Marie Curie Seminars

  • Monday, 21st, October 2019 - Séminaire institutionnel "Marie Curie Seminar" Speaker(s) : Alex Schier (Harvard University/Biozentrum Basel)

    Cellular Biographies: Reconstructing Developmental Trajectories and Lineages

    Complex gene expression programs determine the biographies of cells: how a cell divides, becomes specialized and differentiates. I will describe our recent efforts to use single-cell RNA sequencing and CRISPR-Cas9 genome editing to generate new tools to reconstruct differentiation trajectories an...

  • Wednesday, 19th, June 2019 - Séminaire institutionnel "Marie Curie Seminar" Speaker(s) : Jorge Reis-Filho (Memorial Sloan Kettering Cancer Center - USA)

    Molecular classification of breast cancer

    Our hypothesis is that the analysis of phenotypically homogeneous subsets of breast cancers will lead to the identification of novel drivers of the disease and pathognomonic mutations. Our goals are to develop a predictive classification system for these rare types of breast cancer and to define ...

  • Monday, 15th, April 2019 - Séminaire institutionnel "Marie Curie Seminar" Speaker(s) : Adrian Krainer (Cold Spring Harbor Laboratory, Long Island, NY, USA)

    Targeted Antisense Therapeutics for Modulation of Splicing or NMD

        Pr. Adrian KRAINER has made huge contributions to our understanding of splicing factors and their role in regulating alternative splicing. In a culmination of this success, he has identified ways to control alternative splicing patterns ...

  • Wednesday, 13th, March 2019 - Séminaire institutionnel "Marie Curie Seminar" Speaker(s) : John Marko (Department of Molecular Biosciences, Northwestern University, Evanston, USA)

    Mechanics, topology and geometry of mammalian chromosomes and nuclei and their modulation by histone epigenetic marks

    Our lab uses biophysical methods, with particular emphasis on micromanipulation of single DNA molecules and single chromosomes, to study the internal structure of chromosomes in vivo, and to study chromosome-organizing proteins and DNA topoisomerases in vitro. We also develop mathematical models ...

  • Friday, 15th, February 2019 - Séminaire institutionnel "Marie Curie Seminar" Speaker(s) : Eric Miska (Gurdon Institute, Univeristy of Cambridge, Cambridge, UK)

    An ancient machinery drives piRNA transcription in C. elegans

    Piwi-interacting RNAs (piRNAs) engage Piwi proteins to suppress transposons and nonself nucleic acids and maintain genome integrity and are essential for fertility in a variety of organisms. In Caenorhabditis elegans, most piRNA precursors are transcribed from two genomic clusters that contain th...

  • Thursday, 24th, January 2019 - Séminaire institutionnel "Marie Curie Seminar" Speaker(s) : Richard D Cummings,

    Integration of Glycomics, Development, and Immunology

    Ludger Johannes has invited  Pr Richard D. Cummings from Beth Israel Deaconess Medical Center Harvard Medical School to come and give a talk on "Integration of Glycomics, Development, and Immunology". He will also participate in the Pastor's course

  • Friday, 18th, January 2019 - Séminaire institutionnel "Marie Curie Seminar" Speaker(s) : George Demetri (Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Boston USA)

    Precise and imprecise therapeutic targeting of sarcomas across the age spectrum

    The biological and clinical diversity of sarcomas represents both a scientific opportunity and a medical challenge.  Although cytotoxic chemotherapy can be curative for an important subset of patients, advances in technology have allowed us to identify mechanisms of oncogenic drivers and therapeu...

  • Friday, 18th, January 2019 - Séminaire institutionnel "Marie Curie Seminar" Speaker(s) : Véronique Gouverneur (University of Oxford, UK )

    Late stage (radio)fluorination. Lessons to be learned from the fluorinase enzyme

    The impact of fluorine chemistry in the life sciences is enormous.  As many as 30−40% of agrochemicals and 20% of pharmaceuticals on the market are estimated to contain fluorine. 19F- and 18F-labelled compounds are also finding increasing applications in imaging such as Magnetic Resonance I...

  • Monday, 17th, December 2018 - Séminaire institutionnel "Marie Curie Seminar" Speaker(s) : David GILBERT (Florida State University)

    Regulation of Replication Timing and Chromosome Architecture

    The temporal order of DNA replication (replication timing, RT) is highly coupled with genome architecture, but cis-elements regulating spatio-temporal control of replication have remained elusive. We performed an extensive series of CRISPR mediated deletions and inversions and high-resolution cap...

  • Monday, 10th, December 2018 - Séminaire institutionnel "Marie Curie Seminar" Speaker(s) : Christiane Nüsslein-Volhard

    Marie Curie Seminar: Christiane Nüsslein-Volhard - How fish colour their skin: A paradigm for development and evolution of adult patterns

    Colour patterns are prominent features of most animals; they are highly variable and evolve rapidly leading to large diversities between species even within a single genus. As targets for natural as well as sexual selection, they are of high evolutionary significance. The zebrafish (Danio rerio) ...

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