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 Mercredi 3 Juin 2020 - Séminaire Immunology series Orateur(s) : Bernard Malissen (Centre dImmunologie de Marseille-Luminy and Centre dImmunophénomique, Aix Marseille Universite) Quantitative interactomics of the TCR signal-transduction network helps designing coinhibitory-based immunotherapyThe activation of T cells by the T cell antigen receptor (TCR) results in the formation of signaling protein complexes (signalosomes), the composition of which has not been analyzed at system-level. We isolated primary T cells from 17 gene-targeted mice each expressing at physiological levels one... |
Multi-scale Systems Pharmacology to Personalize Anticancer Drug Combination and ScheduleThe quest for personalized cancer management has fostered the development of new technologies enabling the longitudinal assessment of patient- and tumor-specific features at the molecular, tissue and whole organism scales. To ensure the translation of these multi-type datasets into individualized... |