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  • Friday, 31st, May 2024 - Séminaire Speaker(s) : Wei Yang (National Institute of Health - NIH)

    Cutting and Pasting DNA to Create our Adaptive Immune System

    V(D)J recombination is essential for generating the adaptive immune response and unlimited number of different antibodies and antigen receptors. Encoded by multiple V, D and J gene segments, antigen receptors are assembled by programmed double-stranded DNA cleavage and imprecise re-joining. RAG1/...

  • Monday, 3rd, June 2024 - Séminaire Speaker(s) : Patrice Gouet (Institut de Biologie et Chimie des Protéines)

    Le nouveau serveur web FoldScript, exploitant le meilleur des modèles AlphaFold : cas de test des complexes protéiques IN:IN et RT:IN du HIV-1

    Les programmes de modélisation 3D utilisant l'intelligence artificielle (IA) ont révolutionné la biologie structurale, permettant souvent de prédire les structures des protéines avec des niveaux de confiance sans précédent. Cependant, ces structures restent des modèles, et il est toujours intéres...

  • Wednesday, 5th, June 2024 - Séminaire Speaker(s) : Robert Arkowitz

    Probing morphogenesis and drug susceptibility at multiple scales, in a human fungal pathogen

    We have been focusing on the yeast to hyphal transition, as well as subsequent filamentous growth, both that of the main filament apex and filament branching, in the human fungal pathogen, Candida albicans. Filament branching results in an increase in the number of growth sites and may play a ...

  • Wednesday, 5th, June 2024 - Séminaire Speaker(s) : Paule Dagenais

    Mechanical positional information guides the self-organized development of a polygonal network of creases in the skin of mammalian noses

    The glabrous skin of the rhinarium (naked nose) of many mammalian species exhibit a polygonal pattern of grooves that retain physiological fluid, thereby keeping their nose wet and, among others, facilitating the collection of chemosensory molecules. In this talk, I will discuss how rhinarial pol...

  • Friday, 7th, June 2024 - Séminaire Speaker(s) : Aurélien Roux

    Active nematic order in morphogenesis of the Hydra

    Hydra is named after the mythological animal for its regenerative capabilities, but contrary to its mythological counterpart, it only regenerates one head when cut. Here we show that soft compression of head regenerating tissues induces the regeneration of viable, two headed animals. Topological ...

  • Monday, 10th, June 2024 - Séminaire Speaker(s) : Dolores Di Vizio (Cedars-Sinai Medical Center)

    Functional and molecular characterization of cancer-derived extracellular vesicles

    Cancer-derived extracellular vesicles have been demonstrated to play a crucial role in cancer biology. Our team is particularly interested in cancer EV heterogeneity and we have been studying a particular population of extracellular vesicles, known as large oncosomes. These EVs are released by ag...

  • Friday, 14th, June 2024 - Séminaire Speaker(s) : Anne Bowcock

    Defining the roles of genetic drivers of uveal melanoma with cell-based and Drosophila models

    Uveal melanoma is the most common eye cancer in adults with a set of highly characteristic genetic alterations. We identified mutations in the BAP1 (BRCA1 Associated Protein 1) gene in uveal melanomas with high likelihood of metastasis and recurrent mutations in the splicing factor SF3B1 with les...

  • Wednesday, 19th, June 2024 - Séminaire Speaker(s) : Martin Schwartz

    Mechanotransduction, homeostasis and disease in the vascular system

    The purpose of the vascular system, pumping blood to the tissues, is fundamentally mechanical.  Cells of vessel walls thus use shear stress from blood flow and wall stress/strain from blood pressure as cues to guide embryonic morphogenesis and adult homeostasis.  I will present our latest unpubli...

  • Wednesday, 26th, June 2024 - Séminaire Speaker(s) : Daniel Robert

    Bees, flowers and electrostatics: a window on a new sensory ecology

    Working together to exchange nutrition for pollination services, bees and flowers interact relying on vision, olfaction, touch, and humidity sensing. We have discovered that bees can also detect and learn about the weak electric field that arises as they approach a flower. This electric field &nd...

  • Wednesday, 3rd, July 2024 - Séminaire Speaker(s) : Cécile Leduc

    Molecular assembly and mechanics of single vimentin intermediate filaments

    Intermediate filaments (IF) are involved in key cellular functions including polarization, migration, and protection against large deformations. These functions are related to their remarkable ability to extend without breaking, a capacity that should be determined by the molecular organization o...

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