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  • Mercredi 20 Février 2019 - Séminaire Orateur(s) : Volker Bormuth (Laboratoire Jean Perrin ( UMR 8237 ) Sorbonne Université)

    A Miniaturized Light-Sheet Microscopy for Whole-Brain Calcium Imaging during Physiological Vestibular Stimulation in Larval Zebrafish

    The vestibular apparatus provides animals with postural and movement-related information that is essential to adequately execute numerous sensorimotor tasks. In order to activate this sensory system in a physiological manner, one needs to macroscopically rotate or translate the animal's head, whi...

  • Jeudi 21 Février 2019 - Séminaire Orateur(s) : Masaru Ishii (Department of Immunology and Cell Biology, Graduate School of Medicine, Osaka University, Osaka, Japan)

    Dynamics of immune cell migration and interaction visualized by intravital microscopy

    During the last decade, intravital optical microscopy has launched a new trend in the field of biology. By using this advanced imaging technique we have established a new system for visualizing in situ behavior of a diversity of living cells within intact tissues and organs. Among them, we succee...

  • Lundi 25 Février 2019 - Séminaire Orateur(s) : Alan D. D’Andrea

    PARP Inhibitor Resistance and Acquired Vulnerability

    Large-scale genomic studies have demonstrated that approximately 50% of high-grade serous ovarian cancers (HGSOCs) harbor genetic and epigenetic alterations in homologous recombination repair (HRR) pathway genes. The most commonly altered HRR genes are BRCA1 and BRCA2, followed by other Fanconi A...

  • Mercredi 27 Février 2019 - Séminaire Orateur(s) : Charles Kervrann (Serpico Team / Inria - CNRS - Institut Curie - UPMC)

    Computational methods for fluorescence microscopy and cryo-electron tomography

    Computational methods for fluorescence microscopy and cryo-electron tomography Charles Kervrann Serpico Team / Inria - CNRS - Institut Curie - UPMC During the past two decades, biological imaging has undergone a revolution in the development of new light and electron microscopy techniques that al...

  • Lundi 4 Mars 2019 - Séminaire Orateur(s) : Sara Richter (Dept Molecular Medicine University of Padua, Italy)

    Presence, function and targeting of G-quadruplexes in the human immunodeficiency virus-1 (HIV-1)

    Presence, function and targeting of G-quadruplexes in the human immunodeficiency virus-1 (HIV-1)

  • Vendredi 8 Mars 2019 - Séminaire Orateur(s) : Amir Bitran (Harvard University - Biophysics)

    Amir Bitran : Rare codons coordinate co-translational protein folding to avoid misfolded intermediates

    In the cell, many proteins begin folding co-translationally. To ensure proper function, co-translational folding must allow proteins to rapidly reach their native state while avoiding potentially harmful misfolded intermediates. Here we provide evidence that this process may be regulated in vivo ...

  • Lundi 11 Mars 2019 - Séminaire Orateur(s) : Jef Boeke (Institute for Systems Genetics, NYU Langone Health)

    Engineering genomes, karyotypes, and the dark matter of the human genome

    Rapid advances in DNA synthesis techniques have made it possible to engineer diverse genomic elements, pathways, and whole genomes, providing new insights into design and analysis of systems. The synthetic yeast genome project, Sc2.0 is well on its way with seven synthetic Saccharomyces cerevisia...

  • Lundi 11 Mars 2019 - Séminaire Orateur(s) : Carlos Salomon (Head of the Exosomes Biology Laboratory, University of Queensland Centre for Clinical Research, Brisbane - Australia)

    Extracellular vesicles in Obstetrics and Gynaecology: Focus on pregnancy complications and ovarian cancer

    I am a group leader and senior Lions Medical Research Foundation (LMRF) Fellow working at the University of Queensland Centre for Clinical Research (UQCCR). I am recognized as a national and international researcher working in the field of extracellular vesicles focusing on the reproductive biolo...

  • Mercredi 13 Mars 2019 - Séminaire Orateur(s) : Hans-Guido WENDEL (Memorial Sloan-Kettering Cancer Center – New York)

    Exploring mRNA translation as a target in cancer

    I will discuss recent insights into new therapeutic targets in cancer with an emphasis on lymphoma/leukemia. These will include mRNA translation, immune-receptors and unpublished data from genetic CRISPR/CAS9 screens for new and druggable mechanisms

  • Lundi 1 Avril 2019 - Séminaire Orateur(s) : Linda Partridge

    Domain 2 Seminar - Linda Partridge

    Title & abstract to come.

  • Jeudi 18 Avril 2019 - Séminaire Orateur(s) : Molly Przeworski

    An evolutionary perspective on meiotic recombination in vertebrates

    Meiotic recombination is a fundamental genetic process that generates new combinations of alleles on which natural selection can act and ensures the proper alignment and segregation of chromosomes. Recombination events are initiated by double strand breaks deliberately inflicted on the genome dur...

  • Lundi 29 Avril 2019 - Séminaire Orateur(s) : David Tremethick (the John Curtin School of Medical Research, Austrialian National University)

    Histone variants: linking chromatin structure with gene expression

    It has been more than a decade since the human genome was completely sequenced but how this genomic information is selectively utilized to direct spatial and temporal gene expression patterns still remains to be elucidated. Ultimately linked to the establishment of a unique gene expre...

  • Jeudi 9 Mai 2019 - Séminaire

    Domain 2 Meeting

    Agenda to come.

  • Jeudi 20 Juin 2019 - Séminaire Orateur(s) : Trey IDEKER (UC San Diego School of Medicine)

    Decoding tumor genomes through the hierarchical pathway architecture of the cancer cell

    Although cancer is governed by complex molecular systems, the composition and modular organization of these systems remains poorly understood. I will describe efforts by the Cancer Cell Map Initiative (CCMI) to generate large protein interaction maps of tumor cells, which we are integrating with ...

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