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  • Lundi 23 Octobre 2017 - Séminaire Orateur(s) : Eric D. Siggia (Rockefeller University, NY, USA)

    Exploring embryonic patterning with colonies of human embryonic stem cells

    Human embryonic stem cells when confined within two dimensional micropatterns with diameters in the 0.5-1mm range and subject to uniform Wnt or BMP stimulation, will spontaneously form radially symmetric spatial patterns that recapitulate the proximal-distal axis of the mammalian embryo at the ti...

  • Lundi 23 Octobre 2017 - Séminaire institutionnel "Mayent - Rothschild" Orateur(s) : Madalena TARSOUNAS (University of Oxford, The CR-UK/MRC Oxford Institute for Radiation Oncology, Oxford UK)

    BRCA1 and BRCA2 Tumour Suppressors Protect against Endogenous Acetaldehyde Toxicity

    Maintenance of genome integrity requires the functional interplay between Fanconi anemia (FA) and homologous recombination (HR) repair pathways. Endogenous acetaldehyde, a product of cellular metabolism, is a potent source of DNA damage, particularly toxic to cells and mice lacking the FA protein...

  • Mardi 24 Octobre 2017 - Séminaire Orateur(s) : Will WOOD (Faculty of Biomedical Sciences - University of Bristol, UK)

    Detecting death and damage; understanding macrophage migration in vivo

    Professor Will Wood received a Ph.D. in Developmental Biology from University College London before moving to Instituto Gulbenkian de Ciencia, Portugal, to work as a postdoctoral fellow. In 2006 he started his own research laboratory in the Department of Biology and Biochemistry at the University...

  • Mercredi 25 Octobre 2017 - Séminaire Physico-Chimie Orateur(s) : Joshua WATERFALL (Institut Curie)

    Learning from rare tumors: genetic mechanisms of oncogenesis

    The study of rare cancers and clinical phenotypes can reveal therapeutic opportunities as well as novel fundamental biological mechanisms. We will discuss multi-platform genomic profiling and functional studies in high risk hairy cell leukemia, pediatric gastrointestinal stromal tumor, and osteos...

  • Jeudi 2 Novembre 2017 - Séminaire Orateur(s) : Benoit BRUNEAU (Institute of Cardiovascular Disease, Professor of Pediatrics, UCSF)

    Transcriptional regulation of heart formation

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  • Vendredi 17 Novembre 2017 - Séminaire Orateur(s) : Magali OLIVIER

    Séminaire Dr Magali OLIVIER

    Les signatures mutationnelles de sous-types moléculaires de tumeurs du sein dans l'étude PRECAMA (Premenopausal Breast Cancer in Latin American Women).

  • Mardi 21 Novembre 2017 - Séminaire CDC Orateur(s) : Gisou VAN DER GOOT

    Function and dynamics of a key post-translational modification, S-palmitoylation, with a focus on the ER

    Gisou van der Goot studied engineering at the Ecole Centrale de Paris, then did a PhD in Molecular Biophysics at the Nuclear Energy Research Center, Saclay, France, followed by a postdoc at the European Molecular Biology Laboratory (EMBL) in Heidelberg. She started her own group in 1994 in the de...

  • Mardi 21 Novembre 2017 - Séminaire Nuclear dynamic series Orateur(s) : Aurèle PIAZZA (Institut Pasteur)

    Multi-invasions-induced rearrangements: A molecular example of how hell can be paved with good intentions

    Inaccurate repair of broken chromosomes generates structural variants that can fuel evolution and inflict pathology. Homologous recombination (HR) seals DNA double strand breaks by using an intact donor molecule as a template for repair. As such it is considered a high fidelity repair mechanism. ...

  • Vendredi 24 Novembre 2017 - Séminaire Orateur(s) : Sara Sigismund (IFOM, Fondazione Istituto FIRC di Oncologia Molecolare)

    ER-PM contact sites control EGFR endocytosis and signaling

    The integration of distinct endocytic routes is critical to regulate receptor signaling. A non-clathrin endocytic pathway (NCE) of the epidermal growth factor receptor (EGFR) is activated at high ligand concentrations, in parallel to clathrin-mediated endocytosis (CME). EGFR-NCE requires receptor...

  • Mercredi 13 Décembre 2017 - Séminaire Orateur(s) : Kai Simons (Max Planck Institute for Molecular Cell Biology and Genetics Dresden, Germany)

    Can lipidomics be used to measure health and disease?

    Cell membranes have developed a tremendous complexity of lipids and proteins geared to perform the functions cells require. To facilitate these functions, the bilayer has evolved the propensity to segregate its constituents laterally. This capability is based on dynamic liquid-liquid immiscibilit...

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