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  • Lundi 13 Mai 2024 - Séminaire Orateur(s) : Jeroen Roose (University of California, San Francisco)

    “Deconstruct-Reconstruct” – Decode cancer-immune crosstalk & probe with organoids.

    The Roose team at UCSF studies mechanisms of cell-cell interactions in immunology and cancer1-7, with emphasis on personalized medicine4,8 and single cell approaches9-11. Over the past 7 years, we shifted a large portion of our research efforts to understanding human biology and disease. We are d...

  • Mardi 21 Mai 2024 - Séminaire Orateur(s) : Hironori Funabiki (The Rockefeller University, New York)

    Nucleosomes and DNA methylation – implications for immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome and cancers

    DNA methylation is a broadly observed epigenetic modification. As genomic DNA methylation profiles dynamically change during development and aging, alterations in DNA methylation patterns are linked to diseases such as cancers and immunodeficiency. ICF syndrome is characterized by hypomethylation...

  • Mercredi 29 Mai 2024 - Séminaire Orateur(s) : Pierre Ronceray

    Learning dynamical models from stochastic trajectories

    The dynamics of biological systems, from proteins to cells to organisms, is complex and stochastic. To decipher their physical laws, we need to bridge between experimental observations and theoretical modeling. Thanks to progress in microscopy and tracking, there is today an abundance of experime...

  • Vendredi 31 Mai 2024 - Séminaire Orateur(s) : Wei Yang (National Institute of Health - NIH)

    Cutting and Pasting DNA to Create our Adaptive Immune System

    V(D)J recombination is essential for generating the adaptive immune response and unlimited number of different antibodies and antigen receptors. Encoded by multiple V, D and J gene segments, antigen receptors are assembled by programmed double-stranded DNA cleavage and imprecise re-joining. RAG1/...

  • Mercredi 17 Juillet 2024 - Séminaire Orateur(s) : Jianping FU

    Bioengineering Human Embryo and Organ Models

    Early human development remains mysterious and difficult to study.  Recent advances in developmental biology, stem cell biology and bioengineering have contributed to a significant interest in constructing controllable, stem cell-based models of human embryo and organs (embryoids / organoids).  T...

  • Mardi 15 Octobre 2024 - Séminaire Orateur(s) : Sara Lucia Giustina Sigismund

    Endocytic control of cell plasticity in cancer

    Over the past two decades, there has been a significant shift in our understanding of the role of endocytosis and trafficking of signaling receptors. It has evolved from being viewed simply as a signal extinguisher (resulting in long-term attenuation) to being recognized as a sophisticated mechan...

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