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  • Lundi 23 Octobre 2017 - Séminaire institutionnel "Mayent - Rothschild" Orateur(s) : Madalena TARSOUNAS (University of Oxford, The CR-UK/MRC Oxford Institute for Radiation Oncology, Oxford UK)

    BRCA1 and BRCA2 Tumour Suppressors Protect against Endogenous Acetaldehyde Toxicity

    Maintenance of genome integrity requires the functional interplay between Fanconi anemia (FA) and homologous recombination (HR) repair pathways. Endogenous acetaldehyde, a product of cellular metabolism, is a potent source of DNA damage, particularly toxic to cells and mice lacking the FA protein...

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