The reduced-dimensionality mechanism of homology search by RecA filament during double stranded break repair

Homologous recombination is essential for the accurate repair of double-stranded DNA breaks (DSBs). Initially, the RecBCD complex resects the ends of the DSB into 3′ single-stranded DNA on which a RecA filament assembles. Next, the filament locates the homologous repair template on the sist...