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  • Jeudi 24 Janvier 2019 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Richard D Cummings,

    Integration of Glycomics, Development, and Immunology

    Ludger Johannes has invited  Pr Richard D. Cummings from Beth Israel Deaconess Medical Center Harvard Medical School to come and give a talk on "Integration of Glycomics, Development, and Immunology". He will also participate in the Pastor's course

  • Mardi 29 Janvier 2019 - Séminaire Cell Biology Series Orateur(s) : Julien DUMONT (Institut Jacques Monod - Cell Division and Reproduction )

    Probing the Mechanisms of Chromosome Segregation with C. elegans

    During cell division, accurate chromosome segregation ensures the genetic integrity of cells and organisms, and shields them against aneuploidy, a hallmark of many cancers. By using the nematode Caenorhabditis elegans, we have gained important insights into the machinery and mechanisms that contr...

  • Mercredi 30 Janvier 2019 - Séminaire Orateur(s) : Doron Grossman (The Hebrew University of Jerusalem)

    From Molecules to Helical Ribbons - Shape and Shape Fluctuations

    Self assembly of molecules into supramolecular structures is an important process through which non trivial structures are formed in nano-metric scale. The resulting structure depends on chemical and physical principles that govern the process, and may be sensitive to the exact conditions in whic...

  • Mercredi 30 Janvier 2019 - Séminaire Orateur(s) : Amandine Pluchet (Responsable des services à la recherche de l’Université Paris-Saclay)

    Enhancing the visibility and accessibility of research : Open Access and bibliometrics

    Amandine Pluchet abordera entre autres : comment déposer une publication dans un archive ouverte (HAL, ArXiv….), publier dans une revue Open Access,  l'utilisation des licences Créatives Communs pour diffuser sa production scientifique, les aspects de bibliométrie (usages, critères, indica...

  • Mercredi 30 Janvier 2019 - Séminaire Orateur(s) : Yuyu SONG (Havard University Medical School, Boston, USA)

    Motor neuron disease and microtubule cytoskeleton: highways and scaffolds for signaling

    Microtubules (MTs) are structural components vital for important neuronal functions including neurite outgrowth and maintenance, as well as axonal trafficking and synaptic remodeling. Heterozygous missense mutations in specific tubulin genes, such as TUBA1, TUBB2B, and TUBB3 have been associated ...

  • Mardi 5 Février 2019 - Séminaire Nuclear dynamic series Orateur(s) : Sandra Duharcourt (Institut Jacques Monod)

    Lessons from Paramecium genome gymnastics : A dual histone H3 K9/K27 Polycomb protein ensures transposable element repression

    In animals and plants, the H3K9me3 and H3K27me3 chromatin silencing marks are deposited by different protein machineries and play distinct cellular roles. We show that the Enhancer-of-zeste-like protein Ezl1 from the unicellular eukaryote Paramecium tetraurelia, which exhibits significant sequenc...

  • Mardi 5 Février 2019 - Séminaire Orateur(s) : Cindy Neuzillet (Institut Curie)

    Inter- and intra-tumoral heterogeneity and dynamics of cancer-associated fibroblasts in pancreatic ductal adenocarcinoma and implications for immune therapy

    Cancer-associated fibroblasts (CAF) are orchestrators of the pancreatic ductal adenocarcinoma (PDAC) microenvironment. Stromal heterogeneity may explain differential pathophysiological roles of the stroma (pro- vs. anti-tumoral) in PDAC. We hypothesised that multiple CAF subtypes exist in PDAC th...

  • Vendredi 8 Février 2019 - Séminaire Orateur(s) : Bradley R. Cairns (Huntsman Cancer Institute, Salt Lake City)

    Bradley R. Cairns: Chromatin and Transcription Dynamics in the Germline and Early Embryos

    If you would like to meet the speaker, please contact Deborah.Bourchis@curie.fr

  • Vendredi 8 Février 2019 - Séminaire Orateur(s) : Dmitry Bulavin (Institute for Research on Cancer and Aging, IRCAN Nice)

    Senescence as a conundrum of life and death

    Aging is the major risk factor for many chronic diseases accounting for the bulk of morbidity, mortality, and health costs in the world. There is significant evidence that the accumulation of senescent cells can drive many phenotypes and pathologies associated with aging. How senescence mechanist...

  • Lundi 11 Février 2019 - Séminaire Immunology series Orateur(s) : Gunnar Schotta (Biomedical Center, LMU Munich, Munich, Germany)

    Silencing Mechanisms of endogenous retroviruses

    Epigenetic mechanisms regulate multiple aspects of normal development (stem cell maintenance, differentiation). Misregulation of epigenetic programs can result in aberrant development (cancer, aging). In this context we study the mechanisms of epigenetic gene regulation using a combination of mou...

