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Séminaire
Epigenetics: from pluripotent stem cells to ancient DNA
Pluripotent embryonic stem cells (ESCs) are characterized by a unique, globally decondensed, chromatin structure. In the first and main part will describe our endogenously-tagged fluorescent-fusion protein libraries in mouse ESCs, which we used to screen for potential regulators of pluripotency and early ESC differentiation. I will discuss two prominent hits which we identified: a nuclear protein, SET, involved in regulation of pluripotency and early development, and a cytoplasmic protein, CAPRIN1, involved in degrading developmental RNA transcripts during early ESC differentiation.
In the second part, I will more briefly discuss our recent work on paleo-epigenetics, where we are reconstructing DNA methylation in ancient DNA. This technique allows us to identify differentially methylated genes between modern and archaic humans, and more recently, between pre- and post-Neolithic societies.
Orateur(s)
Prof.
Department of Genetics, The Institute of Life Science & The Edmond and Lily Safra Center for Brain Sciences (ELSC), The Hebrew University of Jerusalem
Invité(e)(s) par
Institut Curie