Cell identities are largely defined by their transcriptomes, which result from precise gene activation and silencing programs. In this context, a major and still unresolved question is how particular genes are targeted for repression in certain cell types while they are expressed in others. Here, I will discuss how classic and emerging model species (Drosophila, mice and crickets) deal with this central issue, highlighting common trends but also divergent features, putting into perspective the conservation of these mechanisms.

Seminar suggested by Céline Vallot