Liste des séminaires
 Mardi 13 Novembre 2018 - Séminaire Cell Biology Series Orateur(s) : Lukas HUBER, PhD LAMTOR and BORC regulate the position and size of late endosomes/lysosomes***** |
A revolutionary platform for vector design, custom cloning and virus packagingVectorBuilder is a revolutionary online platform aimed at providing researchers with one-stop solutions to all their vector design, custom cloning and virus packaging needs. Besides cloning and virus packaging, VectorBuilder offers many other molecular biology services such as BAC modification (r... |
Nuclear envelope mechanics and genome tethering in gene regulation: constrained diffusion and the lamin springThe nuclear envelope (NE) is a complex double membrane system supported by the intermediate filament lamin polymer and many NE transmembrane proteins (NETs) that connect it to both cytoplasmic filaments from the outer nuclear membrane and chromatin from the inner nuclear membrane. These latter co... |
Nuclear envelope mechanics and genome tethering in gene regulation: constrained diffusion and the lamin springThe nuclear envelope (NE) is a complex double membrane system supported by the intermediate filament lamin polymer and many NE transmembrane proteins (NETs) that connect it to both cytoplasmic filaments from the outer nuclear membrane and chromatin from the inner nuclear membrane. These latter co... |
A revolutionary platform for vector design, custom cloning and virus packagingVectorBuilder is a revolutionary online platform aimed at providing researchers with one-stop solutions to all their vector design, custom cloning and virus packaging needs. Besides cloning and virus packaging, VectorBuilder offers many other molecular biology services such as BAC modification (r... |
Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymesTau is an intrinsically disordered protein, which diffuses on microtubules. In neurodegenerative diseases collectively termed tauopathies, tau malfunction and its detachment from axonal microtubules is correlated with microtubule degradation. It is known that tau can protect microtubules from mic... |
Multiplexed mass spectrometric lipid metabolic tracing with single cell sensitivityLipid metabolic tracing is a key technology to understand lipid metabolism in health and disease. We have previously demonstrated tracing with picomole sensitivity and lipid class resolution using alkyne-labeled lipids and detection by fluorogenic click reaction combined with TLC separation. To t... |
Pediatric medulloblastoma: Molecular Pathways and Pre-Clinical TrialsMedulloblastoma (MB) is the most common malignant brain tumor that develops in the cerebellum. MB occurs mostly in children between the ages of 3-7 years. Human MBs are classified into four major subgroups: Wingless (WNT), Sonic Hedgehog (SHH), Group 3 (G3) and G4, each of which has distinct mole... |
 Mardi 20 Novembre 2018 - Séminaire Cell Biology Series Orateur(s) : Ruth KROSCHEWSKI (ETH Zurich - Institute of Biochemistry, Zurich) Plasmid DNA transfection, revealing tolerant yet separatist mammalian cellsThe genome of mammalian cells is challenged by extra-chromosomal DNA introduced by viruses, bacteria, or transfection of plasmid DNA. However, how cells handle these DNA molecules is largely unknown. We analyzed predominantly Hela cells stably expressing fluorescently tagged LacI protein and t... |
From transient compartmentalization to cell population dynamicsIn the fifties, Oparin imagined liquidlike compartments called coacervates, which could have played a central role in the origin of life [1]. Although the experimental verification of this idea remained scarce for many years, the idea resurfaced recently in various systems of biological... |