaire Orateur(s) : Max Gottesman MD PhD (Columbia University, New York, USA)

    Coupling and Uncoupling Transcription with Translation

    We show that transcription and translation are physically coupled in E.coli by the NusG protein. The NTD of NusG binds RNAP, whereas its CTD binds ribosomal protein S10. We present a cryo-EM structure showing NusG CTD bound to S10 in an intact 70S ribosome. We find that NusG is required for coupl...

  • Mardi 5 Septembre 2017 - Séminaire Nuclear dynamic series Orateur(s) : Abby DERNBURG (Department of >Molecular & Cell Biology, University of California, Berkeley (CA, USA))

    A liquid crystalline interface between chromosomes controls meiotic recombination

    Dr. Dernburg's lab is interested in meiosis, the special division process by which the genetic information on chromosomes is transmitted from parent to progeny through sexual reproduction. Errors in this process lead to aneuploidy and are a major cause of human birth defects such as Down syndrome...

  • Lundi 11 Septembre 2017 - Séminaire Orateur(s) : Shane Crotty (La Jolla Institute for Allergy & Immunology (LJI), La Jolla, CA, USA)

    Assessing the engines of affinity maturation to vaccines: germinal centers and Tfh cells

    T cell help to B cells was one of the earliest discovered functions of T cells, 49 years ago, resulting in the coining of the term ‘helper cell'. Follicular helper T cells (Tfh) are the specialized CD4 T cells for B cell help. Generation of long term humoral immunity is a complex process pr...

  • Lundi 11 Septembre 2017 - Séminaire institutionnel "Mayent - Rothschild" Orateur(s) : Yves Pommier (Center for Cancer Research, National Cancer Institute, NIH)

    Precision Medicine and DNA-Targeted Agents

          

  • Mardi 12 Septembre 2017 - Séminaire Orateur(s) : Philippe JAY (Institute of Functional Genomics, Montpellier)

    Tuft cells : intestinal epithelial sentinels linking luminal danger to immune responses

    - Gerbe F., Sidot E., Smyth D. J., Ohmoto M., Matsumoto I., Dardalhon V., Cesses P., Garnier L., Pouzolles M., Brulin B., Bruschi M., Harcus Y., Zimmermann V. S., Taylor N., Maizels R. M. and Jay P. : Intestinal epithelial tuft cells initiate type 2 mucosal responses to helminth parasites. Nature...

  • Jeudi 14 Septembre 2017 - Séminaire CDC Orateur(s) : Edgar GOMES (Institute of Molecular Medicine (IMM), Lisbon, Portugal)

    Positioning the nucleus for cell function

    Connecting the nucleus to the cytoskeleton is relevant for multiple cellular processes and disruption of these connections result in multiple pathologies. Nuclear positioning within cell cytoplasm requires de connection between nucleus and the cytoskeleton. We are interesting to understand the pr...

  • Jeudi 14 Septembre 2017 - Séminaire Orateur(s) : Patrick Rochette (Centre de Recherche du CHU de Québec – Université Laval, Québec, Canada)

    Ultraviolet A-induced oxidation in the cornea: short and long-term effects

    Human eye is directly exposed to solar ultraviolet (UV) radiations but the retina is protected from those rays. Indeed, the cornea and the lens filter UV rays to protect the retina against their toxicity. The UVA component represents 95% of solar UV radiation and has photo-oxidant properties. How...

  • Lundi 18 Septembre 2017 - Symposium Orateur(s) : Symposium in memory of Dr. Ethel Moustacchi

    "DNA repair, Repair syndromes and Radiation biology" - Symposium in memory of Dr. Ethel Moustacchi

    The symposium DNA repair, Repair syndromes and Radiation Biology is a tribute to the memory of Ethel Moustacchi. Her name is undoubtedly linked to the Institut Curie that is why this symposium will take place in our premises. The symposium will cover the research themes to which Ethel Moustac...

  • Mardi 19 Septembre 2017 - Séminaire Orateur(s) : Carolyn J. BROWN (Department of Medical Genetics, University of British Columbia)

    Making two equal one: Human X-chromosome inactivation

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  • Jeudi 21 Septembre 2017 - Séminaire Orsay series Orateur(s) : Didier GASPARUTTO (SyMMES / UMR 5819 CEA-CNRS-Université Grenoble Alpes)

    Ingénierie de l’ADN, des altérations du polymère aux nanoarchitectures bio-inspirées

    L'ADN, molécule dépositaire du message génétique et support de l'hérédité, est soumis quotidiennement à l'agression par des agents exogènes ou endogènes. Ces altérations génétiques, directement liées au processus de mutagenèse, sont également associées au vieillissement et impliquées dans les phé...

  • Mercredi 27 Septembre 2017 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Hans Clevers (Hubrecht Institute, Utrecht, the Netherlands)

    Stem cell-grown organoids as models for human disease

    The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. We originally defined Lgr5 as a Wnt target gene, transcribed in colon cancer cells. Two knock-in alleles revealed exclusive expression of Lgr5 in cycling, columnar cells at the crypt base. Using lineage tracing e...

  • Lundi 9 Octobre 2017 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Jürgen Knoblich (Institute of Molecular Biotechnology (IMBA), Vienna, Austria)

    Neural stem cells and brain development: From Drosophila to humans

    The human brain is the most fascinating and most complex organ of all. Despite this enormous complexity, the billions of neurons in our brain arise from a limited number of progenitors following a specific set of lineage decisions. We combine Drosophila genetics with 3D organoid cultures derived ...

  • Mardi 10 Octobre 2017 - Mini-colloquium

    “Book Marking” & Mitotic/Meiotic Inheritance

    Organised by Danny Reinberg, Howard Hughes Medical Institute, NYU Langone School of Medicine at Smilow Research Center, New York, USA (Sabbatical 2017 - Blaise Pascal Research Chair) With Edith Heard, UMR3215/U934 and Geneviève Almouzni, Dir. Of the Research Center, UMR3664, Institut Curie ...

  • Jeudi 19 Octobre 2017 - Séminaire Orateur(s) : Guillaume Lebon (Institut de Génomique Fonctionnelle, Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Montpellier, F-34000 Montpellier (France).)

    Structural characterisation of G protein-coupled receptors, What have we learnt?

    G Protein Coupled receptors (GPCRs) are integral membrane protein and constitute the largest family of membrane proteins. GPCRs are localised at the plasma membrane of eukaryotic cells. They mediate signal transduction from the extracellular to the intracellular compartment and play an important ...

  • Vendredi 24 Novembre 2017 - Séminaire Orateur(s) : Sara Sigismund (IFOM, Fondazione Istituto FIRC di Oncologia Molecolare)

    ER-PM contact sites control EGFR endocytosis and signaling

    The integration of distinct endocytic routes is critical to regulate receptor signaling. A non-clathrin endocytic pathway (NCE) of the epidermal growth factor receptor (EGFR) is activated at high ligand concentrations, in parallel to clathrin-mediated endocytosis (CME). EGFR-NCE requires receptor...

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