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Centromeric control of nuclear envelope disassemblyChromosome ‘linearity' is so universal among eukaryotes that we assume it to be evolutionarily advantageous. Nonetheless, formidable challenges are presented by linear chromosome ends, as their resemblance to damage-induced DNA breaks makes them vulnerable to degradation and end-joining pat... |
Twisting the dragon's tail: histone variant dynamics in human tumorsDr. Dalal's lab focuses on proteins called histones, which package the entirety of the human genome into a nucleoprotein complex called chromatin in vivo. Specific regions of chromatin are prone to fragility and chromosomal rearrangements in cancer cells. Consequently, understanding how this prot... |