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  • Thursday, 30th, May 2024 - Séminaire Keynote BDD Speaker(s) : Yanlan Mao (University College London, UK)

    Coping with mechanical stress: tissue dynamics during development, homeostasis and repair.

      Abstract: During growth and development, tissue dynamics, such as tissue folding, cell intercalations and oriented cell divisions, are critical for shaping tissues and organs. However, less is known about how tissues regulate their dynamics during tissue homeostasis and repair, to maint...

  • Friday, 31st, May 2024 - Séminaire Speaker(s) : Wei Yang (National Institute of Health - NIH)

    Cutting and Pasting DNA to Create our Adaptive Immune System

    V(D)J recombination is essential for generating the adaptive immune response and unlimited number of different antibodies and antigen receptors. Encoded by multiple V, D and J gene segments, antigen receptors are assembled by programmed double-stranded DNA cleavage and imprecise re-joining. RAG1/...

  • Monday, 3rd, June 2024 - Séminaire Speaker(s) : Patrice Gouet (Institut de Biologie et Chimie des Protéines)

    Le nouveau serveur web FoldScript, exploitant le meilleur des modèles AlphaFold : cas de test des complexes protéiques IN:IN et RT:IN du HIV-1

    Les programmes de modélisation 3D utilisant l'intelligence artificielle (IA) ont révolutionné la biologie structurale, permettant souvent de prédire les structures des protéines avec des niveaux de confiance sans précédent. Cependant, ces structures restent des modèles, et il est toujours intéres...

  • Wednesday, 5th, June 2024 - Séminaire Speaker(s) : Robert Arkowitz

    Probing morphogenesis and drug susceptibility at multiple scales, in a human fungal pathogen

    We have been focusing on the yeast to hyphal transition, as well as subsequent filamentous growth, both that of the main filament apex and filament branching, in the human fungal pathogen, Candida albicans. Filament branching results in an increase in the number of growth sites and may play a ...

  • Wednesday, 5th, June 2024 - Séminaire Speaker(s) : Paule Dagenais

    Mechanical positional information guides the self-organized development of a polygonal network of creases in the skin of mammalian noses

    The glabrous skin of the rhinarium (naked nose) of many mammalian species exhibit a polygonal pattern of grooves that retain physiological fluid, thereby keeping their nose wet and, among others, facilitating the collection of chemosensory molecules. In this talk, I will discuss how rhinarial pol...

  • Thursday, 6th, June 2024 - Séminaire institutionnel "Mayent - Rothschild" Speaker(s) : Claude DESPLAN (NYU Department of Biology)

    THE GENERATION OF NEURONAL DIVERSITY AND ITS EVOLUTION

    In the Drosophila optic lobes, ~200 types of neurons organized as 800 columns process the inputs from 800 unit-eyes. We study how this variety of neurons is generated during development and how connectivity among these neurons is regulated             The ~800 Neural stem cells in the medulla ...

  • Friday, 7th, June 2024 - Séminaire Speaker(s) : Aurélien Roux

    Active nematic order in morphogenesis of the Hydra

    Hydra is named after the mythological animal for its regenerative capabilities, but contrary to its mythological counterpart, it only regenerates one head when cut. Here we show that soft compression of head regenerating tissues induces the regeneration of viable, two headed animals. Topological ...

  • Monday, 10th, June 2024 - Séminaire Speaker(s) : Dolores Di Vizio (Cedars-Sinai Medical Center)

    Functional and molecular characterization of cancer-derived extracellular vesicles

    Cancer-derived extracellular vesicles have been demonstrated to play a crucial role in cancer biology. Our team is particularly interested in cancer EV heterogeneity and we have been studying a particular population of extracellular vesicles, known as large oncosomes. These EVs are released by ag...

  • Tuesday, 11th, June 2024 - Séminaire Cell Biology Series Speaker(s) : Stefan RAUNSER (Max Planck Institute of Molecular Physiology )

    Structures in situ des sarcomères musculaires et des protéines sarcomères

    Les sarcomères sont des dispositifs musculaires générateurs de force et porteurs de charge. Une image moléculaire précise de la façon dont les sarcomères sont construits permet de comprendre leur rôle dans la santé et les maladies. Nous avons déterminé l'architecture moléculaire des sarcomères sq...

  • Friday, 14th, June 2024 - Séminaire Speaker(s) : Anne Bowcock

    Defining the roles of genetic drivers of uveal melanoma with cell-based and Drosophila models

    Uveal melanoma is the most common eye cancer in adults with a set of highly characteristic genetic alterations. We identified mutations in the BAP1 (BRCA1 Associated Protein 1) gene in uveal melanomas with high likelihood of metastasis and recurrent mutations in the splicing factor SF3B1 with les...

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