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Seminar

Friday, 5th, April 2024
From 11h To 12h
Centre de recherche - Paris - Amphithéâtre Hélène Martel-Massignac (BDD)

A garden of forking paths: branching, switching and reversal in meiotic recombination

Abstract

Meiotic recombination involves repair of double strand DNA breaks by homologous recombination to form crossovers and noncrossovers. Current models suggest that different mechanisms form these two products: noncrossovers by synthesis dependent strand annealing; COs by double Holliday junction formation and resolution. In testing these predictions, we found evidence for remarkable dynamism during meiotic DSB repair. This includes switching between repair templates and strand invasion by both DSB ends during both noncrossover and crossover recombination, and extensive branch migration by the Holliday junction intermediates that are CO precursors. I will discuss the mechanistic and regulatory implications of these findings.

Speaker(s)

Dr. Michael Lichten
Scientist Emeritus

National Cancer Institute - Center for Cancer Research

Hosted by

Dr. Valerie Borde
Research Director
Dynamique de l'information génétique : bases fondamentales et cancer (DIG-Cancer) (UMR3244)

Institut Curie

Dr. Iro Triantafyllakou
Project Manager
Dynamique de l'information génétique : bases fondamentales et cancer (DIG-Cancer) (UMR3244)

Institut Curie

Invited by

Dr. Valerie Borde
Research Director
Dynamique de l'information génétique : bases fondamentales et cancer (DIG-Cancer) (UMR3244)

Institut Curie

Contact

Dr. Michael Lichten

Scientist Emeritus

National Cancer Institute - Center for Cancer Research

Dr. Valerie Borde

Research Director

Institut Curie

Send an e-mail

Dr. Iro Triantafyllakou

Project Manager

Institut Curie

Send an e-mail