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Séminaire
When Nuance Matters: The lesser known side of PD1 signaling
The inhibitory immunoreceptor PD1 is a major cancer immunotherapy target. Anti-PD1 blockade antibodies have become the standard of care for cancer patients, but the low response rate and associated immune related side effects necessitate a better understanding of PD1 mechanism. Best known to be expressed by T cells, PD1 transduces inhibitory signals to attenuate T cell response upon binding to its ligand PDL1. In this seminar I will share our ongoing studies on the unexpected nuances in the signaling mechanism of PD1.
Orateur(s)
Associate Professor
Department of Cell and Developmental Biology, UCSD, San Diego
Invité(e)(s) par
Institut Curie
Institut Curie