Early career. I obtained my PhD in The Netherlands where I investigated Wnt signaling and cancer in the lab of Breakthrough Prize in Life Sciences recipient Dr. Hans Clevers. I subsequently studied Ras signaling in lymphocytes during my postdoc in the lab of HHMI investigator Dr. Arthur Weiss at UCSF. In 2007, I started my own research at UCSF, initially focusing on signaling pathways and cell fate choices.

Current career. I am currently fulfilling leadership positions in my home department, in ImmunoX, in three large research programs, and at UCSF. I am a tenured Professor and Vice Chair of Anatomy. I am a co-founder of UCSF's Bakar ImmunoX Immunology Program, co-lead on UCSF’s AutoIPI (AutoImmunoProfiler) funded by a Pharma consortium, co-lead on the UCSF Endeavor program funded by the Mark Foundation for Cancer research, and Lead-PI on a P01. Program grant in its third cycle funded by NIAID, NIH. I am co-director for a medical school course and a graduate school course and I serve on numerous committees at UCSF.

Roose lab – research. The Roose lab focuses on understanding cell fitness and cell fate decisions driven by cell-cell interactions and signaling pathways, in the context of stem cell biology, cancer, and autoimmune diseases. By taking a collaborative approach working with biophysicists, engineers, geneticists, and many clinicians, our team spans the gamut from fundamental to pre-clinical science. I am a recipient of multiple grants and awards including support from the NIH, foundations, philanthropy and industry