Séminaire

Mardi 8 Octobre 2024

11h

Centre de recherche - Paris - Amphithéâtre Hélène Martel-Massignac (BDD)

Séminaire institutionnel "Mayent - Rothschild"

Epigenetics: from pluripotent stem cells to ancient DNA

Pluripotent embryonic stem cells (ESCs) are characterized by a unique, globally decondensed, chromatin structure. In the first and main part will describe our endogenously-tagged fluorescent-fusion protein libraries in mouse ESCs, which we used to screen for potential regulators of pluripotency and early ESC differentiation. I will discuss two prominent hits which we identified: a nuclear protein, SET, involved in regulation of pluripotency and early development, and a cytoplasmic protein, CAPRIN1, involved in degrading developmental RNA transcripts during early ESC differentiation.

In the second part, I will more briefly discuss our recent work on paleo-epigenetics, where we are reconstructing DNA methylation in ancient DNA. This technique allows us to identify differentially methylated genes between modern and archaic humans, and more recently, between pre- and post-Neolithic societies.

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Orateur(s)

Eran Meshorer
Prof.

Department of Genetics, The Institute of Life Science & The Edmond and Lily Safra Center for Brain Sciences (ELSC), The Hebrew University of Jerusalem

Invité(e)(s) par

Geneviève Almouzni

Institut Curie

Contact

Geneviève Almouzni

Institut Curie

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En bref

Prof. Eran Meshorer is the Arthur Gutterman Family Chair for Stem Cell research. Eran completed his PhD at the Hebrew University and performed his post-doctoral studies at the National Cancer Institute, NIH. In 2007, he returned to the Hebrew University as an Alon Fellow and is currently heading the ‘Epigenetics, Stem cells & Neurons’ laboratory in the Department of Genetics and the Edmond and Lily Safra Center for Brain Sciences (ELSC). The Meshorer lab focuses on single cell and genome-wide approaches to understand chromatin plasticity and epigenetic regulation in embryonic and neuronal stem cells, during reprogramming, and in pluripotent models of neurodegenerative diseases, as well as epigenetics of archaic genomes (“paleo-epigenetics”, a field which he co-pioneered). Eran received several awards including the Hestrin Prize from the Israel Society of Biochemistry and Molecular Biology and a Gold Medal from Charles University, Prague. Eran headed the EU funded training network ‘EpiSyStem’, and is currently coordinating the Pathfinder project ‘RT-SuperES’.