> Back to seminars list

Seminar

Wednesday, 30th, June 2021
From 11h To 12h30
Centre de recherche - Paris - Webinar

Systems biology of coupled oscillators in mammalian cells

Most organisms have evolved a circadian timing system to adapt their physiology and behavior to the daily environmental changes resulting from the rotation of the earth on its axis. This is achieved through a self-sustained oscillatory gene network present in virtually all cells and which temporally coordinates a plethora of molecular, cellular and physiological processes. Interestingly, daily synchronous rhythms of the cell division cycle are observed in many species including humans. This strongly suggests a connection between the circadian clock and the cell cycle machineries. Consistently, our team and others have uncovered molecular mechanisms underlying such crosstalk. However, despite this mechanistic knowledge, how the clock and cell cycle dynamics are temporally coordinated have remained elusive. By combining single live cell imaging and mathematical modelling, we could show that in unsynchronized cells, the cell cycle and circadian clock robustly phase-lock each other in a 1:1 fashion so that in an expanding cell population the two oscillators oscillate in a synchronized way with a common frequency. Further investigation using different mathematical modelling frameworks also suggests that the nuclear receptor REV-ERBα may be an important node in the coupled cell-cycle-clock system. Exploring the temporal coordination of cell division by phase-locking to the clock at a single cell level has significant implications because circadian disruption is increasingly being linked to malignant cell proliferation.

Speaker(s)

Prof. Franck DELAUNAY
professor of animal physiology at the University of Nice Côte d'Azur (France) and team leader at the Valrose Institute of Biology (UCA/CNRS/INSERM)

Hosted by

Dr. Emmanuel BARILLOT
U900 SYSBIO Team Leader
Domain 3 - U900 - CBIO - Bioinformatics, Biostatistics Epidemiology and Computational Systems

Institut Curie

Invited by

Dr. Laurence CALZONE
U900 SYSBIO Team Senior Scientist
Domain 3 - U900 - CBIO - Bioinformatics, Biostatistics Epidemiology and Computational Systems

Institut Curie

Contact

Dr. Laurence CALZONE

U900 SYSBIO Team Senior Scientist

Institut Curie

Send an e-mail