Chromatin based regulation of telomere maintenance

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4th Annual Breast Cancer Day

Breast cancer research news in Curie and new perspectives If you wish to take part in the lunch please register by clicking here (before 17th March 2019). 8h30 – 8h45 Introduction Breast cancer in Curie : MSP and SIRIC, report - Martine Piccart and Sergio Roman Roman 8h45 &...

Mechanobiology of Biological Membranes: from Mechanotransduc​tion to Artificial Cells

 Biological membranes are involved in a large number of cellular processes including cell migration, membrane trafficking, and cell signaling. Significant amount of work have elucidated the molecular machineries that regulate dynamic membrane-based processes. In parallel, there are growing intere...

Endoplasmic Reticulum proteostasis in cancer development

Proteostasis imbalance is emerging as a major hallmark of cancer, driving tumor aggressiveness. Genetic and pharmacological evidence suggest that the endoplasmic reticulum (ER), a major site for protein folding and quality control, plays a critical role in cancer development. This concept is vali...

Drugging Ageing

Ageing is malleable to genetic, dietary and pharmacological interventions. Furthermore, its underlying mechanisms have proved to be conserved over long evolutionary distances. Ageing is the main risk factor for chronic and killer diseases, and in animal models interventions that ameliorate ageing...

10e Journée ROGER MONIER - Imaging: a revolution

Meeting co-sponsored by Gustave Roussy and Institut Curie that honors the memory of Professor Roger Monier, a prominent figure in French modern biology. This year, we celebrate the 10th edition, a scientific day meeting focuses on a forefront issues in cancer biology: « Imaging: a revolution »...

Structural and Biophysical Studies of non-canonical DNA

  This talk will cover two representative stories on our attempts to elucidate the structure of non-canonical DNA implicated in important biological processes. To accomplish this goal we used a variety of biophysical methods coupled with X-ray crystallography. The first project concerns (CAGAG...

NanoString nCouner direct digital counting - Flexible High Plex biomarker research without RT and amplification bias

Decoding and re-encoding MAPK fate decision signaling

Cells dynamically sense and respond to ever changing external stimuli through sophisticated signaling networks. Accordingly, signaling dynamics rather than steady states have been recently shown to control cell fate decisions. For multiple signaling systems, heterogeneous dynamic signaling states...

Understanding Leukemia through the Lens of Normal Development: Single-cell studies for Clinical Translation

Acute leukemia is the most common cancer of childhood and one of the most deadly due to relapsed disease. Predicting patients at high risk of relapse is an imperfect science and currently combines clinical features, somatic alterations and early response to therapy. Yet, despite this, for the 20%...