Liste des séminaires
![]() Epigenetics: from human pluripotent stem cell models of neurodegenerative diseases to recent human evolutionIn the first part, I will discuss juvenile and infantile forms of human pluripotent stem cell (hPSC) isogenic models for Huntington's disease (HD), the most common poly-glutamine (polyQ) related disorder. HD is caused by CAG (encoding glutamine, Q) expansions within the Huntingtin (HTT) gene. The... |
![]() Epigenetics: from pluripotent stem cells to ancient DNAPluripotent embryonic stem cells (ESCs) are characterized by a unique, globally decondensed, chromatin structure. In the first and main part will describe our endogenously-tagged fluorescent-fusion protein libraries in mouse ESCs, which we used to screen for potential regulators of pluripotency a... |