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  • Thursday, 1st, September 2016 - Séminaire institutionnel Mayent - Rothschild Speaker(s) : Hermann Rohrer

    The roles of neuroblastoma driver genes (ALK, MYCN, LIN28B) in embryonic sympathetic neuroblasts

    Neuroblastoma (NB) is a childhood tumor of the autonomic nervous system that is restricted to sympathetic ganglia and adrenal medulla. To understand the transition from normal to aberrant neurogenesis leading to tumor formation, we have addressed the endogenous function of genes identified as NB ...

  • Friday, 2nd, September 2016 - Séminaire institutionnel Mayent - Rothschild Speaker(s) : Kunxin Luo (Department of Molecular and Cell Biology, University of California, Berkeley)

    Regulation of TGF-ß and p53 in development and diseases

    The transforming growth factor-b (TGF-b) plays important roles in regulating embryonic and adult tissue development, normal tissue homeostasis and stem cell function.  Signaling through the Smad proteins, TGF-b pathway often crosstalks with multiple signaling pathways in a developmental stage- or...

  • Monday, 5th, September 2016 - Séminaire Speaker(s) : Flavio Maina ( IBDM (Developmental Biology Institute of Marseille), Aix-Marseille Université – CNRS UMR7288)

    Tracking RTK cooperative mechanisms during tumour initiation and evolution

      Aberrant receptor tyrosine kinase (RTK) signalling is essential during cancer evolution. However, it is unclear whether and how fluctuations of RTKs influence tumour initiation. We genetically addressed this issue by generating mice in which the expression of the wild-type RTK Met is conditi...

  • Tuesday, 6th, September 2016 - Séminaire CDC Speaker(s) : Gotha GOSHIMA

    Regulation of microtubule end dynamics on teh

    We are interested in intracellular dynamics, particularly those regulated by microtubules. The mitotic spindle is a research subject, and we have adopted multiple methodologies to understand the mechanism of spindle formation, most notably high-resolution live cell microscopy, high-throughput RNA...

  • Tuesday, 6th, September 2016 - Séminaire Speaker(s) : Benjamin LOPPIN (Laboratoire de Biométrie et Biologie Evolutive, UMR CNRS 5558, Lyon)

    Unlocking sperm chromatin at ferlilisation with a specialized egg thioredoxin

    The formation of a diploid zygote from two highly different gametes is a critical aspect of sexual reproduction in animals. Notably, the transmission of the paternal genome implies unique chromatin reorganization events that take place during spermiogenesis and at fertilization. Dr. Loppin's  gro...

  • Wednesday, 7th, September 2016 - Séminaire Speaker(s) : Peter Schlögelhofer (Department of Chromosome Biology, Max F. Perutz Laboratories, University of Vienna)

    Understanding and controlling meiotic recombination in Arabidopsis thaliana

    Research in the Schlögelhofer lab focuses on meiotic recombination in the model plant Arabidopsis thaliana. We are interested in the cis and trans determinants of meiotic DNA double strand break (DSB) formation, DSB processing, the establishment of inter-homologue bias during meiotic homologo...

  • Thursday, 8th, September 2016 - Séminaire CDC Speaker(s) : Andrea MUSACCHIO (Department of Mechanistic Cell Biology, Max-Planck-Institute of Molecular Physiology, Dortmund, Germany)

    Feedback control of mitosis: Learning from biochemical reconstitution

    During cell division, each daughter cell receives from its mother cell an exact, full copy of the genome. For this to happen, the sister chromatids in the mother cell must bi-orient on the mitotic spindle. Sister chromatid separation at the metaphase-to-anaphase transition leads to equal segregat...

  • Friday, 9th, September 2016 - Séminaire Curie TechWatch Speaker(s) : Mark D. Lynch ( Fluidigm )

    From single-cell transcriptomics to functional single-cell analysis

    Single-cell biology endeavors to unravel biological systems with high resolution. The C1™ system delivers an easy, complete workflow that captures and prepares individual cells for gene expression and multiple flavors of mRNA sequencing.  This means the community can use the C1 system to...

  • Monday, 12th, September 2016 - Séminaire Speaker(s) : Olivier Madar (Département de Radio-Pharmacologie, Institut Curie-Hôpital René Huguenin (Saint-Cloud))

    Apports de la RadioPharmacologie dans le développement de nouveaux médicaments

    L'imagerie moléculaire améliore par ces propriétés la prise en charge des cancers et des maladies neurologiques. Elle permet l'identification non invasive de cibles moléculaires, d'évaluer la distribution et la quantification d'un composé thérapeutique dans la tumeur et dans les organes. Ceci per...

  • Friday, 16th, September 2016 - Séminaire Orsay series Speaker(s) : Ze'ev Ronai

    Ubiquitin Ligases in Metabolism, Immune Checkpoint and Resistance to Therapy


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