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Seminar

Wednesday, March 13th, 2019
18h
Centre de Recherche - Paris - Amphithéâtre Constant-Burg - 12 rue Lhomond, Paris 5e

Mechanics, topology and geometry of mammalian chromosomes and nuclei and their modulation by histone epigenetic marks

Our lab uses biophysical methods, with particular emphasis on micromanipulation of single DNA molecules and single chromosomes, to study the internal structure of chromosomes in vivo, and to study chromosome-organizing proteins and DNA topoisomerases in vitro. We also develop mathematical models relevant to these types of experiments. Projects in progress involve combining fluorescence microscopy and force microscopy in experiments on DNA-protein complexes and whole chromosomes, and in-vivo studies of coupling of chromosome dynamics to gene expression.

Speaker(s)

Prof. John Marko
Prof.

Department of Molecular Biosciences, Northwestern University, Evanston, USA

Hosted by

Unit Training

Invited by

Geneviève Almouzni
Domain 2 - UMR 3664 - Nuclear Dynamics

Institut Curie

Nathalie Dostatni
Domain 2 - UMR 3664 - Nuclear Dynamics

Institut Curie

Contact

Geneviève Almouzni

Institut Curie

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Unit Training

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Nathalie Dostatni

Institut Curie

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Elodie Mieville

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