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Seminar

Friday, May 3rd, 2024
11h
Centre de recherche - Paris - Amphith√©√Ętre Constant-Burg - 12 rue Lhomond, Paris 5e

Understanding and modeling aging

Aging is associated with a decline in tissue function and the onset of a constellation of diseases. We are interested in understanding aging, with a particular focus on brain aging. Because aging is complex, we use organisms with diverse lifespans – the worm C. elegans, the African killifish, the mouse, and cells from mice and humans. We are interested in identifying epigenetic and metabolic pathways involved in delaying aging in response to external stimuli, including nutrients and the opposite sex. Our lab is also interested in using mouse models to address complex questions about mammalian aging, notably the regulation of regenerative neural stem cells and their progeny during aging. Finally, we are pioneering the naturally short-lived African killifish as a new model to identify principles underlying vertebrate aging and “suspended animation”. We hope that these discoveries will identify new strategies to delay, suspend, or even reverse aspects of aging and age-related diseases.

Speaker(s)

Anne Brunet
Professor of Genetics / Director of Laboratory

Stanford University School of Medicine

Invited by

Nicolas Manel

Institut Curie

Contact

Sylvia Trival

To sum up

Dr. Brunet obtained her B.Sc. from the Ecole Normale Supérieure in Paris and her Ph.D. from the University of Nice, France. She did her postdoctoral training with Dr. Michael Greenberg at Harvard Medical School. Dr. Brunet is interested in the molecular mechanisms of aging and longevity. Dr. Brunet’s laboratory has developed an original line of investigation to understand aging based on the integration of model organisms with diverse lifespans – worms, fish, and mice. Using the worm Caenorhabditis elegans, the Brunet lab has identified pathways involved in delaying aging in response to external stimuli such as availability of nutrients and availability of the opposite sex. She made the exciting discoveries that lifespan extension can be regulated by chromatin modifiers and inherited in a transgenerational epigenetic manner. Her lab also uses mouse models to address complex questions about mammalian aging, notably mechanisms regulating neural stem cell aging. Importantly, the Brunet lab has pioneered the naturally short-lived African killifish as a new model to identify principles underlying aging and ‘suspended animation’. Dr. Brunet has published over 100 peer-reviewed papers and reviews. She has received several awards, including the Pfizer/AFAR Innovation in Aging Research Award and the Vincent Cristofalo “Rising Star” Award in Aging Research. She received a Pioneer Award and a Transformative Award from the NIH Director's fund, which supports scientists who propose pioneering and transforming approaches to major challenges in biomedical research. In 2022, together with Dr. Andrew Dillin, she received the Lurie Prize in Biomedical Sciences.