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  • Mardi 27 Juin 2017 - Séminaire Nuclear dynamic series Orateur(s) : Alfonso Fernandez ALVAREZ (NIH/NCI, Bethesda (MD, USA))

    Centromeric control of nuclear envelope disassembly

    Chromosome ‘linearity' is so universal among eukaryotes that we assume it to be evolutionarily advantageous. Nonetheless, formidable challenges are presented by linear chromosome ends, as their resemblance to damage-induced DNA breaks makes them vulnerable to degradation and end-joining pat...

  • Mardi 4 Juillet 2017 - Séminaire Nuclear dynamic series Orateur(s) : Yamini DALAL (NIH/NCI, Bethesda (MD, USA))

    Twisting the dragon's tail: histone variant dynamics in human tumors

    Dr. Dalal's lab focuses on proteins called histones, which package the entirety of the human genome into a nucleoprotein complex called chromatin in vivo. Specific regions of chromatin are prone to fragility and chromosomal rearrangements in cancer cells. Consequently, understanding how this prot...

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