  • Mardi 12 Février 2019 - Séminaire Orateur(s) : Beat Fierz

    Gene regulation with a “twist”: Exploring the dynamic chromatin landscape

    Abstract: The dynamic organization of the eukaryotic genome into chromatin is integral to genome regulation. Chromatin structure and dynamics, modulated by histone post-translational modifications (PTMs) as well as architectural proteins, dictate DNA access for transcription factors and the gene ...

  • Mercredi 13 Février 2019 - Séminaire Orateur(s) : Andela Saric (University College London, United Kingdom)

    Sensing and creating mechanical forces by protein assembly

    Responding to mechanical cues and producing mechanical forces is central to survival and adaptation of all organisms. To do so, cells dynamically organise a large number of membrane proteins into functional nanoscale structures. Due to their multiscale nature, such processes are challenging to re...

  • Mercredi 13 Février 2019 - Séminaire Orateur(s) : Daniel Jarosz

    Domain 2 Seminar - Daniel Jarosz

    Title & abstract to come.

  • Vendredi 15 Février 2019 - Séminaire Orateur(s) : Antoine H.F.M. Peters (Friedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland)

    Domain 2 seminar - Antoine H.F.M. Peters

    Title & abstract to come.

  • Vendredi 15 Février 2019 - Séminaire Orateur(s) : Antoine Peters (Friedrich Miescher Institute for Biomedical Research (FMI))

    Chromatin based control of germ cell and early embryonic development in mice

    In mammals, fusion of two highly differentiated gametes gives rise to a totipotent zygote capable of developing into a whole organism. The switch in cell fate coincides with translation and degradation of maternally provided transcripts, initiation of global transcription and “epigenetic re...

  • Lundi 18 Février 2019 - Séminaire Orateur(s) : Cécile Alanio (Wherry lab, Institute for Immunology, Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA)

    High Dimensional Profiling of T cells in latent infections and cancer

    To understand potential immune system alterations in newly diagnosed, untreated, pancreatic cancer patients and provide a foundation for immunotherapy, we profiled PBMC from pancreatic ductal adenocarcinoma (PDA) patients and age matched healthy controls using high dimensional CyTOF analysis. We ...

  • Lundi 18 Février 2019 - Séminaire Orateur(s) : Ulrich Kalinke (TWINCORE, Zentrum für Experimentelle und Klinische Infektionsforschung GmbH, Hanover, Germany)

    Virus defense at the brain border

    5 recent publications: Chhatbar C, Detje CN, Grabski E, Borst K, Spanier J, Ghita L, Elliott DA, Jordão MJC, Mueller N, Sutton J, Prajeeth CK, Gudi V, Klein MA, Prinz M, Bradke F, Stangel M, Kalinke U. Type I Interferon Receptor Signaling of Neurons and Astrocytes Regulates Microglia Activatio...

  • Mercredi 20 Février 2019 - Séminaire Orsay series Orateur(s) : Lukas Trantirek (Central European Institute of Technology, Masaryk University & Institute of Biophysics, Czech Academy of Sciences, Brno, Czech Republic )

    In-cell NMR spectroscopy: Monitoring of structure, stability, and interactions of DNA at high resolution in nuclei of living human cells.

    The structure, dynamics and interactions of nucleic acids, DNA in particular, sensitively respond to a broad range of environmental factors many of them being natively present in intracellular space.  In-cell NMR spectroscopy is a tailored adaptation of conventional high-resolution nuclear magnet...

  • Jeudi 21 Février 2019 - Séminaire Orateur(s) : Masaru Ishii (Department of Immunology and Cell Biology, Graduate School of Medicine, Osaka University, Osaka, Japan)

    Dynamics of immune cell migration and interaction visualized by intravital microscopy

    During the last decade, intravital optical microscopy has launched a new trend in the field of biology. By using this advanced imaging technique we have established a new system for visualizing in situ behavior of a diversity of living cells within intact tissues and organs. Among them, we succee...

  • Lundi 4 Mars 2019 - Séminaire Orateur(s) : Sara Richter (Dept Molecular Medicine University of Padua, Italy)

    Presence, function and targeting of G-quadruplexes in the human immunodeficiency virus-1 (HIV-1)

    Presence, function and targeting of G-quadruplexes in the human immunodeficiency virus-1 (HIV-1)

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