Liste des séminaires
Coupling and Uncoupling Transcription with TranslationWe show that transcription and translation are physically coupled in E.coli by the NusG protein. The NTD of NusG binds RNAP, whereas its CTD binds ribosomal protein S10. We present a cryo-EM structure showing NusG CTD bound to S10 in an intact 70S ribosome. We find that NusG is required for coupl... |
Assessing the engines of affinity maturation to vaccines: germinal centers and Tfh cellsT cell help to B cells was one of the earliest discovered functions of T cells, 49 years ago, resulting in the coining of the term ‘helper cell'. Follicular helper T cells (Tfh) are the specialized CD4 T cells for B cell help. Generation of long term humoral immunity is a complex process pr... |
Tuft cells : intestinal epithelial sentinels linking luminal danger to immune responses- Gerbe F., Sidot E., Smyth D. J., Ohmoto M., Matsumoto I., Dardalhon V., Cesses P., Garnier L., Pouzolles M., Brulin B., Bruschi M., Harcus Y., Zimmermann V. S., Taylor N., Maizels R. M. and Jay P. : Intestinal epithelial tuft cells initiate type 2 mucosal responses to helminth parasites. Nature... |
Ultraviolet A-induced oxidation in the cornea: short and long-term effectsHuman eye is directly exposed to solar ultraviolet (UV) radiations but the retina is protected from those rays. Indeed, the cornea and the lens filter UV rays to protect the retina against their toxicity. The UVA component represents 95% of solar UV radiation and has photo-oxidant properties. How... |
Making two equal one: Human X-chromosome inactivation. |
Structural characterisation of G protein-coupled receptors, What have we learnt?G Protein Coupled receptors (GPCRs) are integral membrane protein and constitute the largest family of membrane proteins. GPCRs are localised at the plasma membrane of eukaryotic cells. They mediate signal transduction from the extracellular to the intracellular compartment and play an important ... |
ER-PM contact sites control EGFR endocytosis and signalingThe integration of distinct endocytic routes is critical to regulate receptor signaling. A non-clathrin endocytic pathway (NCE) of the epidermal growth factor receptor (EGFR) is activated at high ligand concentrations, in parallel to clathrin-mediated endocytosis (CME). EGFR-NCE requires receptor... |