Liste des séminaires
A network of lipid-transfer proteins at the crossroads between metabolism and signallingLipid metabolism attracts much attention owing to the pleiotropic roles of lipids and their implication in human pathologies, and this interest motivates growing efforts dedicated to cataloguing the lipidome. However, all aspects of lipid function rely on their heterogeneous distribution in livin... |
Developmental reprogramming: how to make an epigenetically "naïve" state“Epigenetic reprogramming encompasses changes in nuclear architecture and epigenetic modifications that eventually lead to a shift in gene expression profile” |
Architecture and dynamics of meiotic chromosome structures and recombination sitesResearch in the Villeneuve lab is aimed at understanding the molecular and cellular mechanisms underlying the faithful inheritance eukaryotic chromosomes. Our primary focus is on elucidating the events required for the orderly segregation of homologous chromosomes during meiosis, the crucial proc... |
Ligands for the immune activating receptor NKG2D: different features affecting NK cell responseNatural Killer (NK) cells play a key role in tumor control, and recognition by the activating receptor NKG2D of its ligands is particularly important for this activity, since although absent on healthy cells, NKG2D ligands (NKG2D-L) are expressed by stressed cells in different pathological situat... |
Unraveling the tumor microenvironment architecture by multispectral imagingThe natural history of cancer involves interactions between the tumor and the immune defense mechanism of the host. The crucial role of the patient's own immune system on clinical outcome is demonstrated by the immunological characterization of the tumor microenvironment. The analysis of type, lo... |
 Vendredi 1 Juin 2018 - Séminaire Orateur(s) : Damien ARNOULT (INSERM U542, Hopital Paul Brousse, Universite Paris Sud) A cytosolic unfolded protein response controls innate immune signalingMultiple cytosolic innate sensors form large oligomers following activation, yet this assembly needs to be tightly regulated to avoid accumulation of misfolded aggregates. We observed that the eIF2α kinase of the highly conserved integrated stress response (ISR) pathway, heme-regulated inhi... |
DNA Damage in G-Quadruplexes Regulates Gene Expression via Base Excision RepairInterplay between DNA repair of the oxidatively modified base 8-oxo-7,8-dihydroguanine (OG) and transcriptional activation has been observed in the VEGF, TNF-α, SIRT1, and BCL2 genes. We synthesized OG into the VEGF potential G-quadruplex sequence (PQS) in the coding strand of a lucif... |
High parameter single-cell proteins and RNAs analysis: from new technologies to cancer immunologyThe goal of this seminar is to give an overview on my past work, as well as to introduce the questions that my group will aim at addressing. I will showcase few single-cell technologies that my colleagues and I have developed at Stanford University, which apply to multiplexed imaging, mass cyt... |
Single-cell (multi-omics) sequencing to study cellular heterogeneity in health and diseaseThierry Voet, co-founder and group leader of the Sanger Institute-EBI Single-Cell Genomics Centre, Hinxton, UK and Associate Professor of the KU Leuven, Belgium, will be visiting the Institut Curie on Feb 2 and giving a seminar entitled: “Single-cell (multi-omics) sequencing to study cellu... |
Life after PhD Career Support and Gender EqualityGerlind Wallon is the deputy director of the European Molecular Biology Organization (EMBO). A German native, she graduated with a PhD in Biochemistry from Brandeis University, Waltham, Massachusetts, USA, followed by a post-doctoral period at EMBL in Heidelberg. At EMBO she is responsible for... |