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  • Mercredi 23 Mai 2018 - Séminaire Orateur(s) : Anne-Claude Gavin (EMBL - Group Biochemical networks in health and diseases)

    A network of lipid-transfer proteins at the crossroads between metabolism and signalling

    Lipid metabolism attracts much attention owing to the pleiotropic roles of lipids and their implication in human pathologies, and this interest motivates growing efforts dedicated to cataloguing the lipidome. However, all aspects of lipid function rely on their heterogeneous distribution in livin...

  • Mercredi 23 Mai 2018 - Séminaire Orateur(s) : Petra HAJKOVA (MRC London Institute of Medical Sciences)

    Developmental reprogramming: how to make an epigenetically "naïve" state

    “Epigenetic reprogramming encompasses changes in nuclear architecture and epigenetic modifications that eventually lead to a shift in gene expression profile”

  • Jeudi 24 Mai 2018 - Séminaire Orateur(s) : Anne Villeneuve (Genetics and Developmental Biology, Developmental Biology Department, Stanford University, USA)

    Architecture and dynamics of meiotic chromosome structures and recombination sites

    Research in the Villeneuve lab is aimed at understanding the molecular and cellular mechanisms underlying the faithful inheritance eukaryotic chromosomes. Our primary focus is on elucidating the events required for the orderly segregation of homologous chromosomes during meiosis, the crucial proc...

  • Mercredi 30 Mai 2018 - Séminaire Orateur(s) : Sheila López-Cobo (Autónoma University, Madrid, Spain)

    Ligands for the immune activating receptor NKG2D: different features affecting NK cell response

    Natural Killer (NK) cells play a key role in tumor control, and recognition by the activating receptor NKG2D of its ligands is particularly important for this activity, since although absent on healthy cells, NKG2D ligands (NKG2D-L) are expressed by stressed cells in different pathological situat...

  • Mercredi 30 Mai 2018 - Séminaire Orateur(s) : Angela Vasaturo (INSERM UMRS1138 Integrative Cancer Immunology / Cordeliers Research Center)

    Unraveling the tumor microenvironment architecture by multispectral imaging

    The natural history of cancer involves interactions between the tumor and the immune defense mechanism of the host. The crucial role of the patient's own immune system on clinical outcome is demonstrated by the immunological characterization of the tumor microenvironment. The analysis of type, lo...

  • Vendredi 1 Juin 2018 - Séminaire Orateur(s) : Damien ARNOULT (INSERM U542, Hopital Paul Brousse, Universite Paris Sud)

    A cytosolic unfolded protein response controls innate immune signaling

    Multiple cytosolic innate sensors form large oligomers following activation, yet this assembly needs to be tightly regulated to avoid accumulation of misfolded aggregates. We observed that the eIF2α kinase of the highly conserved integrated stress response (ISR) pathway, heme-regulated inhi...

  • Mardi 5 Juin 2018 - Séminaire Orateur(s) : Cynthia J. Burrows (Department of Chemistry, University of Utah, 315 S. 1400 East, Salt Lake City, UT 84112-0850, USA)

    DNA Damage in G-Quadruplexes Regulates Gene Expression via Base Excision Repair

         Interplay between DNA repair of the oxidatively modified base 8-oxo-7,8-dihydroguanine (OG) and transcriptional activation has been observed in the VEGF, TNF-α, SIRT1, and BCL2 genes.  We synthesized OG into the VEGF potential G-quadruplex sequence (PQS) in the coding strand of a lucif...

  • Mercredi 6 Juin 2018 - Séminaire Orateur(s) : Alessio BAVA (Institut Curie)

    High parameter single-cell proteins and RNAs analysis: from new technologies to cancer immunology

    The goal of this seminar is to give an overview on my past work, as well as to introduce the questions that my group will aim at addressing. I will showcase few single-cell technologies that my colleagues and I have developed at Stanford University, which apply to multiplexed imaging, mass cyt...

  • Mercredi 6 Juin 2018 - Séminaire Orateur(s) : Thierry VOET (Sanger Institute - EBI Single-Cell Genomics Centre, Hinxton, UK & Associate Professor at the University of Leuven (KU Leuven), Belgium)

    Single-cell (multi-omics) sequencing to study cellular heterogeneity in health and disease

    Thierry Voet, co-founder and group leader of the Sanger Institute-EBI Single-Cell Genomics Centre, Hinxton, UK  and Associate Professor of the KU Leuven, Belgium, will be visiting the Institut Curie on Feb 2 and giving a seminar entitled: “Single-cell (multi-omics) sequencing to study cellu...

  • Jeudi 7 Juin 2018 - Séminaire

    Life after PhD…Career Support and Gender Equality

    Gerlind Wallon is the deputy director of the European Molecular Biology Organization (EMBO). A German native, she graduated with a PhD in Biochemistry from Brandeis University, Waltham, Massachusetts, USA, followed by a post-doctoral period at EMBL in Heidelberg. At EMBO she is responsible for...

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