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  • Thursday, 24th, October 2019 - Séminaire Speaker(s) : Doug WINTON (CRUK Cambridge Institute and University of Cambridge)

    The clone dynamics resulting from stem cell renewal in colonic epithelium

    Stem cell and clonality : Renewing tissues are maintained by the production of cells by a small populations of founder stem cells. It follows that of the cells undergoing mutation it is the stem cells are the most likely to give rise to clones that become fixed. Moreover, pre-cancerous lesions ma...

  • Wednesday, 20th, November 2019 - Séminaire Speaker(s) : Allyson Sgro (Boston University)

    Who Said To Do That? Understanding Multicellular Decision Making

    Coordinating behaviors across groups of cells is critical for a wide range of biological processes ranging from development to wound healing.  How these basic group phenomena are regulated at the level of single cells, potentially by modulating factors like the frequency of synchronized signaling...

  • Friday, 29th, November 2019 - Séminaire Speaker(s) : Matthieu Perreau (Lausanne University Hospital, Lausanne, Switzerland)

    Role of T follicular helper cells in HIV-1 persistence

    Increasing number of evidences indicate that B-cell follicles might be anatomical sanctuaries for active and persistent transcription in both HIV/SIV viremic controllers and in ART treated aviremic HIV-infected individuals and have underscored the importance of the delineation of mechanisms allow...

  • Wednesday, 11th, December 2019 - Séminaire Speaker(s) : Jean Louis Mergny (Institut Curie)

    Quadruplexes are everywhere!

         A number of non-classical pairing patterns are possible between or within DNA and RNA strands. These interactions result in the formation of unusual structures, among them G-quadruplexes and i-motifs. G-quadruplexes (G4) result from the stacking of several G-quartets (formed by hydrogen bond...

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