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Seminar

Friday, October 11th, 2019
11h
Centre de Recherche - Paris - Amphith√©√Ętre Antoine Lacassagne

Contributions of mitochondrial bioenergetic functions to innate immunity

Metabolic reprogramming has recently emerged as a major feature of innate immune cells. At the core of immune cell metabolic reprogramming is the mitochondrion, a bioenergetic organelle that also serves as an immune signaling platform. Our work thus aims at unraveling the structural and functional adaptations of the mitochondrial respiratory chain and metabolism and their relevance for innate immune cells mediated antibacterial immunity. We specifically assess the connection between innate immune receptors engagement by microbial products and the electron transport chain regulation. In turn, we evaluate the innate immune consequences of cellular metabolism dysfunctions and mitochondrial respiratory chain disorders.

Publications:

Garaude J.*,$, Acín-Pérez R.*, Martínez-Cano S.,Enamorado M., Ugolini M., Nistal-Villán E., Hervás-Stubbs S, Pelegrín P., Sander L.E., Enríquez J.A.$, Sancho D.$. Mitochondrial respiratory-chain adaptions in macrophages contribute to antibacterial host defence. Nature Immunology, 2016. doi: 10.1038/ni.3509.

Garaude J. Reprogramming of mitochondrial metabolism by innate immunity. Current Opinion in Immunology, 2018. doi: 10.1016/j.coi.2018.09.010

Sander L.E. and Garaude J., The mitochondrial respiratory chain: a metabolic rheostat of antibacterial immunity. Mitochondrion, 2017 Oct 17. pii: S1567-7249(17)30224-6

Speaker(s)

Johan Garaude

Institute for Regenerative Medicine & Biotherapy (IRMB), Montpellier

Invited by

Nicolas Manel
Domain 3 - U932 - Immunity and Cancer

Institut Curie

Philippe Benaroch
Domain 3 - U932 - Immunity and Cancer

Institut Curie

Contact

Nicolas Manel

Institut Curie

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Philippe Benaroch

Institut Curie

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