Séminaires Marie Curie

  • Mardi 18 Septembre 2018 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Stephen J. Simpson (Charles Perkins Centre, The University of Sydney)

    Models and model systems: the nutritional geometry of health and ageing

    The question of what represents a balanced diet and how this maintains health and longevity remains unanswered. The talk will set out an integrative framework, Nutritional Geometry, for describing the multidimensional nature of nutritional requirements, the relative values of foods in relation to...

  • Lundi 28 Mai 2018 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Thanos Halazonetis (Department of Molecular Biology, University of Geneva, Switzerland)

    DNA replication stress and cancer

    Genomic instability is one of the most important factors driving cancer progression and resistance to therapy. Oncogenes, by inducing DNA replication stress, are a critical factor underlying genomic instability in cancer, but the mechanisms by which oncogenes cause DNA replication stress have rem...

  • Mercredi 7 Février 2018 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Phillip Zamore (RNA Therapeutics Institute, University of Massachusetts Medical School, and  Howard Hughes Medical Institute)

    What flies can and can’t teach us about piRNAs

    In animals, PIWI-interacting RNAs (piRNAs) serve as guides for the PIWI clade of Argonaute proteins, an evolutionary conserved family of RNA-binding proteins at the heart of eukaryotic gene silencing pathways. Flies teach us that piRNAs protect the germline from transposons and repetitive sequenc...

  • Jeudi 21 Décembre 2017 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Brent Stockwell (Departments of Biological Sciences and Chemistry, Columbia University)

    Ferroptosis: a regulated cell death nexus linking metabolism, redox biology and disease

    Abstract: Dr. Stockwell will describe the discovery of ferroptosis, a form of regulated cell death characterized by the iron-dependent accumulation of lethal lipid hydroperoxides.  Current data suggest that ferroptosis is an ancient vulnerability caused by the evolution of cells with polyunsatura...

  • Vendredi 24 Novembre 2017 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Robert A. Martienssen (Cold Spring Harbor Laboratory, New York - USA)

    Small interfering RNA in replication, recombination and repair

    Rob Martienssen is investigating the role of heterochromatin reprogramming and RNA interference in plant germ cells. These mechanisms reveal and regulate transposable elements, but they also play important roles in meiosis and reproductive fate.

  • Lundi 9 Octobre 2017 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Jürgen Knoblich (Institute of Molecular Biotechnology (IMBA), Vienna, Austria)

    Neural stem cells and brain development: From Drosophila to humans

    The human brain is the most fascinating and most complex organ of all. Despite this enormous complexity, the billions of neurons in our brain arise from a limited number of progenitors following a specific set of lineage decisions. We combine Drosophila genetics with 3D organoid cultures derived ...

  • Mercredi 27 Septembre 2017 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Hans Clevers (Hubrecht Institute, Utrecht, the Netherlands)

    Stem cell-grown organoids as models for human disease

    The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. We originally defined Lgr5 as a Wnt target gene, transcribed in colon cancer cells. Two knock-in alleles revealed exclusive expression of Lgr5 in cycling, columnar cells at the crypt base. Using lineage tracing e...

  • Jeudi 22 Juin 2017 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Carlos Caldas (Cancer Research UK Cambridge Institute, Cambridge, UK)

    Breast cancers are communities of clones and communities of cells

    Professor Caldas holds the Chair of Cancer Medicine at the University of Cambridge since 2002. He heads the Breast Cancer Functional Genomics Laboratory at the Cancer Research UK Cambridge Research Institute. He is an Honorary Consultant Medical Oncologist at Addenbrooke's Hospital, and Director ...

  • Du Lundi 15 Mai 2017 Au Mardi 16 Mai 2017 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Douglas Green (St. Jude Children's Research Hospital, Memphis, USA)

    To the edge of necroptosis and back

    Publications: Gong, Y., Guy, C. Olauson, H., Becker, J.U., Yang, M., Fitzgerald, P., Linkermann, A., and Green, D.R.  ESCRT-III acts downstream of MLKL to regulate necroptotic cell death and its consequences.  Cell, in press. Quarato, G., Guy, C.S., Grace, C.R., Llambi, F., Nourse, A., Rodr...

  • Mardi 25 Avril 2017 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Clare M. Waterman (Laboratory of Cell and Tissue Morphodynamics, NIH (Bethesda, USA) )

    Integration of actin dynamics and adhesion in cell migration

    Clare Waterman graduated from the Mount Holyoke college with a B.A. in biochemistry in 1989, received an M.S. in exercise science in 1991 from the University of Massachusetts, and received her Ph.D. in cell biology from the University of Pennsylvania in 1995. Prior to joining the NHLBI, she spent...

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