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  • Mercredi 23 Mai 2018 - Séminaire Orateur(s) : Anne-Claude Gavin (EMBL - Group Biochemical networks in health and diseases)

    A network of lipid-transfer proteins at the crossroads between metabolism and signalling

    Lipid metabolism attracts much attention owing to the pleiotropic roles of lipids and their implication in human pathologies, and this interest motivates growing efforts dedicated to cataloguing the lipidome. However, all aspects of lipid function rely on their heterogeneous distribution in livin...

  • Mercredi 23 Mai 2018 - Séminaire Orateur(s) : Petra HAJKOVA (MRC London Institute of Medical Sciences)

    Developmental reprogramming: how to make an epigenetically "naïve" state

    “Epigenetic reprogramming encompasses changes in nuclear architecture and epigenetic modifications that eventually lead to a shift in gene expression profile”

  • Mercredi 23 Mai 2018 - Séminaire institutionnel "Mayent - Rothschild" Orateur(s) : Rytis Prekeris (University of Colorado, Denver, CO, USA)

    The Integration of Polarized Membrane Traffic and Cytoskeleton Dynamics: from epithelial cell polarity to cell migration

    The establishment and maintenance of cell polarity is one of the key functions required successful organ morphogenesis and function. Polarized endocytic membrane transport and cytoskeleton dynamics have emerged as main regulators during cell polarization. In this talk I will overview our recent w...

  • Du Mercredi 23 Mai 2018 Au Jeudi 24 Mai 2018 - Séminaire EU-Life

    EU-LIFE Scientific Meeting 2018

    EU-LIFE is an alliance of independent European research institutes in the life-sciences, striving to create an environment that stimulates excellence in research through sharing best practices and expertise in research organization and management. It is a voice for independent research institutes...

  • Jeudi 24 Mai 2018 - Séminaire Orateur(s) : Anne Villeneuve (Genetics and Developmental Biology, Developmental Biology Department, Stanford University, USA)

    Architecture and dynamics of meiotic chromosome structures and recombination sites

    Research in the Villeneuve lab is aimed at understanding the molecular and cellular mechanisms underlying the faithful inheritance eukaryotic chromosomes. Our primary focus is on elucidating the events required for the orderly segregation of homologous chromosomes during meiosis, the crucial proc...

  • Jeudi 24 Mai 2018 - Séminaire EU-Life Orateur(s) : Laurence Zitvogel (Gustave Roussy - Curie)

    A burgeoning field : the essential role of the gut microbiome in cancer therapeutics

    May 24 , 11.30 am Amphi BURG 

  • Lundi 28 Mai 2018 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Thanos Halazonetis (Department of Molecular Biology, University of Geneva, Switzerland)

    DNA replication stress and cancer

    Genomic instability is one of the most important factors driving cancer progression and resistance to therapy. Oncogenes, by inducing DNA replication stress, are a critical factor underlying genomic instability in cancer, but the mechanisms by which oncogenes cause DNA replication stress have rem...

  • Lundi 28 Mai 2018 - Séminaire Curie TechWatch Orateur(s) : Deborah Moine, David Stucki, Sonia Lameiras (Institut Curie), Marc Deloger (Institut Curie)

    Pacific Biosciences Sequencing technology at Institut Curie

                Agenda:  *   An introduction to the PacBio SMRT Sequencing technology and its applications for Human Biomedical Research (45 min)  by Déborah Moine and David Stucki, PacBio Field Application Scientists   *   PacBio implementation at the NGS platform (20 ...

  • Mercredi 30 Mai 2018 - Séminaire Orateur(s) : Sheila López-Cobo (Autónoma University, Madrid, Spain)

    Ligands for the immune activating receptor NKG2D: different features affecting NK cell response

    Natural Killer (NK) cells play a key role in tumor control, and recognition by the activating receptor NKG2D of its ligands is particularly important for this activity, since although absent on healthy cells, NKG2D ligands (NKG2D-L) are expressed by stressed cells in different pathological situat...

  • Du Lundi 28 Mai 2018 Au Mercredi 30 Mai 2018 - Conférence jointe Orateur(s) :

    Weizmann Institut of Science and Institut Curie Biological Physics Days

    This joint workshop aims at presenting the advancement and novel discoveries made in the field of Biological Physics, spanning all scales from molecules to cells to tissues to organisms, at the Institut Curie (and surrounding Institutions such as the ESPCI and ENS) and at the Weizmann Institute o...

  • Mercredi 30 Mai 2018 - Séminaire Orateur(s) : Angela Vasaturo (INSERM UMRS1138 Integrative Cancer Immunology / Cordeliers Research Center)

    Unraveling the tumor microenvironment architecture by multispectral imaging

    The natural history of cancer involves interactions between the tumor and the immune defense mechanism of the host. The crucial role of the patient's own immune system on clinical outcome is demonstrated by the immunological characterization of the tumor microenvironment. The analysis of type, lo...

