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  • Mardi 20 Février 2018 - Séminaire CDC Orateur(s) : Xavier MORIN (Institut de Biologie Ecole Normale Supérieure (IBENS))

    Asymmetric cell division, Notch signaling and neurogenesis in the vertebrate embryonic spinal cord

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  • Mercredi 21 Février 2018 - Séminaire Orsay series Orateur(s) : Oscar Fernandez-Capetillo (Genomic Instability Group, Spanish National Cancer Research Centre, Spain; Division of Genome Biology, Karolinska Institute, Sweden)

    Coordinating DNA Replication Termination with Mitotic Entry

             G2 is defined as the “growth” phase that follows DNA replication and precedes mitosis. However, recent works have shown examples of uncompleted replication that persists all the way to mitosis, where it leads to chromosomal breakage and genome instability. How or if mechanism...

  • Mardi 27 Février 2018 - Séminaire CDC Orateur(s) : René-Marc MEGE (Institut Jacques Monod, Université Paris Diderot)

    Biogenesis and mechanobiology of adherens junctions

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  • Vendredi 2 Mars 2018 - Séminaire Orateur(s) : Yongmin ZHANG (Université Pierre et Marie Curie-Paris 6)

    Design, synthesis and biological evaluation of carbohydrate derivatives as potential antitumor and antiviral agents

    Glycosphingolipids (GSLs) are components of all animal cell membranes and are involved in many cellular functions including proliferation, adhesion, motility, and differentiation. Ganglioside GM3 (NeuAcα3Galβ4Glcβ1Cer), the first and simplest member in the metabolic series of a GS...

  • Vendredi 2 Mars 2018 - Séminaire Orateur(s) : Dr Diana Passaro, PhD (Haematopoietic Stem Cell Laboratory,The Francis Crick Institute)

    Acute myeloid leukemia associated alteration of the bone marrow microenvironment

    Recent studies have suggested that the initiation and progression of leukemias also depend on their ability to interact with the non-malignant microenvironment, which produces fundamental factors for leukemic cell survival and at the same time adapts to their own needs to promote the progression....

  • Vendredi 2 Mars 2018 - Séminaire Orateur(s) : Ranjan J. Perera Ph.D. (Sanford Burnham Medical Discovery Institute & The Johns Hopkins University)

    The long noncoding RNA SPRIGHTLY (SPRY4-IT1): a new player in different diseases

    Long noncoding RNAs (lncRNAs) were once dismissed as non-functional genomic noise. There is now compelling evidence that lncRNAs play critical roles in human pathophysiology. However, the molecular mechanisms by which the vast majority of lncRNAs regulate their target genes, and proteins remain u...

  • Lundi 5 Mars 2018 - Séminaire Curie TechWatch Orateur(s) : Simon Andrews (Babraham Institute), Felix Krueger (Babraham Institute)

    Developing explorative bioinformatics tools for biologists

    Simon Andrews and Felix Krueger from the Bioinformatics Group at the Babraham Institute will speak about the development of explorative bioinformatics tools. The group developed among others a large array of publicly available tools for analysis of genomics data as Bismark, FastQC, or SNPsplit. M...

  • Mardi 6 Mars 2018 - Séminaire CDC Orateur(s) : Stéphane VASSILOPOULOS (Myologie Centre de Recherche/ Institut de Myologie, G.H. Pitié-Salpêtrière, Paris)

    CLATHRIN PLAQUES FORM MECHANOTRANSDUCING PLATFORMS

    Large flat clathrin lattices, clathrin plaques, are stable features of the plasma membrane observed in several cell types. They have been associated with sites of strong adhesion suggesting that they could also play a role in force transduction. Here, I will present our work on a compartment comp...

  • Vendredi 9 Mars 2018 - Séminaire Orateur(s) : Hakon Leffler (Hakon Leffler Lund University Sect MIG, Inst. Laboratory Medicine Dept. Clinical Immunology, Lund University Hopsital Sölvegatan 23 22362 Lund Sweden)

    Galectins: intra and extracellular functions diagnostic and therapeutic targets in many diseases

    Galectins were discovered in a quest to find proteins binding cell surface carbohydrates and taking part in cell adhesion, and this is indeed one of the roles of galectins. However, they have many other roles. Galectins bind β-galactose containing glycans typically found at the cell surface ...

  • Vendredi 9 Mars 2018 - Séminaire Orateur(s) : Jorge FERREIRA (i3S ¬ - Instituto de Investigação e Inovação em Saúde and Faculdade de Medicina - Universidade do Porto, Portugal)

    Forces and shape changes in cell division

    Accurate chromosome segregation during mitosis requires the efficient assembly of a microtubule-based structure known as the mitotic spindle. To achieve this, most cells rely on centrosomes, which must separate to establish a bipolar geometry and ultimately establish division plane orientation. P...

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