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  • Friday, 21st, June 2024 - Séminaire Speaker(s) : Leonie Young (Department of Surgery, RCSI)

    Aberrant epi-transcriptomic alterations contribute to disease progression in breast cancer brain metastasis

    1.7 million women globally will face a diagnosis of breast cancer, almost 40% of whom will develop metastatic disease. Breast cancer brain metastasis are a frequent and aggressive form of metastatic spread, with treatment options limited for each of the clinically relevant molecular subtypes. Adv...

  • Monday, 24th, June 2024 - Séminaire Speaker(s) : Anne Bernheim

    Self-assembled active actomyosin gels spontaneously curve and wrinkle similar to biological cells and tissues

    Living systems adopt a diversity of curved and highly dynamic shapes. These diverse morphologies appear on many length-scales, from cells to tissues and organismal scales. The common driving force for these dynamic shape changes are contractile stresses generated by myosin motors in the cell cyto...

  • Wednesday, 26th, June 2024 - Séminaire Speaker(s) : Daniel Robert

    Bees, flowers and electrostatics: a window on a new sensory ecology

    Working together to exchange nutrition for pollination services, bees and flowers interact relying on vision, olfaction, touch, and humidity sensing. We have discovered that bees can also detect and learn about the weak electric field that arises as they approach a flower. This electric field &nd...

  • Monday, 1st, July 2024 - Séminaire Speaker(s) : Prof. Keehoon Jung (Department of Anatomy and Cell Biology, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea)

    Tumor-associated monocytes and neutrophils: Targets for immunotherapy?

     Our goal is to better understand the immune microenvironment in cancers using advanced methodologies, including in vivo imaging and single-cell genomics. In particular, we aim to unveil the immense potential of myeloid populations in cancers, an emerging field. Real-time intravital multi-photon ...

  • Wednesday, 3rd, July 2024 - Séminaire Speaker(s) : Cécile Leduc

    Molecular assembly and mechanics of single vimentin intermediate filaments

    Intermediate filaments (IF) are involved in key cellular functions including polarization, migration, and protection against large deformations. These functions are related to their remarkable ability to extend without breaking, a capacity that should be determined by the molecular organization o...

  • Wednesday, 3rd, July 2024 - Séminaire Speaker(s) : Merlin LANGE (Chan Zuckerberg Biohub, San Francisco)

    Building a Multimodal Atlas of Vertebrate Development

    Elucidating the developmental processes of organisms requires a comprehensive understanding of cell lineages across spatial, temporal, and molecular dimensions. Advances in imaging and omics technologies allow us to generate technically challenging multidimensional datasets that capture developme...

  • Wednesday, 10th, July 2024 - Séminaire Speaker(s) : Robert E. Campbell

    Engineering fluorescent biosensors to spy on cell signaling and metabolism

    The ever-broadening selection of high performance fluorescent protein (FP)-based biosensors is revolutionizing our ability to spy on the otherwise invisible world of intracellular signalling and metabolism. In this seminar I will describe our most recent efforts to use protein engineering to make...

  • Wednesday, 17th, July 2024 - Séminaire Speaker(s) : Jianping FU

    Bioengineering Human Embryo and Organ Models

    Early human development remains mysterious and difficult to study.  Recent advances in developmental biology, stem cell biology and bioengineering have contributed to a significant interest in constructing controllable, stem cell-based models of human embryo and organs (embryoids / organoids).  T...

  • Monday, 7th, October 2024 - Séminaire Speaker(s) : Luca Magnani (Institute of Cancer Research)

    Breast Cancer Dormancy: A Link to the Past

    Luca Magnani graduated from his bachelor's and master's degree at the University of Bologna. During an exchange visit to Purdue University, he discovered his interest in early embryogenesis. Dr. Magnani's work took him to Michigan State University, where he continued his research on mouse embryog...

  • Tuesday, 15th, October 2024 - Séminaire Speaker(s) : Sara Lucia Giustina Sigismund

    Endocytic control of cell plasticity in cancer

    Over the past two decades, there has been a significant shift in our understanding of the role of endocytosis and trafficking of signaling receptors. It has evolved from being viewed simply as a signal extinguisher (resulting in long-term attenuation) to being recognized as a sophisticated mechan...

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