Liste des séminaires
Survival of the fittest: a Drosophila model of epithelial stem cell niche competitionThe follicular epithelium in the Drosophila ovary is an ideal model for the study of epithelial biology. It possesses many classical epithelial features, such as a columnar cell shape, apical/basal polarity, and canonical cell adhesion complexes, and yet is a relatively simple tissue and is highl... |
 Mercredi 27 Septembre 2017 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Hans Clevers (Hubrecht Institute, Utrecht, the Netherlands) Stem cell-grown organoids as models for human diseaseThe intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. We originally defined Lgr5 as a Wnt target gene, transcribed in colon cancer cells. Two knock-in alleles revealed exclusive expression of Lgr5 in cycling, columnar cells at the crypt base. Using lineage tracing e... |
Robustness and variability in C. elegans organ developmentIt is an open question how development can result in highly reproducible structures despite strong intrinsic variability on the molecular and cellular level. The anchor cell organizes the development of the reproductive organs of the nematode C. elegans. In this talk, I will discuss two events in... |
Bayesian methods for elucidating mechanisms and predicting treatment in complex human diseasesThere is a great potential for machine learning to contribute to understanding and curing complex human diseases. A lot of the questions we are faced with as a community are fairly complex, while the available data to answer these questions is relatively shallow (very large p, small n). Structura... |
regulation of centromere function by posttranslational modifications on the centromeric histone variant CENP-A/Cse4Dr. Ehrenhofer-Murray's lab focuses on how eukaryotic cells package their genetic material, the DNA, in chromatin in the nucleus. Differences in chromatin packaging dictate when and where genes are expressed, or whether genomic regions become permanently repressed (silenced). They study the molec... |
Editorial Decision Making in High Impact ScienceCatherine Potenski, Editor of Nature Genetics and Brooke LaFlamme, recently named Editor in Chief of the new Nature journal Communications Biology will be visiting Institut Curie 2nd October to talk about the editorial process at scientific journals. |
New insights into an old friend: The many roles of the nuclear pore complex in regulating nuclear functionsDr. Dasso's lab is interested in mechanisms of chromosome segregation, defects in which lead to aneuploidy, that is, an abnormal number of chromosomes. Several common birth defects, such as Down's syndrome, result from aneuploidy arising during meiotic cell divisions. Moreover, aneuploidy arising... |
 Lundi 9 Octobre 2017 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Jürgen Knoblich (Institute of Molecular Biotechnology (IMBA), Vienna, Austria) Neural stem cells and brain development: From Drosophila to humansThe human brain is the most fascinating and most complex organ of all. Despite this enormous complexity, the billions of neurons in our brain arise from a limited number of progenitors following a specific set of lineage decisions. We combine Drosophila genetics with 3D organoid cultures derived ... |
Dynamical basis for self-organizing cortical polarity in early C. elegans embryos.We are using the C. elegans zygote as a model to understand basic principles that govern self-organizing cortical polarity. Zygotic polarity is specified by the asymmetric enrichment of highly conserved polarity determinants, known as PAR proteins, into complementary anterior and posterior corti... |
 Mardi 10 Octobre 2017 - Mini-colloquium Book Marking & Mitotic/Meiotic InheritanceOrganised by Danny Reinberg, Howard Hughes Medical Institute, NYU Langone School of Medicine at Smilow Research Center, New York, USA (Sabbatical 2017 - Blaise Pascal Research Chair) With Edith Heard, UMR3215/U934 and Geneviève Almouzni, Dir. Of the Research Center, UMR3664, Institut Curie ... |