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Seminar

Tuesday, October 15th, 2019
11h30
Centre de Recherche - Orsay - Amphithéâtre du Bâtiment 111

Deciphering novel functions for histone deacetylases in genome maintenance and designing mechanism based therapeutic strategies for cancers

     Histone deacetylases (HDACs) are classically connected to transcriptional regulation. However, we previously showed unrecognized functions for mammalian class 1 HDACs (HDACs 1, 2 and 3) in DNA replication, DNA repair and DNA damage response. HDACs are attractive and proven therapeutic targets in cancer therapy as exemplified by the availability of FDA-approved HDIs. However, an FDA-approved HDI is currently not available for treating B-cell malignancies. My lab is focused on understanding functions for individual HDACs in genome stability and applying these mechanistic studies to design novel epigenetic based therapeutic strategies for a subset of hard-to-treat cancers.
 

Speaker(s)

Srividya Bhaksara

Invited by

Marie Dutreix
Domain 1 - UMR 3347 / U1021 - Normal and pathological signaling

Institut Curie

Contact

Marie Dutreix

Institut Curie

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