Melanoma metastatic niche formation: extracellular vesicles, miRNA, immune, CAF and more
Melanoma initiate at the epidermis and become metastatic once invade into the dermis. We present mutation independent trigger of melanoma switch into the invasive dermal phenotype from the radial dermal growth. We further showed how melanoma cells shape the tumor microenvironment by the trafficking of miRNA via large extracellular vesicles. In recent work we found melanoma interactions with the skin immune system in a way that blocks thier activity and promote cancer progression.
Weizmann Institute of Science, ISR
Intégrité du génome, ARN et Cancer (UMR3348)