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Vendredi 2 Mars 2018
Centre de Recherche - Paris - Amphithéâtre Marie Curie

Design, synthesis and biological evaluation of carbohydrate derivatives as potential antitumor and antiviral agents

Glycosphingolipids (GSLs) are components of all animal cell membranes and are involved in many cellular functions including proliferation, adhesion, motility, and differentiation. Ganglioside GM3 (NeuAcα3Galβ4Glcβ1Cer), the first and simplest member in the metabolic series of a GSLs family containing sialic acids (N-acetyl- and N-glycolyl-neuraminic acids and their O-acyl derivatives), is known as one of the most abundant tumor-associated carbohydrate antigens on several types of tumors. Glycosphingolipid structures, and their changes associated with biological functions, have been the central focus of our studies, since structural change is the starting point for understanding biological significance, and enzymatic/genetic mechanisms.

The seminar will be dedicated to this important glycosphingolipid, focusing on modern glycochemistry methods. Some cyclodextrin based conjugates will also be presented for their potential biological application.



Dr Yongmin ZHANG

Université Pierre et Marie Curie-Paris 6

Invité(e)(s) par

Dr Chunlong CHEN
Domain 2 - UMR 3244 - Dynamics of genetic Information

Institut Curie

En bref


Dr. Yongmin Zhang graduated from the School of Pharmaceutical Sciences of Beijing Medical University (current Peking University Health Science Centre) in 1982. He got his Ph.D. of Medicinal Chemistry at University of Paris 11 in 1986. After two years post-doctoral research at Beijing Medical University, he worked as visiting associate professor then visiting professor at University of Paris 11 prior to taking a permanent position at CNRS (French National Scientific Research Centre) in 1991, where he is now first class research director (DR1) at the CNRS-University of Paris 6 (Pierre & Marie Curie University) joint research laboratory. He is laureate of several research awards, such as “Prize of medicinal chemistry research” which he got from the 25th International Conference on Medicinal Chemistry. He worked as visiting scholar at University of Washington in United States during 1995-1997. He was elected member of French National Academy of Pharmacy in 2012. Inventor of 4 patents, Dr. Yongmin Zhang has published more than 200 original research papers. His current research interests include biologically active oligosaccharides, glycosphingolipids, carbasugars, azasugars, modified cyclodextrins, and fullerene chemistry, aiming at the carbohydrate based drug development.