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  • Lundi 26 Juin 2017 - Séminaire Orateur(s) : Martine BEHRA (Department of Anatomy and Neurobiology, San Juan, University of Puerto Rico)

    Tnks1bp1 a novel key player in the maintenance of hair cell progenitors.

    Loss of hair cells (HC), the mechanoreceptors of sensory epithelia of the inner ear, is the major cause of non-syndromic hearing disorders. These sophisticated cells are highly sensitive to several otoxic factors including antibiotics, noise or simply ageing because we are born with a finite stoc...

  • Mardi 27 Juin 2017 - Séminaire Nuclear dynamic series Orateur(s) : Alfonso Fernandez ALVAREZ (NIH/NCI, Bethesda (MD, USA))

    Centromeric control of nuclear envelope disassembly

    Chromosome ‘linearity' is so universal among eukaryotes that we assume it to be evolutionarily advantageous. Nonetheless, formidable challenges are presented by linear chromosome ends, as their resemblance to damage-induced DNA breaks makes them vulnerable to degradation and end-joining pat...

  • Mercredi 28 Juin 2017 - Séminaire CDC Orateur(s) : Frederic BARD (IMCB - A*STAR in Singapore)

    Journey to the Center of the Cell

    How cells receive and interpret signals from the outside world is a key question in biology. Most signalling is thought to occur through cell surface receptors that transduce signals across the cell membrane and connect to cytosolic signalling cascades. At variance with this model, cell surface r...

  • Mercredi 28 Juin 2017 - Séminaire CDC Orateur(s) : Vivek SHENOY

    Cell-Matrix Interactions in Fibrosis and Cancer: Multiscale mechano-chemical models

    Much of our understanding of the biological mechanisms that underlie cellular functions, such as migration, differentiation and force sensing has been garnered from studying cells cultured on two-dimensional (2D) substrates. In the recent years there has been intense interest and effort to unders...

  • Mercredi 28 Juin 2017 - Séminaire institutionnel "Mayent - Rothschild" Orateur(s) : Cécile Fradin (Université McMaster d’Hamilton, Canada)

    How many Bcl-2 family proteins does it take to form a pore in a lipid membrane?

               Proteins from the Bcl-2 family preside over what is essentially the “point-of-no-return” in apoptosis. Pro-apoptotic members of the family promote outer mitochondrial membrane permeabilization and cell death, while anti-apoptotic members promote cell survival by blocking th...

  • Vendredi 30 Juin 2017 - Séminaire Immunology series Orateur(s) : Jason Cyster (Department of Microbiology and Immunology, UCSF, San Francisco (USA))

    Deciphering the guidance cue code for B cell immunity

    Publications : https://www.ncbi.nlm.nih.gov/pubmed/?term=CysterJ Jason Cyster's lab website: http://cysterlab.ucsf.edu/

  • Vendredi 30 Juin 2017 - Séminaire Orateur(s) : Jeremy N. Rich, Julie Pannequin, Emmanuelle Charafe-Jauffret

    Cancer Stem Cell symposium, speakers : Jeremy N. Rich, Julie Pannequin, Emmanuelle Charafe-Jauffret

    Jeremy N. Rich, MD, MHS, MBA. Department of Medicine, Division of Regenerative Medicine, University of California, San Diego, CA 92037 USA "Dynamic Complexity of Glioma Stem Cells"   Julie Pannequin, Institut de Génomique Fonctionnelle, Montpellier, France. "Cancer Stem Cells are Key ...

  • Lundi 3 Juillet 2017 - Séminaire Orateur(s) : Rudy BALLING (Luxembourg Centre for Systems Biomedicine University of Luxembourg)

    From systems biology to systems medicine: Easier said than done

    Systems approaches are increasingly used to dissect the pathogenesis of diseases and to develop new preventive and therapeutic strategies. One of the major challenges is the curation, integration and analysis of heterogenous data, both from the biomedical research as well as the clinical domain. ...

  • Mardi 4 Juillet 2017 - Séminaire Nuclear dynamic series Orateur(s) : Yamini DALAL (NIH/NCI, Bethesda (MD, USA))

    Twisting the dragon's tail: histone variant dynamics in human tumors

    Dr. Dalal's lab focuses on proteins called histones, which package the entirety of the human genome into a nucleoprotein complex called chromatin in vivo. Specific regions of chromatin are prone to fragility and chromosomal rearrangements in cancer cells. Consequently, understanding how this prot...

  • Mercredi 5 Juillet 2017 - Séminaire Curie TechWatch Orateur(s) : Georgia Golfis

    Imaris : The ideal solution to interactively analyze microscopy images

    Bitplane is the world's leading interactive microscopy image analysis software company and was founded in 1992 in Switzerland. Through their constant innovation and a clear focus on 3D and 4D image visualization analysis, Bitplane actively shapes the way scientists process multi-dimensional micro...

  • Jeudi 14 Septembre 2017 - Séminaire CDC Orateur(s) : Edgar GOMES (Institute of Molecular Medicine (IMM), Lisbon, Portugal)

    Positioning the nucleus for cell function

    Connecting the nucleus to the cytoskeleton is relevant for multiple cellular processes and disruption of these connections result in multiple pathologies. Nuclear positioning within cell cytoplasm requires de connection between nucleus and the cytoskeleton. We are interesting to understand the pr...

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