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  • Mardi 26 Septembre 2017 - Séminaire Orateur(s) : Todd NYSTUL (UCSF)

    Survival of the fittest: a Drosophila model of epithelial stem cell niche competition

    The follicular epithelium in the Drosophila ovary is an ideal model for the study of epithelial biology. It possesses many classical epithelial features, such as a columnar cell shape, apical/basal polarity, and canonical cell adhesion complexes, and yet is a relatively simple tissue and is highl...

  • Mercredi 27 Septembre 2017 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Hans Clevers (Hubrecht Institute, Utrecht, the Netherlands)

    Stem cell-grown organoids as models for human disease

    The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. We originally defined Lgr5 as a Wnt target gene, transcribed in colon cancer cells. Two knock-in alleles revealed exclusive expression of Lgr5 in cycling, columnar cells at the crypt base. Using lineage tracing e...

  • Mercredi 27 Septembre 2017 - Séminaire Physico-Chimie Orateur(s) : Jeroen van Zon (AMOLF, Amsterdam)

    Robustness and variability in C. elegans organ development

    It is an open question how development can result in highly reproducible structures despite strong intrinsic variability on the molecular and cellular level. The anchor cell organizes the development of the reproductive organs of the nematode C. elegans. In this talk, I will discuss two events in...

  • Jeudi 28 Septembre 2017 - Séminaire Orateur(s) : Anna Goldenberg

    Bayesian methods for elucidating mechanisms and predicting treatment in complex human diseases

    There is a great potential for machine learning to contribute to understanding and curing complex human diseases. A lot of the questions we are faced with as a community are fairly complex, while the available data to answer these questions is relatively shallow (very large p, small n). Structura...

  • Vendredi 29 Septembre 2017 - Séminaire Nuclear dynamic series Orateur(s) : Ann EHRENHOFER-MURRAY (Humboldt Universität zu Berlin, Institut für Biologie, Berlin (Germany))

    regulation of centromere function by posttranslational modifications on the centromeric histone variant CENP-A/Cse4

    Dr. Ehrenhofer-Murray's lab focuses on how eukaryotic cells package their genetic material, the DNA, in chromatin in the nucleus. Differences in chromatin packaging dictate when and where genes are expressed, or whether genomic regions become permanently repressed (silenced). They study the molec...

  • Lundi 2 Octobre 2017 - Séminaire Orateur(s) : Catherine Potenski, Brooke LaFlamme

    Editorial Decision Making in High Impact Science

    Catherine Potenski, Editor of Nature Genetics and Brooke LaFlamme, recently named Editor in Chief of the new Nature journal Communications Biology will be visiting Institut Curie 2nd October to talk about the editorial process at scientific journals.  

  • Mardi 3 Octobre 2017 - Séminaire Nuclear dynamic series Orateur(s) : Mary DASSO (Eunice Kennedy Shriver National Institute for Child health and Human Development (NICHD) - NIH, Bethesda (MD, USA))

    New insights into an old friend: The many roles of the nuclear pore complex in regulating nuclear functions

    Dr. Dasso's lab is interested in mechanisms of chromosome segregation, defects in which lead to aneuploidy, that is, an abnormal number of chromosomes. Several common birth defects, such as Down's syndrome, result from aneuploidy arising during meiotic cell divisions. Moreover, aneuploidy arising...

  • Lundi 9 Octobre 2017 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Jürgen Knoblich (Institute of Molecular Biotechnology (IMBA), Vienna, Austria)

    Neural stem cells and brain development: From Drosophila to humans

    The human brain is the most fascinating and most complex organ of all. Despite this enormous complexity, the billions of neurons in our brain arise from a limited number of progenitors following a specific set of lineage decisions. We combine Drosophila genetics with 3D organoid cultures derived ...

  • Lundi 9 Octobre 2017 - Séminaire Orateur(s) : Edwin MUNRO (Department of Molecular Genetics and Cell Biology, University of Chicago)

    Dynamical basis for self-organizing cortical polarity in early C. elegans embryos.

    We are using the C. elegans zygote as a model to understand basic principles that govern self-organizing cortical polarity.  Zygotic polarity is specified by the asymmetric enrichment of highly conserved polarity determinants, known as PAR proteins, into complementary anterior and posterior corti...

  • Mardi 10 Octobre 2017 - Mini-colloquium

    “Book Marking” & Mitotic/Meiotic Inheritance

    Organised by Danny Reinberg, Howard Hughes Medical Institute, NYU Langone School of Medicine at Smilow Research Center, New York, USA (Sabbatical 2017 - Blaise Pascal Research Chair) With Edith Heard, UMR3215/U934 and Geneviève Almouzni, Dir. Of the Research Center, UMR3664, Institut Curie ...

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