Design, synthesis and biological evaluation of carbohydrate derivatives as potential antitumor and antiviral agents
Glycosphingolipids (GSLs) are components of all animal cell membranes and are involved in many cellular functions including proliferation, adhesion, motility, and differentiation. Ganglioside GM3 (NeuAcα3Galβ4Glcβ1Cer), the first and simplest member in the metabolic series of a GSLs family containing sialic acids (N-acetyl- and N-glycolyl-neuraminic acids and their O-acyl derivatives), is known as one of the most abundant tumor-associated carbohydrate antigens on several types of tumors. Glycosphingolipid structures, and their changes associated with biological functions, have been the central focus of our studies, since structural change is the starting point for understanding biological significance, and enzymatic/genetic mechanisms.
The seminar will be dedicated to this important glycosphingolipid, focusing on modern glycochemistry methods. Some cyclodextrin based conjugates will also be presented for their potential biological application.
CNRS UMR 8232
Université Pierre et Marie Curie-Paris 6
Domain 2 - UMR 3244 - Dynamics of genetic Information