Ligands for the immune activating receptor NKG2D: different features affecting NK cell response
Natural Killer (NK) cells play a key role in tumor control, and recognition by the activating receptor NKG2D of its ligands is particularly important for this activity, since although absent on healthy cells, NKG2D ligands (NKG2D-L) are expressed by stressed cells in different pathological situations. NKG2D-L can also be shed to the extracellular milieu in exosomes or as soluble proteins, leading to reduced cytotoxic activity. Therefore, the role of NKG2D and its ligands in anti-tumor control depends on many factors. In this seminar, different aspects of NKG2D-L biology will be addressed: at a molecular level, the specific biochemical characteristics and the GPI anchoring of the NKG2D-L, MICA, affecting its release in exosomes; at a cellular level, exploring the communication mediated by the transfer of intact NKG2D-L from the target cell to the NK cell and how this acquisition affect NK function; and finally, in a model of metastatic melanoma cells, the effects of chemotherapeutic agents on NKG2D-L expression, reducing NK cell recognition, and how it can be reversed with drug combinations. These data together, increase our understanding of NKG2D-L biology and show the complexity of the NKG2D system.
PhD in Molecular Biosciences
Autónoma University, Madrid, Spain
Chef d'équipe Integrative biology of human dendritic cells and T cell
Seminar suggested by U932