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  • Mardi 13 Novembre 2018 - Séminaire Cell Biology Series Orateur(s) : Lukas HUBER, PhD

    LAMTOR and BORC regulate the position and size of late endosomes/lysosomes

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  • Mardi 13 Novembre 2018 - Séminaire Orateur(s) : VectorBuilder

    A revolutionary platform for vector design, custom cloning and virus packaging

    VectorBuilder is a revolutionary online platform aimed at providing researchers with one-stop solutions to all their vector design, custom cloning and virus packaging needs. Besides cloning and virus packaging, VectorBuilder offers many other molecular biology services such as BAC modification (r...

  • Mercredi 14 Novembre 2018 - Séminaire Orateur(s) : Eric Schirmer (The Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, and Centre for Translational and Chemical Biology - University of Edinburgh,)

    Nuclear envelope mechanics and genome tethering in gene regulation: constrained diffusion and the lamin spring

    The nuclear envelope (NE) is a complex double membrane system supported by the intermediate filament lamin polymer and many NE transmembrane proteins (NETs) that connect it to both cytoplasmic filaments from the outer nuclear membrane and chromatin from the inner nuclear membrane. These latter co...

  • Mercredi 14 Novembre 2018 - Séminaire Orateur(s) : Eric Schirmer (The Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, and Centre for Translational and Chemical Biology - University of Edinburgh,)

    Nuclear envelope mechanics and genome tethering in gene regulation: constrained diffusion and the lamin spring

    The nuclear envelope (NE) is a complex double membrane system supported by the intermediate filament lamin polymer and many NE transmembrane proteins (NETs) that connect it to both cytoplasmic filaments from the outer nuclear membrane and chromatin from the inner nuclear membrane. These latter co...

  • Mercredi 14 Novembre 2018 - Séminaire Orateur(s) : VectorBuilder

    A revolutionary platform for vector design, custom cloning and virus packaging

    VectorBuilder is a revolutionary online platform aimed at providing researchers with one-stop solutions to all their vector design, custom cloning and virus packaging needs. Besides cloning and virus packaging, VectorBuilder offers many other molecular biology services such as BAC modification (r...

  • Mercredi 14 Novembre 2018 - Séminaire Orateur(s) : Marcus Braun (Institute of Biotechnology Czech Academy of Sciences, Prague, Czech Republic)

    Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymes

    Tau is an intrinsically disordered protein, which diffuses on microtubules. In neurodegenerative diseases collectively termed tauopathies, tau malfunction and its detachment from axonal microtubules is correlated with microtubule degradation. It is known that tau can protect microtubules from mic...

  • Vendredi 16 Novembre 2018 - Séminaire Orateur(s) : Christoph Thiele (Rheinische Friedrich-Wilhelms-Universität, Bonn, Allemagne)

    Multiplexed mass spectrometric lipid metabolic tracing with single cell sensitivity

    Lipid metabolic tracing is a key technology to understand lipid metabolism in health and disease. We have previously demonstrated tracing with picomole sensitivity and lipid class resolution using alkyne-labeled lipids and detection by fluorogenic click reaction combined with TLC separation. To t...

  • Lundi 19 Novembre 2018 - Séminaire Orateur(s) : Martine Roussel (St. Jude Children's Research Hospital, Memphis, USA)

    Pediatric medulloblastoma: Molecular Pathways and Pre-Clinical Trials

    Medulloblastoma (MB) is the most common malignant brain tumor that develops in the cerebellum. MB occurs mostly in children between the ages of 3-7 years. Human MBs are classified into four major subgroups: Wingless (WNT), Sonic Hedgehog (SHH), Group 3 (G3) and G4, each of which has distinct mole...

  • Mardi 20 Novembre 2018 - Séminaire Cell Biology Series Orateur(s) : Ruth KROSCHEWSKI (ETH Zurich - Institute of Biochemistry, Zurich)

    Plasmid DNA transfection, revealing tolerant yet separatist mammalian cells

    The genome of mammalian cells is challenged by extra-chromosomal DNA introduced by viruses, bacteria, or transfection of plasmid DNA. However, how cells handle these DNA molecules is largely unknown. We analyzed predominantly Hela cells stably expressing fluorescently tagged LacI protein and t...

  • Mercredi 21 Novembre 2018 - Séminaire Orateur(s) : David Lacoste (Laboratoire PCT, ESPCI)

    From transient compartmentalization to cell population dynamics

    In the fifties, Oparin imagined liquidlike compartments called  coacervates, which could have played a central role in the origin of life [1]. Although the experimental verification of this idea remained scarce for many years, the idea resurfaced recently in various systems of biological...

