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  • Mercredi 27 Septembre 2017 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Hans Clevers (Hubrecht Institute, Utrecht, the Netherlands)

    Stem cell-grown organoids as models for human disease

    The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. We originally defined Lgr5 as a Wnt target gene, transcribed in colon cancer cells. Two knock-in alleles revealed exclusive expression of Lgr5 in cycling, columnar cells at the crypt base. Using lineage tracing e...

  • Lundi 9 Octobre 2017 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Jürgen Knoblich (Institute of Molecular Biotechnology (IMBA), Vienna, Austria)

    Neural stem cells and brain development: From Drosophila to humans

    The human brain is the most fascinating and most complex organ of all. Despite this enormous complexity, the billions of neurons in our brain arise from a limited number of progenitors following a specific set of lineage decisions. We combine Drosophila genetics with 3D organoid cultures derived ...

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