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Friday, 17th, December 2021
Centre de recherche - Paris - Amphithéâtre Marie Curie

Applied Cybergenetics

Gene expression plays a central role in the orchestration of cellular processes. We recently developed an experimental platform for real-time, closed-loop control of gene expression that integrates microscopy for monitoring gene expression in live cells, microfluidics to manipulate the cells environment, and dedicated software for automated imaging, quantification and model predictive control strategy. This method, called Cybergenetics, implements a dynamic, closed-loop interaction between cells and a computer, making it possible to control precisely the level of expression of a gene for both time-constant and time varying target profiles, at the population level, and at the single-cell level. I will discuss recent developments of Cybergenetics and dynamic control of yeast and bacteria.


Dr. Pascal HERSEN
physicist, senior group leader and director of the Physico Chimie Curie laboratory (UMR168, Institut Curie, PSL, CNRS, Sorbonne Université)
Physico-chimie Curie (UMR168)

Institut Curie

Invited by

Dr. Chunlong Chen
Group leader
Dynamique de l'information génétique : bases fondamentales et cancer (DIG-Cancer) (UMR3244)

Institut Curie

To sum up

Pascal Hersen (CNRS, Institut Curie) is a physicist, senior group leader and director of the Physico Chimie Curie laboratory  (UMR168, Institut Curie, PSL, CNRS, Sorbonne Université). He studied theoretical and nonlinear physics at ENS Lyon and did a PhD on the shape and song of sand dunes at ENS Paris. He then switched to biology, joining the Bauer Center for Genomic Research at Harvard University as a postdoc. Since then he has been interested at various problems at the interface between physics and biology with a focus on Mechanobiology, synthetic biology and microfluidics applied to biology. His team develops tools in microscopy, microfabrication and synthetic biology to study the physics of living cells and specifically how information flows in cellular processes.  He is a pioneer in the field of Cybergenetics, a field of research at the interface of control theory and synthetic biology which aims at taking control of cellular processes thanks to external feedback control loop, interfacing living systems with computers and machines