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  • Mardi 20 Février 2018 - Séminaire CDC Orateur(s) : Xavier MORIN (Institut de Biologie Ecole Normale Supérieure (IBENS))

    Asymmetric cell division, Notch signaling and neurogenesis in the vertebrate embryonic spinal cord

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  • Mercredi 21 Février 2018 - Séminaire Orsay series Orateur(s) : Oscar Fernandez-Capetillo (Genomic Instability Group, Spanish National Cancer Research Centre, Spain; Division of Genome Biology, Karolinska Institute, Sweden)

    Coordinating DNA Replication Termination with Mitotic Entry

             G2 is defined as the “growth” phase that follows DNA replication and precedes mitosis. However, recent works have shown examples of uncompleted replication that persists all the way to mitosis, where it leads to chromosomal breakage and genome instability. How or if mechanism...

  • Mardi 27 Février 2018 - Séminaire CDC Orateur(s) : René-Marc MEGE (Institut Jacques Monod, Université Paris Diderot)

    Biogenesis and mechanobiology of adherens junctions

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  • Vendredi 2 Mars 2018 - Séminaire Orateur(s) : Yongmin ZHANG (Université Pierre et Marie Curie-Paris 6)

    Design, synthesis and biological evaluation of carbohydrate derivatives as potential antitumor and antiviral agents

    Glycosphingolipids (GSLs) are components of all animal cell membranes and are involved in many cellular functions including proliferation, adhesion, motility, and differentiation. Ganglioside GM3 (NeuAcα3Galβ4Glcβ1Cer), the first and simplest member in the metabolic series of a GS...

  • Vendredi 2 Mars 2018 - Séminaire Orateur(s) : Dr Diana Passaro, PhD (Haematopoietic Stem Cell Laboratory,The Francis Crick Institute)

    Acute myeloid leukemia associated alteration of the bone marrow microenvironment

    Recent studies have suggested that the initiation and progression of leukemias also depend on their ability to interact with the non-malignant microenvironment, which produces fundamental factors for leukemic cell survival and at the same time adapts to their own needs to promote the progression....

  • Vendredi 2 Mars 2018 - Séminaire Orateur(s) : Ranjan J. Perera Ph.D. (Sanford Burnham Medical Discovery Institute & The Johns Hopkins University)

    The long noncoding RNA SPRIGHTLY (SPRY4-IT1): a new player in different diseases

    Long noncoding RNAs (lncRNAs) were once dismissed as non-functional genomic noise. There is now compelling evidence that lncRNAs play critical roles in human pathophysiology. However, the molecular mechanisms by which the vast majority of lncRNAs regulate their target genes, and proteins remain u...

  • Lundi 5 Mars 2018 - Séminaire Curie TechWatch Orateur(s) : Simon Andrews (Babraham Institute), Felix Krueger (Babraham Institute)

    Developing explorative bioinformatics tools for biologists

    Simon Andrews and Felix Krueger from the Bioinformatics Group at the Babraham Institute will speak about the development of explorative bioinformatics tools. The group developed among others a large array of publicly available tools for analysis of genomics data as Bismark, FastQC, or SNPsplit. M...

  • Mardi 6 Mars 2018 - Séminaire CDC Orateur(s) : Stéphane VASSILOPOULOS (Myologie Centre de Recherche/ Institut de Myologie, G.H. Pitié-Salpêtrière, Paris)

    CLATHRIN PLAQUES FORM MECHANOTRANSDUCING PLATFORMS

    Large flat clathrin lattices, clathrin plaques, are stable features of the plasma membrane observed in several cell types. They have been associated with sites of strong adhesion suggesting that they could also play a role in force transduction. Here, I will present our work on a compartment comp...

  • Vendredi 9 Mars 2018 - Séminaire Orateur(s) : Hakon Leffler (Hakon Leffler Lund University Sect MIG, Inst. Laboratory Medicine Dept. Clinical Immunology, Lund University Hopsital Sölvegatan 23 22362 Lund Sweden)

    Galectins: intra and extracellular functions diagnostic and therapeutic targets in many diseases

    Galectins were discovered in a quest to find proteins binding cell surface carbohydrates and taking part in cell adhesion, and this is indeed one of the roles of galectins. However, they have many other roles. Galectins bind β-galactose containing glycans typically found at the cell surface ...

  • Vendredi 9 Mars 2018 - Séminaire Orateur(s) : Jorge FERREIRA (i3S ¬ - Instituto de Investigação e Inovação em Saúde and Faculdade de Medicina - Universidade do Porto, Portugal)

    Forces and shape changes in cell division

    Accurate chromosome segregation during mitosis requires the efficient assembly of a microtubule-based structure known as the mitotic spindle. To achieve this, most cells rely on centrosomes, which must separate to establish a bipolar geometry and ultimately establish division plane orientation. P...

  • Du Mercredi 7 Mars 2018 Au Mercredi 14 Mars 2018 - Cours international - séminaire

    14th course on Epigenetics

    The aim of this course is to provide an overview of epigenetic mechanisms and their link to chromatin dynamics. The different functions of the nucleus involving the genome and its organization will be discussed with an emphasis on technological limits and the new experimental approaches being dev...