  • Lundi 26 Novembre 2018 - Séminaire institutionnel "Mayent - Rothschild" Orateur(s) : Douglas McNeel (Department of Medicine, division of Hematology/Oncology, University of Wisconsin-Madison (USA))

    DNA vaccines as treatment for human prostate cancer – targeting the PD-1/PD-L1 pathway as a major mechanism of resistance

    Prostate cancer has been viewed as an immunologically “cold” tumor, devoid of large numbers of tumor-infiltrating lymphocytes.  We have been interested in vaccines as T-cell activating therapies to ideally augment tumor-specific cytolytic CD8+ T cells as a treatment for early recurren...

  • Mardi 27 Novembre 2018 - Séminaire Orateur(s) : Brendan Evano (Institut Pasteur, Shahragim Tajbahsh’s team), Daniel, Ming Kang Lee (Institut Curie), Justine Marsolier (Institut Curie), Raphaël Rodriguez (Institut Curie)

    Domain 2 Meeting: Genetic and epigenetic regulation of normal and tumorigenic somatic programs

    Brendan Evano (invited by UMR3664, Shahragim Tajbahsh's team); Daniel Ming Kang Lee (UMR3215, Raphaël Margueron's team); Justine Marsolier (UMR3244, Céline Vallot's team); Raphaël Rodriguez (invited, UMR3666, IC Domain 4).

  • Mardi 27 Novembre 2018 - Séminaire Cell Biology Series Orateur(s) : Winnok H. DE VOS, PhD

    NUC-I-LEAKS. EXPOSING THE MECHANISMS THAT COMPROMISE NUCLEAR ENVELOPE INTEGRITY IN HUMAN CANCER CELLS

    The nuclear envelope (NE) has long been considered to dismantle only during mitosis. However, recent observations in cancer cells and laminopathy patient cells have revealed that the NE can also transiently rupture during interphase, thereby perturbing cellular homeostasis and genome stability (1...

  • Mercredi 28 Novembre 2018 - Séminaire Orateur(s) : Patrick O'FARRELL (UCSF, Dept. of Biochemistry and Biophysics)

    Watching embryonic onset of epigenetic programming

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  • Vendredi 30 Novembre 2018 - Symposium

    LifeTime Revolutionizing Healthcare by Tracking and Understanding Human Cells during Disease

    Geneviève Almouzni (Institut Curie / CNRS) et Nikolaus Rajewsky (Max Delbrück Centrer for Molecular Medecine, Helmholtz Association), coordonnent l'initiative LifeTime1, portée par un consortium de dix-huit organisations et un réseau de plus de cinquante prestigieuses institutions européennes et ...

  • Lundi 3 Décembre 2018 - Séminaire Orateur(s) : Rebecca Oakey (King's College, London)

    Rebecca Oakey

    Title & abstract to come.

  • Mardi 4 Décembre 2018 - Séminaire Nuclear dynamic series Orateur(s) : Beatriz VICOSO (Institute of Science and Technology Austria (IST Austria) )

    Evolution of gene dosage on the sex chromosome of schistosome parasites

    XY systems usually have chromosome-wide dosage compensation of X-linked genes (such as the mammalian X-inactivation), whereas in many ZW systems, equalization of expression between the sexes is restricted to a minority of dosage-sensitive genes. Why such differences arose is still unclear. Using ...

  • Lundi 10 Décembre 2018 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Christiane Nüsslein-Volhard

    Marie Curie Seminar: Christiane Nüsslein-Volhard - How fish colour their skin: A paradigm for development and evolution of adult patterns

    Colour patterns are prominent features of most animals; they are highly variable and evolve rapidly leading to large diversities between species even within a single genus. As targets for natural as well as sexual selection, they are of high evolutionary significance. The zebrafish (Danio rerio) ...

  • Du Mercredi 12 Décembre 2018 Au Jeudi 13 Décembre 2018 - Symposium

    Single-Cell Symposium

    The single-cell symposium at Institut Curie will focus on multiple aspects of single-cell technologies applied to (epi)genomics, transcriptomics and proteomics, with 4 sessions dedicated to these aspects. This conference will provide opportunities to get up-to-date with the most recent single-cel...

  • Lundi 17 Décembre 2018 - Séminaire Orateur(s) : Reinhard LAUBENBACHER (Center for Quantitative Medicine - University of Connecticut School of Medicine and Jackson Laboratory for Genomic Medicine)

    Iron metabolism and its role in breast cancer

    Dysregulation of iron metabolism in cancer is well-documented, and it has been suggested that there is an interdependence between excess iron and inreased cancer incidence and progression. This talk will discuss linkages between iron metabolism and breast cancer by way of an intracellular mathema...

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