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  • Lundi 22 Janvier 2018 - Séminaire CDC Orateur(s) : Roberto WEIGERT (CCR-NCI, National Institutes of Health, Bethesda, USA)

    Molecular mechanisms of membrane remodeling in live animals by intravital subcellular microscopy (iSMIC)

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  • Mercredi 24 Janvier 2018 - Séminaire institutionnel "Mayent - Rothschild" Orateur(s) : Madalena Tarsounas (Genome Stability and Tumourigenesis Group, The CR-UK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, U.K.)

    Chlorambucil counteracts drug resistance in BRCA1/2-deficient cells and tumors

    Tumours lacking BRCA1 or BRCA2 function with compromised homologous recombination (HR) repair accumulate genomic rearrangements conducive for tumorigenesis onset and progression. Remarkably, these defects can be exploited in the clinic to target specifically cancer cells, with PARP inhibitors as ...

  • Vendredi 26 Janvier 2018 - Séminaire Orateur(s) : Yanlan Mao (MRC - Laboratory for Molecular Cell Biology, University College London)

    Tissue dynamics in development and repair

    Actomyosin contractility is a key regulator of tissue dynamics. During development, tissue dynamics, such as cell intercalations and oriented cell divisions, are critical for shaping tissues and organs. However, less is known about how tissues regulate their dynamics during tissue homeostasis and...

  • Vendredi 2 Février 2018 - Séminaire Orateur(s) : Thanos Halazonetis ( Department of Molecular Biology, University of Geneva, Switzerland)

    DNA replication stress and cancer

    DNA replication stress is prevalent in human cancer. I will describe our latest efforts to understand how oncogenes induce DNA replication stress in cancer and how the presence of DNA replication stress in cancers could lead to therapeutic opportunities.

  • Vendredi 2 Février 2018 - Séminaire Orateur(s) : Thierry VOET (Sanger Institute - EBI Single-Cell Genomics Centre, Hinxton, UK & Associate Professor at the University of Leuven (KU Leuven), Belgium)

    Single-cell (multi-omics) sequencing to study cellular heterogeneity in health and disease

        Thierry Voet, co-founder and group leader of the Sanger Institute-EBI Single-Cell Genomics Centre, Hinxton, UK  and Associate Professor of the KU Leuven, Belgium, will be visiting the Institut Curie on Feb 2 and giving a seminar entitled: “Single-cell (multi-omics) sequencing to study c...

  • Mardi 6 Février 2018 - Séminaire CDC Orateur(s) : Marie-Hélène VERLHAC

    Active fluctuations modulate gene expression in mouse oocytes

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  • Mardi 6 Février 2018 - Séminaire Nuclear dynamic series Orateur(s) : Justin CROCKER (EMBL, Heidelberg (Germany))

    Decoding evolution and development: from enhancer structure to function

    The goal of the Crocker group is to reach a level of understanding that will allow the programming and control of developmental fates, extending existing single-cell synthetic biology techniques to whole organism developmental systems. Development is controlled, to a large degree, by regions of g...

  • Vendredi 16 Février 2018 - Séminaire Orateur(s) : Mark Dawson (Peter MacCallum Cancer Centre Victorian Comprehensive Cancer Centre building)

    The cancer epigenome: Concepts, challenges, and therapeutic opportunities

    Cancer biology is profoundly influenced by changes in the epigenome. Because the dynamic plasticity of the epigenome lends itself well to therapeutic manipulation, the past few years have witnessed an unprecedented investment in the development,characterization, and translation of targeted epigen...

  • Vendredi 16 Février 2018 - Séminaire Orateur(s) : Sergio Quezada (UCL Cancer Institute, London)

    Regulatory T cells, Polymorphisms and Response to Checkpoint blockade: From mechanisms to potential biomarkers

    In mice, anti-CTLA-4 monoclonal antibodies (mAbs) require Fc-gamma receptor (FcγR)-mediated depletion of intra-tumoral regulatory T (Treg) cells to promote tumor rejection. However, the relevance of this mechanism in the human setting remains controversial.  Using a mouse model expressing h...

  • Mercredi 21 Février 2018 - Séminaire Orsay series Orateur(s) : Oscar Fernandez-Capetillo (Genomic Instability Group, Spanish National Cancer Research Centre, Spain; Division of Genome Biology, Karolinska Institute, Sweden)

    Coordinating DNA Replication Termination with Mitotic Entry

             G2 is defined as the “growth” phase that follows DNA replication and precedes mitosis. However, recent works have shown examples of uncompleted replication that persists all the way to mitosis, where it leads to chromosomal breakage and genome instability. How or if mechanism...

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