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  • Lundi 4 Septembre 2017 - Séminaire Orateur(s) : Max Gottesman MD PhD (Columbia University, New York, USA)

    Coupling and Uncoupling Transcription with Translation

    We show that transcription and translation are physically coupled in E.coli by the NusG protein. The NTD of NusG binds RNAP, whereas its CTD binds ribosomal protein S10. We present a cryo-EM structure showing NusG CTD bound to S10 in an intact 70S ribosome. We find that NusG is required for coupl...

  • Lundi 11 Septembre 2017 - Séminaire Orateur(s) : Shane Crotty (La Jolla Institute for Allergy & Immunology (LJI), La Jolla, CA, USA)

    Assessing the engines of affinity maturation to vaccines: germinal centers and Tfh cells

    T cell help to B cells was one of the earliest discovered functions of T cells, 49 years ago, resulting in the coining of the term ‘helper cell'. Follicular helper T cells (Tfh) are the specialized CD4 T cells for B cell help. Generation of long term humoral immunity is a complex process pr...

  • Mardi 12 Septembre 2017 - Séminaire Orateur(s) : Philippe JAY (Institute of Functional Genomics, Montpellier)

    Tuft cells : intestinal epithelial sentinels linking luminal danger to immune responses

    - Gerbe F., Sidot E., Smyth D. J., Ohmoto M., Matsumoto I., Dardalhon V., Cesses P., Garnier L., Pouzolles M., Brulin B., Bruschi M., Harcus Y., Zimmermann V. S., Taylor N., Maizels R. M. and Jay P. : Intestinal epithelial tuft cells initiate type 2 mucosal responses to helminth parasites. Nature...

  • Jeudi 14 Septembre 2017 - Séminaire Orateur(s) : Patrick Rochette (Centre de Recherche du CHU de Québec – Université Laval, Québec, Canada)

    Ultraviolet A-induced oxidation in the cornea: short and long-term effects

    Human eye is directly exposed to solar ultraviolet (UV) radiations but the retina is protected from those rays. Indeed, the cornea and the lens filter UV rays to protect the retina against their toxicity. The UVA component represents 95% of solar UV radiation and has photo-oxidant properties. How...

  • Mardi 19 Septembre 2017 - Séminaire Orateur(s) : Carolyn J. BROWN (Department of Medical Genetics, University of British Columbia)

    Making two equal one: Human X-chromosome inactivation

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  • Jeudi 19 Octobre 2017 - Séminaire Orateur(s) : Guillaume Lebon (Institut de Génomique Fonctionnelle, Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Montpellier, F-34000 Montpellier (France).)

    Structural characterisation of G protein-coupled receptors, What have we learnt?

    G Protein Coupled receptors (GPCRs) are integral membrane protein and constitute the largest family of membrane proteins. GPCRs are localised at the plasma membrane of eukaryotic cells. They mediate signal transduction from the extracellular to the intracellular compartment and play an important ...

  • Vendredi 24 Novembre 2017 - Séminaire Orateur(s) : Sara Sigismund (IFOM, Fondazione Istituto FIRC di Oncologia Molecolare)

    ER-PM contact sites control EGFR endocytosis and signaling

    The integration of distinct endocytic routes is critical to regulate receptor signaling. A non-clathrin endocytic pathway (NCE) of the epidermal growth factor receptor (EGFR) is activated at high ligand concentrations, in parallel to clathrin-mediated endocytosis (CME). EGFR-NCE requires receptor...

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