Seminars list
"Paired multiplex imaging and spatial transcriptomics to decipher the tumor cells-fibroblasts crosstalk in lung and head & neck cancer "Already the 10th seminar of the series ! For this session, we will host Helene Salmon , head of the Stroma and Immunity lab in Curie (U932). She will present their insights in paired multiplex imaging and spatial transcriptomics to decipher the tumor cells-fibroblasts crosstalk in lung and head &... |
The dangerous combination of DNA structures and chromosome gaps: implications for repeat instability and cell survivalThe Freudenreich lab uses the yeast Saccharomyces cerevisiae (baker's yeast) as a model organism to study genome instability. In particular, we investigate the molecular basis of two related types of DNA mutations: repeat expansions and chromosome fragility. Expansion of repeat sequences is the... |
Double Raphael - Double Trouble - Double Impact"How homologous recombination (HR)-deficient tumors survive genomic instability" Abstract Gaining recognition in the last few years, alternative DNA repair pathways were recently shown to be required for cancer cell viability in the absence of homologous recombination (HR)-mediated... |
![]() Cutting and Pasting DNA to Create our Adaptive Immune SystemV(D)J recombination is essential for generating the adaptive immune response and unlimited number of different antibodies and antigen receptors. Encoded by multiple V, D and J gene segments, antigen receptors are assembled by programmed double-stranded DNA cleavage and imprecise re-joining. RAG1/... |