Seminars list
Cell Size ControlCell size plays a crucial role in the function of various cell types throughout the human body, influencing organelle structure, biosynthesis, and surface transport processes. Although certain genes influencing cell size have been identified, the molecular mechanisms by which cell growth initiate... |
Nucleosomes and DNA methylation implications for immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome and cancersDNA methylation is a broadly observed epigenetic modification. As genomic DNA methylation profiles dynamically change during development and aging, alterations in DNA methylation patterns are linked to diseases such as cancers and immunodeficiency. ICF syndrome is characterized by hypomethylation... |
Molecular Imaging and Microphysiological Culture Systems towards Improved Radiotherapy GuidanceThe presentation will focus on our recent and ongoing work in the fields of MRI-guided radiotherapy (and sentinel node biopsy) and on the development of microphysiological culture systems for radiobiological studies. In close collaboration with Ferronova, our team is developing a family of MRI co... |
Learning dynamical models from stochastic trajectoriesThe dynamics of biological systems, from proteins to cells to organisms, is complex and stochastic. To decipher their physical laws, we need to bridge between experimental observations and theoretical modeling. Thanks to progress in microscopy and tracking, there is today an abundance of experime... |
Non-Coding GenomeThe NON-CODING GENOME course will explore the versatility of non-genic DNA elements and non-coding RNAs across a spectrum of cellular processes, in humans and model organisms, and their implication in physiology and disease. Internationally recognized experts will present their latest findings re... |
Coping with mechanical stress: tissue dynamics during development, homeostasis and repair.Abstract: During growth and development, tissue dynamics, such as tissue folding, cell intercalations and oriented cell divisions, are critical for shaping tissues and organs. However, less is known about how tissues regulate their dynamics during tissue homeostasis and repair, to maint... |
Cutting and Pasting DNA to Create our Adaptive Immune SystemV(D)J recombination is essential for generating the adaptive immune response and unlimited number of different antibodies and antigen receptors. Encoded by multiple V, D and J gene segments, antigen receptors are assembled by programmed double-stranded DNA cleavage and imprecise re-joining. RAG1/... |
THE GENERATION OF NEURONAL DIVERSITY AND ITS EVOLUTIONIn the Drosophila optic lobes, ~200 types of neurons organized as 800 columns process the inputs from 800 unit-eyes. We study how this variety of neurons is generated during development and how connectivity among these neurons is regulated The ~800 Neural stem cells in the medulla ... |
Active nematic order in morphogenesis of the HydraHydra is named after the mythological animal for its regenerative capabilities, but contrary to its mythological counterpart, it only regenerates one head when cut. Here we show that soft compression of head regenerating tissues induces the regeneration of viable, two headed animals. Topological ... |
In situ structures of muscle sarcomere and sarcomeric proteinsSarcomeres are force-generating and load-bearing devices of muscles. A precise molecular picture of how sarcomeres are built underpins understanding their role in health and diseases. We determined the molecular architecture of native skeletal and cardiac sarcomeres and structures of sarcomeric p... |