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  • Wednesday, 28th, February 2024 - Séminaire institutionnel "Mayent - Rothschild" Speaker(s) : Dan Larson

    Spliceosome Mutations in Myeloid Malignancy

    The primary goal of Dan Larson's laboratory is to understand gene expression in eukaryotic cells, starting from the mechanistic behavior of individual macromolecules and proceeding to their regulation in cells and tissue. The laboratory utilizes a battery of biophysical, molecular and genomic ap...

  • Thursday, 21st, March 2024 - Séminaire institutionnel "Mayent - Rothschild" Speaker(s) : Michael LICHTEN (Laboratory of Biochemistry and Molecular Biology, CCR, National Cancer Institute, Bethesda, USA)

    A garden of forking paths: branching, switching and reversal in meiotic recombination

    Meiotic recombination involves repair of double strand DNA breaks by homologous recombination to form crossovers and noncrossovers. Current models suggest that different mechanisms form these two products: noncrossovers by synthesis dependent strand annealing; COs by double Holliday junction form...

  • Friday, 5th, April 2024 - Séminaire institutionnel "Mayent - Rothschild" Speaker(s) : Michael Lichten (National Cancer Institute - Center for Cancer Research)

    A garden of forking paths: branching, switching and reversal in meiotic recombination

    Abstract Meiotic recombination involves repair of double strand DNA breaks by homologous recombination to form crossovers and noncrossovers. Current models suggest that different mechanisms form these two products: noncrossovers by synthesis dependent strand annealing; COs by double Holliday j...

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