Role of stem cell niche and asymmetric cell divisions in aging

___

Molecular Mechanism of Chromosome Maintenance by Homologous Recombination: Seeing and Understanding BRCA2 and RAD51 Functions

Molecular Mechanism of Chromosome Maintenance by Homologous Recombination: Seeing and Understanding BRCA2 and RAD51 Functions

Microtubule Regulating Pathways in Synaptic Injury and Bortezomib-Induced Axonal Degeneration

Emerging studies from several groups have indicated that dynamic microtubules, in addition to modified microtubules, play key roles in neuronal function. In addition, synaptic biphasic fluctuations of microtubule instability/stability and tubulin post-translational modifications (PTMs) have recen...

Mini-symposium: Qualitative modelling

9:30 – 10:10 AM: Franck Delaplace (IBISC Lab., Evry Val d'Essonne University): Abduction based Drug/Disease targets Inference 10:10-10:50 AM: Elisabeth Remy (Institut de Mathématiques de Marseille (I2M)): The versatility of the logical modeling : Some illustrations 10:50 – 11:10...

The dynamic coupling between metabolic signaling and genome surveillance mechanisms

Faithful and complete duplication of genome relies on the precise regulation of DNA replication and protection of newly synthesized DNA. Globally, DNA replication is determined by the frequency of replication initiation and the speed of individual forks. While the series of events required for in...

Understanding how DNA replication stress impacts on chromosome segregation in mitosis

___

Unbiased Discovery of DNA binding proteins: an illustration with DNA methylation

Control of replication fork integrity and replication competence by the nuclear architecture in fission yeast

___

Epigenetic programming of macrophage differentiation and glucocorticoid responses

The molecular basis of cellular memory is a current knowledge frontier. In the immune system, cellular memory likely extends beyond cell fate determination mechanisms since immunity can tailor its responses to a potentially hostile environment that is a priori variable if not unpredictable. One p...

Decoding tumor genomes through the hierarchical pathway architecture of the cancer cell

Although cancer is governed by complex molecular systems, the composition and modular organization of these systems remains poorly understood. I will describe efforts by the Cancer Cell Map Initiative (CCMI) to generate large protein interaction maps of tumor cells, which we are integrating with ...