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  • Tuesday, 2nd, March 2021 - Webinaire Speaker(s) : Reini F. LUCO (Chromatin and Splicing team, Institute of Human Genetics, Montpellier, FRANCE)

    More than just a crosstalk, histone marks can be drivers of the changes in splicing observed during the epithelial-to-mesenchymal transition

    Histone marks have long been suggested to play a role in the regulation of alternative splicing. From such studies, the impact of chromatin in splicing seemed limited, affecting just a small number of exons, and in a modulatory way by just fine-tuning the final splicing outcome. By combining geno...

  • Wednesday, 3rd, March 2021 - Webinaire Speaker(s) : Rubén Fernandez-Busnadiego (Institute of Neuropathology, University Medical Center Goettingen)

    Unravelling the structure of toxic protein aggregates in situ

    Protein aggregation is a hallmark of many neurodegenerative diseases, including Huntington's, Parkinson's and amyotrophic lateral sclerosis. However, the mechanisms linking aggregation to neurotoxicity remain poorly understood, partly because only limited information is available on the native st...

  • Wednesday, 17th, March 2021 - Webinaire Speaker(s) : Romain Levayer (Institut Pasteur)

    Fine tuning of cell death during epithelial homeostasis: from local coordination to death commitment and cell extrusion

    While the signals regulating apoptosis during development are rather well known, what regulates the precise spatio-temporal distribution of cell death and the adjustment of cell elimination to local perturbations is not well understood. Similarly, how cells eventually engage in apoptosis and how ...

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