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Friday, 15th, February 2019
Centre de Recherche - Paris - Amphith√©√Ętre Marie Curie

Chromatin based control of germ cell and early embryonic development in mice

In mammals, fusion of two highly differentiated gametes gives rise to a totipotent zygote capable of developing into a whole organism. The switch in cell fate coincides with translation and degradation of maternally provided transcripts, initiation of global transcription and “epigenetic reprogramming” of germline chromatin states into an embryonic state. Changes in chromatin are dynamic and occur in part in a parent-of-origin specific manner. I will discuss our ongoing efforts to unravel the role of Polycomb group proteins in epigenetic inheritance between generations, and in modulating chromatin states and transcription in pre-and post-implantation embryos. I will also discuss our evolutionary and functional insights in histone biology during spermatogenesis.


Prof. Antoine Peters
Senior Group Leader, Friedrich Miescher Institute for Biomedical Research, Basel

Friedrich Miescher Institute for Biomedical Research (FMI)

Hosted by

Shauna Katz

Invited by

Genevieve Almouzni