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  • Tuesday, 27th, September 2016 - Séminaire Speaker(s) : Joel A. Swanson (Professor of Microbiology and Immunology, University of Michigan Medical School (Ann Arbor, Michigan, USA))

    Macropinosomes as Discrete Units of Signal Transduction

    Macropinocytosis is an endocytic process which efficiently delivers extracellular solutes into lysosomes. It can be induced in cells by growth factors, phorbol esters, chemokines, and many microbial pathogens. Macropinosomes form in stimulated cells by actin-based ruffling and membrane closure in...

  • Tuesday, 27th, September 2016 - Séminaire Speaker(s) : Robert Kay (MRC Laboratory of Molecular Biology (Cambridge, England))

    Disentangling the roles of Ras and PIP3 in macropinocytosis and chemotaxis

    We are interested in two major overlapping cell-biological processes: chemotaxis and macropinocytosis. Chemotaxing cells move by extending pseudopods or blebs, which they use to gain traction from their surroundings, and so pull their body forward. They can be guided by attractive chemicals in th...

  • Wednesday, 28th, September 2016 - Séminaire Physico-Chimie Speaker(s) : Ken Duffy ( Maynooth University, Dublin, Ireland)

    T cell stimuli integration at the level of clones

    In the presence of antigen and costimulation T cells undergo a characteristic response of expansion, cessation and contraction. Recent studies have revealed that population-level reproducibility is a consequence of multiple clones exhibiting considerable disparity in burst-size, highlighting the ...

  • Thursday, 29th, September 2016 - Séminaire Speaker(s) : Ramon Vilar

    Targeting and imaging G-quadruplex DNA with small molecules

    With the mounting evidence that non-canonical DNA structures play key biological roles, there is considerable interest in developing optical probes that can selectively detect and image specific DNA structures and topologies. In particular, over the past few years there has been increasing intere...

  • Monday, 3rd, October 2016 - Séminaire Speaker(s) : Suvendra N. Bhattacharyya (CSIR-Indian Institute of Chemical Biology (Kolkata, India))

    Mechanisms of controlling miRNA activity and abundance in mammalian cells

    miRNAs are tiny regulatory RNAs that repress gene expression in metazoan animal cells by base pairing to the target mRNAs. miRNA-target messages are repressed translationally and are subsequently getting degraded post repression. Although miRNAs regulate almost half of the protein coding mRNAs in...

  • Monday, 3rd, October 2016 - Séminaire Speaker(s) : Julian Sale (MRC Laboratory of Molecular Biology - Cambridge, UK)

    Epigenetic instability induced by replication of structured DNA

    My talk will focus on the interaction between DNA secondary structures and the replication machinery and how problems handling these structures can lead to changes in the chromatin landscape and altered gene expression. I will discuss the evidence for a model in which replication fork stalling at...

  • Friday, 7th, October 2016 - Séminaire Speaker(s) : Caren NORDEN (MPI of Molecular Cell Biology and Genetics, Dresden)

    How single cell behavior drives retinal architecture and neuronal lamination

    Organogenesis in complex multicellular organisms involves tight regulation of the interplay between cell proliferation, tissue growth and cell rearrangements. To understand how organs develop, we must explain single-cell behaviors in the context of the developing tissue. In my lab, we explore the...

  • Monday, 10th, October 2016 - Cours international - séminaire Speaker(s) : Peter Lawrence (Cambridge University, UK)

    Lessons from a lifetime researching developmental biology

    Peter Lawrence, Cambridge University, UK This seminar is a part of the 7th course on "DEVELOPMENTAL BIOLOGY COURSE: From Stem Cells to Morphogenesis" (October 10-21, 2016) which takes place at Institut Curie - Paris, Amphitheater BDD. More information here. Organizers: A. Bardin, Y. Bellaïc...

  • Monday, 10th, October 2016 - Séminaire Immunology series Speaker(s) : Jon Kagan (Associate Professor of Pediatrics, Harvard Medical School (Boston, USA))

    Initiation of Innate Immunity and Host Defenses

    I have been studying Pattern Recognition Receptor signaling pathways as a means of understating the earliest events that initiate immunity to infection. Our work focuses on studies of the RIG-I like Receptor (RLR) and Toll-like Receptor (TLR) signaling networks, which operate to detect microorgan...

  • Monday, 10th, October 2016 - Cours international - séminaire Speaker(s) : Paul Trainor (Stowers Institute, Kansas City, USA)

    Neural Crest Cells: Evolution Development & Disease

    Paul Trainor, Stowers Institute, Kansas City, USA This seminar is a part of the 7th course on "DEVELOPMENTAL BIOLOGY COURSE: From Stem Cells to Morphogenesis" (October 10-21, 2016) which takes place at Institut Curie - Paris, Amphitheater BDD. More information here. Organizers: A. Bardin, Y...

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