  • Mercredi 14 Mars 2018 - Séminaire Orateur(s) : Bruno Vaz, PhD (CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford)

    Molecular mechanisms of DNA-protein crosslinks repair: Implications for cancer therapy.

    Cells possess an elaborate genome maintenance apparatus, consisting of multiple DNA damage repair (DDR) and DNA damage tolerance pathways. Following DNA damage, sensor proteins recognise the DNA lesions and activate a complex signalling cascade, which marks the genomic region containing the DNA l...

  • Jeudi 15 Mars 2018 - Séminaire Curie TechWatch Orateur(s) : Enrico Mini (University of Florence)

    TRANSCRIPTOMIC AND GERMLINE GENOMIC APPROACHES FOR THE DISCOVERY OF PROGNOSTIC AND PREDICTIVE CANCER BIOMARKERS

    Prediction of prognosis and therapeutic outcome in cancer patients is mostly based on conventional clinical and pathological parameters. However, cancers are biologically heterogeneous diseases and this confers considerable variability in the clinical course independently of stage and other conve...

  • Vendredi 16 Mars 2018 - Séminaire Orateur(s) : Ze’ev Ronai, Ph.D. (Professor and Co-Director, Technion Integrated Cancer Center, Technion, Israel)

    Coordinated regulation of gut microbiome and immune checkpoint activity by the ubiquitin ligase RNF5

    The ubiquitin ligase RNF5 has been implicated in the regulation of ER stress, autophagy and glutamine metabolism. Inoculation of melanoma cells in RNF5 KO mice resulted in limited growth, indicating that lack of RNF5 results in effective inhibition of melanoma development. We found that RNF5 limi...

  • Lundi 19 Mars 2018 - Séminaire Orateur(s) : Morgan HUSE

    Mechanical Control of Cytotoxic T Cell Function

    Cytotoxic T lymphocytes (CTLs) fight viral infections and cancer by selectively recognizing and destroying infected or cancerous target cells.  CTLs kill by forming a specialized interface, known as an immunological synapse, with their target cell, into which they secrete a mixture of toxic prote...

  • Mardi 20 Mars 2018 - Séminaire CDC Orateur(s) : Vincenzo COSTANZO ( IFOM – The FIRC Institute of Molecular Oncology, Milan, Italy)

    Mechanisms of replication fork protection

    For more information: https://www.ifom.eu/en/cancer-research/researchers/vincenzo-costanzo.php and a second link: http://www.armeniseharvard.org/portfolio-articoli/vincenzo-costanzo/

  • Mercredi 21 Mars 2018 - Séminaire Orsay series Orateur(s) : Stéphane Rocchi (INSERM U1065, team 12, Nice, France)

    Identification and characterization of new anti-melanoma compounds

    The melanoma is one of the most lethal cancers among young adults. Melanoma has a high capability of invasion and rapid metastasis to other organs. The prognosis of metastatic melanoma is extremely pejorative. Even if recently encouraging results were obtained with BRAF inhibitors, these response...

  • Du Jeudi 29 Mars 2018 Au Vendredi 30 Mars 2018 - Séminaire Orateur(s) : Richard HOULSTON (Institute of Cancer Research, UK), Paolo VINEIS (Imperial College, UK), Karl MUNGER (Tufts univ., USA), Lluis FAJAS COLL (UNIL, CH), Peter CAMPBELL (Sanger, UK), Luciano DI CROCE (CRG, ES), Christoph PLASS (DFKZ, DE), Stephen BAYLIN (Johns Hopkins, USA), Peter RATCLIFFE (Oxford univ., UK), Thomas BRABLETZ (Erlangen univ., DE), Lucie LAPLANE (IGR, FR), Sylvia FRE (Institut Curie), Peter DIRKS (SickKids, CA), Cedric BLANPAIN (ULB, BEL)

    The origin of cancer : once upon a cell...

    The ADELIH conference is back for the 3rd edition! This year, the conference will take place at Chimie ParisTech on 29-30th March 2018         We will focus on “The origin of cancer: Once upon a cell…” and 4 cancer-related topics have been selected: - Cancer s...

  • Mercredi 18 Avril 2018 - Séminaire Orateur(s) : Sebastian Maurer (CRG – Center for Genomic Regulation, Barcelona, Spain)

    In vitro reconstitution of kinesin-based mRNA transport

    Cytoplasmic mRNA transport along microtubules is an essential mechanism of symmetry breaking, observed in a multitude of biological systems. In neurons, delivery of mRNAs to remote dendritic and axonal locations is essential for neuronal differentiation, axon guidance and synaptic plasticity. Man...

  • Jeudi 19 Avril 2018 - Séminaire Orateur(s) : Alexander AULEHLA (EMBL, Heidelberg)

    Origin and function of synchronized signaling oscillations during embryonic patterning

    Abstract: We study the role of signaling dynamics during embryonic development and hence investigate the function of embryonic clocks, or oscillators. Ultradian oscillations (period ~2 hours) in Wnt, Fgf and Notch signaling pathway activity have been identified in mouse embryos and are linked to ...

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