Seminars list
Integration of Glycomics, Development, and ImmunologyLudger Johannes has invited Pr Richard D. Cummings from Beth Israel Deaconess Medical Center Harvard Medical School to come and give a talk on "Integration of Glycomics, Development, and Immunology". He will also participate in the Pastor's course |
Probing the Mechanisms of Chromosome Segregation with C. elegansDuring cell division, accurate chromosome segregation ensures the genetic integrity of cells and organisms, and shields them against aneuploidy, a hallmark of many cancers. By using the nematode Caenorhabditis elegans, we have gained important insights into the machinery and mechanisms that contr... |
From Molecules to Helical Ribbons - Shape and Shape FluctuationsSelf assembly of molecules into supramolecular structures is an important process through which non trivial structures are formed in nano-metric scale. The resulting structure depends on chemical and physical principles that govern the process, and may be sensitive to the exact conditions in whic... |
Enhancing the visibility and accessibility of research : Open Access and bibliometricsAmandine Pluchet abordera entre autres : comment déposer une publication dans un archive ouverte (HAL, ArXiv….), publier dans une revue Open Access, l'utilisation des licences Créatives Communs pour diffuser sa production scientifique, les aspects de bibliométrie (usages, critères, indica... |
Motor neuron disease and microtubule cytoskeleton: highways and scaffolds for signalingMicrotubules (MTs) are structural components vital for important neuronal functions including neurite outgrowth and maintenance, as well as axonal trafficking and synaptic remodeling. Heterozygous missense mutations in specific tubulin genes, such as TUBA1, TUBB2B, and TUBB3 have been associated ... |
Lessons from Paramecium genome gymnastics : A dual histone H3 K9/K27 Polycomb protein ensures transposable element repressionIn animals and plants, the H3K9me3 and H3K27me3 chromatin silencing marks are deposited by different protein machineries and play distinct cellular roles. We show that the Enhancer-of-zeste-like protein Ezl1 from the unicellular eukaryote Paramecium tetraurelia, which exhibits significant sequenc... |
 Tuesday, February 5th, 2019 - Seminar Speaker(s) : Cindy Neuzillet (Institut Curie) Inter- and intra-tumoral heterogeneity and dynamics of cancer-associated fibroblasts in pancreatic ductal adenocarcinoma and implications for immune therapyCancer-associated fibroblasts (CAF) are orchestrators of the pancreatic ductal adenocarcinoma (PDAC) microenvironment. Stromal heterogeneity may explain differential pathophysiological roles of the stroma (pro- vs. anti-tumoral) in PDAC. We hypothesised that multiple CAF subtypes exist in PDAC th... |
Bradley R. Cairns: Chromatin and Transcription Dynamics in the Germline and Early EmbryosIf you would like to meet the speaker, please contact Deborah.Bourchis@curie.fr |
Senescence as a conundrum of life and deathAging is the major risk factor for many chronic diseases accounting for the bulk of morbidity, mortality, and health costs in the world. There is significant evidence that the accumulation of senescent cells can drive many phenotypes and pathologies associated with aging. How senescence mechanist... |
 Monday, February 11th, 2019 - Seminar Immunology series Speaker(s) : Gunnar Schotta (Biomedical Center, LMU Munich, Munich, Germany) Silencing Mechanisms of endogenous retrovirusesEpigenetic mechanisms regulate multiple aspects of normal development (stem cell maintenance, differentiation). Misregulation of epigenetic programs can result in aberrant development (cancer, aging). In this context we study the mechanisms of epigenetic gene regulation using a combination of mou... |