Interaction of the mucosal immune system with the microbiota

The microbiota is emerging as an important environmental factor influencing several functions of our body. Many disorders have been associated to a disequilibrium of the microbiota that is called dysbiosis., these include not only gut disorders as inflammatory bowel disease and colorectal cancer,...

Coupling and Uncoupling Transcription with Translation

We show that transcription and translation are physically coupled in E.coli by the NusG protein. The NTD of NusG binds RNAP, whereas its CTD binds ribosomal protein S10. We present a cryo-EM structure showing NusG CTD bound to S10 in an intact 70S ribosome. We find that NusG is required for coupl...

A liquid crystalline interface between chromosomes controls meiotic recombination

Dr. Dernburg's lab is interested in meiosis, the special division process by which the genetic information on chromosomes is transmitted from parent to progeny through sexual reproduction. Errors in this process lead to aneuploidy and are a major cause of human birth defects such as Down syndrome...

Assessing the engines of affinity maturation to vaccines: germinal centers and Tfh cells

T cell help to B cells was one of the earliest discovered functions of T cells, 49 years ago, resulting in the coining of the term ‘helper cell'. Follicular helper T cells (Tfh) are the specialized CD4 T cells for B cell help. Generation of long term humoral immunity is a complex process pr...

Precision Medicine and DNA-Targeted Agents

Tuft cells : intestinal epithelial sentinels linking luminal danger to immune responses

- Gerbe F., Sidot E., Smyth D. J., Ohmoto M., Matsumoto I., Dardalhon V., Cesses P., Garnier L., Pouzolles M., Brulin B., Bruschi M., Harcus Y., Zimmermann V. S., Taylor N., Maizels R. M. and Jay P. : Intestinal epithelial tuft cells initiate type 2 mucosal responses to helminth parasites. Nature...

Positioning the nucleus for cell function

Connecting the nucleus to the cytoskeleton is relevant for multiple cellular processes and disruption of these connections result in multiple pathologies. Nuclear positioning within cell cytoplasm requires de connection between nucleus and the cytoskeleton. We are interesting to understand the pr...

Ultraviolet A-induced oxidation in the cornea: short and long-term effects

Human eye is directly exposed to solar ultraviolet (UV) radiations but the retina is protected from those rays. Indeed, the cornea and the lens filter UV rays to protect the retina against their toxicity. The UVA component represents 95% of solar UV radiation and has photo-oxidant properties. How...

"DNA repair, Repair syndromes and Radiation biology" - Symposium in memory of Dr. Ethel Moustacchi

The symposium DNA repair, Repair syndromes and Radiation Biology is a tribute to the memory of Ethel Moustacchi. Her name is undoubtedly linked to the Institut Curie that is why this symposium will take place in our premises. The symposium will cover the research themes to which Ethel Moustac...

Making two equal one: Human X-chromosome inactivation

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