Liste des séminaires
![]() Pluripotent stem cell models reveal altered genetic and epigenetic pathways in Huntingtons diseaseI will discuss juvenile and infantile forms of human pluripotent stem cell (hPSC) isogenic models for Huntington's disease (HD), the most common poly-glutamine (polyQ) related disorder. HD is caused by CAG (encoding glutamine, Q) expansions within the Huntingtin (HTT) gene. The aberrant polyQ-con... |
![]() B cell memory in barrier tissues - " From the bench to the bedside: cancer immunotherapy with soluble T cell receptors"B cell memory in barrier tissues During infection, the immune system unleashes protective responses to fight against the pathogen while also establishes a memory compartment that will provide protection in case of a subsequent pathogen encounters. The B cell memory compartment is composed of t... |
![]() From perception to action without nerves and muscles: lessons from plantsAs sessile organisms, plants face a constantly changing environment with no means of escape. Thus, despite their lack of nerves and muscles, they have evolved unique mechanisms to perceive and respond to external physical signals. In this seminar, I will illustrate this ability through two emblem... |
![]() When Nuance Matters: The lesser known side of PD1 signalingThe inhibitory immunoreceptor PD1 is a major cancer immunotherapy target. Anti-PD1 blockade antibodies have become the standard of care for cancer patients, but the low response rate and associated immune related side effects necessitate a better understanding of PD1 mechanism. Best known to be e... |
![]() Epigenetics: from human pluripotent stem cell models of neurodegenerative diseases to recent human evolutionIn the first part, I will discuss juvenile and infantile forms of human pluripotent stem cell (hPSC) isogenic models for Huntington's disease (HD), the most common poly-glutamine (polyQ) related disorder. HD is caused by CAG (encoding glutamine, Q) expansions within the Huntingtin (HTT) gene. The... |
![]() Analyse spatiale de données multimodales : quand les omiques rencontrent les images (Biologie des Systèmes du Cancer)Le cours réunira des intervenants de premier plan issus de différents domaines de la biologie des systèmes cancéreux, de la recherche sur le cancer et de la clinique. Les orateurs invités exposeront diverses approches pour l'analyse et l'interprétation des données omiques, d'imagerie et cliniques... |
![]() Breast Cancer Dormancy: A Link to the PastLuca Magnani graduated from his bachelor's and master's degree at the University of Bologna. During an exchange visit to Purdue University, he discovered his interest in early embryogenesis. Dr. Magnani's work took him to Michigan State University, where he continued his research on mouse embryog... |
![]() Epigenetics: from pluripotent stem cells to ancient DNAPluripotent embryonic stem cells (ESCs) are characterized by a unique, globally decondensed, chromatin structure. In the first and main part will describe our endogenously-tagged fluorescent-fusion protein libraries in mouse ESCs, which we used to screen for potential regulators of pluripotency a... |
Endocytic control of cell plasticity in cancerOver the past two decades, there has been a significant shift in our understanding of the role of endocytosis and trafficking of signaling receptors. It has evolved from being viewed simply as a signal extinguisher (resulting in long-term attenuation) to being recognized as a sophisticated mechan... |
![]() 6th International Breast Cancer Course - From Clinics to BiologyThis 6th edition of the international breast cancer course organized by the Institut Curie offers a comprehensive overview of current topics on clinical and biological aspects of breast cancer. This course brings together internationally renowned experts who will present the latest innovations in... |
![]() Developmental Biology: from stem cells to morphogenesis - 15th editionInstitut Curie and Sorbonne Université organize their 15th International Developmental Biology course. The aim of the program is to provide the participants a comprehensive coverage of the paradigms, problems and technologies of modern Developmental Biology paying particular attention to stem ... |
![]() Advanced Course on Immunity and Cancer Immunotherapy 2024The Immunity and Cancer Unit of Institut Curie (INSERM U932) is organizing the 7th edition of the Advanced Course on Immunity and Cancer Immunotherapy. In the context of ongoing cooperation projects with research teams in Chile and Argentina that have resulted in the prior organization of work... |
![]() Advanced Course on Immunity and Cancer Immunotherapy 2024The Immunity and Cancer Unit of Institut Curie (INSERM U932) is organizing the 7th edition of the Advanced Course on Immunity and Cancer Immunotherapy. In the context of ongoing cooperation projects with research teams in Chile and Argentina that have resulted in the prior organization of work... |
![]() Compartment-specific protein dynamics and signalling in living cells revealed by smFRETProteins in cells are not homogeneously distributed, but often localized to specific compartments, which may or may not be enclosed by membranes. Here I will first discuss the dynamic formation of membraneless compartments in the non-equilibrium environment of living cells and how this formati... |