Seminars list
On the multiple roads to cell fate decisions: Integrating transcription factors into RNA-regulatory networksWhile the current view states that Transcription Factors (TFs) act on DNA regulatory elements to deploy precise gene programs, an emerging concept proposes that TFs also bind RNA and regulate splicing to promote molecular and cellular diversity. Yet, how the RNA regulatory functions of TFs contri... |
Scientific Publishing: Behind the Scenes at NatureA fundamental part of scientific research is publishing your research findings. But once you have submitted your paper to a journal, it can seem like a daunting black box regarding what actually happens to your paper and how authors can successfully navigate the various steps of the publication p... |
Demystifying Machine and Deep Learning and overview of their applications in biologyArtificial Intelligence is a broad term that is often misunderstood. Its subfields, such as machine and deep learning have achieved astonishing performances, such as some Large Language Models passing the Turing Test or AlphaFold offering a solution to a 50 years old problem. Because new technolo... |
THE GENERATION OF NEURONAL DIVERSITY AND ITS EVOLUTIONClaude Desplan1,2, Nikos Konstantinides1, Felix Simon1, Neset Ozel1, Isabel Holguera1, Jennifer Malin1, Yen Chen1, and Bogdan Sieriebriennikov1 1 Center for Developmental Genetics, Department of Biology, New York University, New York, USA; 2 Center for Genomics and System Biology, NYU Abu... |
Common threads in regeneration: mechano-chemical insights from a jellyfish modelHow randomly injured animals can appropriately re-establish positional information and control the deployment of repair programs are key questions of regenerative biology. The hydrozoan jellyfish Clytia hemisphaerica has recently emerged as an original model organism for probing repair phenomena,... |
Understanding and modeling agingAging is associated with a decline in tissue function and the onset of a constellation of diseases. We are interested in understanding aging, with a particular focus on brain aging. Because aging is complex, we use organisms with diverse lifespans – the worm C. elegans, the African killifis... |
Protect and recycle: how cells regulate dormancyOur research is focused on elucidating how cell growth and division are regulated in space and time, in particular by selective degradation of cellular components. Eukaryotic cells use autophagy and the ubiquitin-​proteasome system (UPS) to ensure cellular homeostasis, and recycle excess an... |
Deconstruct-Reconstruct Decode cancer-immune crosstalk & probe with organoids.The Roose team at UCSF studies mechanisms of cell-cell interactions in immunology and cancer1-7, with emphasis on personalized medicine4,8 and single cell approaches9-11. Over the past 7 years, we shifted a large portion of our research efforts to understanding human biology and disease. We are d... |
Nucleosomes and DNA methylation implications for immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome and cancersDNA methylation is a broadly observed epigenetic modification. As genomic DNA methylation profiles dynamically change during development and aging, alterations in DNA methylation patterns are linked to diseases such as cancers and immunodeficiency. ICF syndrome is characterized by hypomethylation... |
Non-Coding GenomeThe NON-CODING GENOME course will explore the versatility of non-genic DNA elements and non-coding RNAs across a spectrum of cellular processes, in humans and model organisms, and their implication in physiology and disease. Internationally recognized experts will present their latest findings re... |