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Seminar

Wednesday, 18th, September 2019
From 11h30 To 12h30
Centre de Recherche - Paris - Amphith√©√Ętre Marie Curie

Statistical physics and mesoscopic modeling to interpret experiments on DNA

Tethered particle motion (TPM) experiments are single-molecule techniques enabling one to address in vitro the molecular properties of DNA and its interactions with the solvent and various partners, e.g. involved in genetic regulations. These techniques provide raw data such as the tracked particle amplitude of movement, from which relevant information about DNA conformations or states must be recovered. Solving this inverse problem appeals to specific theoretical tools together with the data pre-processing procedures that ought to be implemented to avoid biases inherent to these experimental techniques.

Tethered particle motion (TPM) experiments are single-molecule techniques enabling one to address in vitro the molecular properties of DNA and its interactions with the solvent and various partners, e.g. involved in genetic regulations. These techniques provide raw data such as the tracked particle amplitude of movement, from which relevant information about DNA conformations or states must be recovered. Solving this inverse problem appeals to specific theoretical tools together with the data pre-processing procedures that ought to be implemented to avoid biases inherent to these experimental techniques.

 

Speaker(s)

Nicolas Destainville

LPT Toulouse

Invited by

Jean-Patrick Vrel