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  • Mardi 19 Février 2019 - Séminaire Cell Biology Series Orateur(s) : Xavier NICOL (Team Mechanisms of sensory map development - Institut de la Vision, Paris)

    Diversity and specificity of second messenger signals shaping neuronal connectivity


  • Mercredi 20 Février 2019 - Séminaire Orateur(s) : Volker Bormuth (Laboratoire Jean Perrin ( UMR 8237 ) Sorbonne Université)

    A Miniaturized Light-Sheet Microscopy for Whole-Brain Calcium Imaging during Physiological Vestibular Stimulation in Larval Zebrafish

    The vestibular apparatus provides animals with postural and movement-related information that is essential to adequately execute numerous sensorimotor tasks. In order to activate this sensory system in a physiological manner, one needs to macroscopically rotate or translate the animal's head, whi...

  • Mercredi 20 Février 2019 - Séminaire Orsay series Orateur(s) : Lukas Trantirek (Central European Institute of Technology, Masaryk University & Institute of Biophysics, Czech Academy of Sciences, Brno, Czech Republic )

    In-cell NMR spectroscopy: Monitoring of structure, stability, and interactions of DNA at high resolution in nuclei of living human cells.

    The structure, dynamics and interactions of nucleic acids, DNA in particular, sensitively respond to a broad range of environmental factors many of them being natively present in intracellular space.  In-cell NMR spectroscopy is a tailored adaptation of conventional high-resolution nuclear magnet...

  • Jeudi 21 Février 2019 - Séminaire Orateur(s) : Masaru Ishii (Department of Immunology and Cell Biology, Graduate School of Medicine, Osaka University, Osaka, Japan)

    Dynamics of immune cell migration and interaction visualized by intravital microscopy

    During the last decade, intravital optical microscopy has launched a new trend in the field of biology. By using this advanced imaging technique we have established a new system for visualizing in situ behavior of a diversity of living cells within intact tissues and organs. Among them, we succee...

  • Lundi 25 Février 2019 - Séminaire Orateur(s) : Alan D. D’Andrea

    PARP Inhibitor Resistance and Acquired Vulnerability

    Large-scale genomic studies have demonstrated that approximately 50% of high-grade serous ovarian cancers (HGSOCs) harbor genetic and epigenetic alterations in homologous recombination repair (HRR) pathway genes. The most commonly altered HRR genes are BRCA1 and BRCA2, followed by other Fanconi A...

  • Mardi 26 Février 2019 - Séminaire Cell Biology Series Orateur(s) : Vincent HYENNE (Tumor Biomechanics - INSERM UMR_S 1109 - Institut d’hématologie et d'immunologie, Strasbourg)

    Fate and function of tumor extracellular vesicles in vivo

    Extracellular vesicles (EVs), including exosomes, have emerged as novel mediators of cell/cell communication in multiple biological and pathological contexts. They are produced by all cell types, present in every body fluid and contain proteins and RNA (coding and non coding) able to change the p...

  • Mercredi 27 Février 2019 - Séminaire Orateur(s) : Charles Kervrann (Serpico Team / Inria - CNRS - Institut Curie - UPMC)

    Computational methods for fluorescence microscopy and cryo-electron tomography

    Computational methods for fluorescence microscopy and cryo-electron tomography Charles Kervrann Serpico Team / Inria - CNRS - Institut Curie - UPMC During the past two decades, biological imaging has undergone a revolution in the development of new light and electron microscopy techniques that al...

  • Lundi 4 Mars 2019 - Séminaire Orateur(s) : Sara Richter (Dept Molecular Medicine University of Padua, Italy)

    Presence, function and targeting of G-quadruplexes in the human immunodeficiency virus-1 (HIV-1)

    Presence, function and targeting of G-quadruplexes in the human immunodeficiency virus-1 (HIV-1)

  • Mardi 5 Mars 2019 - Séminaire Cell Biology Series Orateur(s) : James CONWAY

    Application of FRET biosensors to interrogate intracellular signalling cascades in living systems


  • Vendredi 8 Mars 2019 - Séminaire Orateur(s) : Amir Bitran (Harvard University - Biophysics)

    Amir Bitran : Rare codons coordinate co-translational protein folding to avoid misfolded intermediates

    In the cell, many proteins begin folding co-translationally. To ensure proper function, co-translational folding must allow proteins to rapidly reach their native state while avoiding potentially harmful misfolded intermediates. Here we provide evidence that this process may be regulated in vivo ...

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