  • Jeudi 31 Mai 2018 - Séminaire Cell Biology Series Orateur(s) : Lars JANSEN (Instituto Gulbenkian de Ciência, Oeiras, Portugal)

    Chromatin-based epigenetic inheritance

    The genome is propagated through cell division cycles by the faithful duplication and segregation of chromosomes into two new daughter cells during mitotic divisions. In addition, so-called "epigenetic" chromosome structures that maintain functional chromosomes and that "memorize" the transcripti...

  • Jeudi 31 Mai 2018 - Séminaire institutionnel "Mayent - Rothschild" Orateur(s) : Rytis PREKERIS, PhD

    How to make invadopodia: Coordinating membrane traffic and actin dynamics during cell migration

    *** See biosketch attached. ***  

  • Vendredi 1 Juin 2018 - Séminaire Orateur(s) : Damien ARNOULT (INSERM U542, Hopital Paul Brousse, Universite Paris Sud)

    A cytosolic unfolded protein response controls innate immune signaling

    Multiple cytosolic innate sensors form large oligomers following activation, yet this assembly needs to be tightly regulated to avoid accumulation of misfolded aggregates. We observed that the eIF2α kinase of the highly conserved integrated stress response (ISR) pathway, heme-regulated inhi...

  • Lundi 4 Juin 2018 - Séminaire Immunology series Orateur(s) : Daniel MUCIDA (Lab of Mucosal Immunology, The Rockefeller University, New York NY )

    Immune homeostasis via compartmentalized gut lymph node drainage

    The intestinal immune system has the challenging role of tolerating foreign nutrients and the luminal microbiome, while excluding or eliminating pathogens; failure in these processes leads to a range of intestinal diseases such as food allergies, Celiac Disease, Inflammatory Bowel Diseases and ga...

  • Mardi 5 Juin 2018 - Séminaire Orateur(s) : Cynthia J. Burrows (Department of Chemistry, University of Utah, 315 S. 1400 East, Salt Lake City, UT 84112-0850, USA)

    DNA Damage in G-Quadruplexes Regulates Gene Expression via Base Excision Repair

         Interplay between DNA repair of the oxidatively modified base 8-oxo-7,8-dihydroguanine (OG) and transcriptional activation has been observed in the VEGF, TNF-α, SIRT1, and BCL2 genes.  We synthesized OG into the VEGF potential G-quadruplex sequence (PQS) in the coding strand of a lucif...

  • Mercredi 6 Juin 2018 - Séminaire Orateur(s) : Alessio BAVA (Institut Curie)

    High parameter single-cell proteins and RNAs analysis: from new technologies to cancer immunology

    The goal of this seminar is to give an overview on my past work, as well as to introduce the questions that my group will aim at addressing. I will showcase few single-cell technologies that my colleagues and I have developed at Stanford University, which apply to multiplexed imaging, mass cyt...

  • Mercredi 6 Juin 2018 - Séminaire Orateur(s) : Thierry VOET (Sanger Institute - EBI Single-Cell Genomics Centre, Hinxton, UK & Associate Professor at the University of Leuven (KU Leuven), Belgium)

    Single-cell (multi-omics) sequencing to study cellular heterogeneity in health and disease

    Thierry Voet, co-founder and group leader of the Sanger Institute-EBI Single-Cell Genomics Centre, Hinxton, UK  and Associate Professor of the KU Leuven, Belgium, will be visiting the Institut Curie on Feb 2 and giving a seminar entitled: “Single-cell (multi-omics) sequencing to study cellu...

  • Jeudi 7 Juin 2018 - Séminaire

    Life after PhD…Career Support and Gender Equality

    Gerlind Wallon is the deputy director of the European Molecular Biology Organization (EMBO). A German native, she graduated with a PhD in Biochemistry from Brandeis University, Waltham, Massachusetts, USA, followed by a post-doctoral period at EMBL in Heidelberg. At EMBO she is responsible for...

  • Jeudi 7 Juin 2018 - Séminaire Orateur(s) : Naoya SHIKAZONO (Quantum Beam Science Research Directorate, National Institutes of Quantum and Radiological Science and Technology, Kansai Photon Science Institute, Kizugawa-Shi, Kyoto, Japan)

    Biological effects of ionizing radiation and clustered DNA damage

    After living cells are exposed to ionizing radiation, a variety of chemical modifications of DNA are induced either directly by ionization of DNA or indirectly through interactions with water-derived radicals. The DNA lesions include single strand breaks (SSB), base lesions, sugar damage, and apu...

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