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Vendredi 2 Février 2018
Centre de Recherche - Paris - Amphithéâtre Marie Curie

DNA replication stress and cancer

DNA replication stress is prevalent in human cancer. I will describe our latest efforts to understand how oncogenes induce DNA replication stress in cancer and how the presence of DNA replication stress in cancers could lead to therapeutic opportunities.


Pr Thanos Halazonetis

Department of Molecular Biology, University of Geneva, Switzerland

Invité(e)(s) par

Arturo Londono
Directeur de Recherche CNRS
Domain 2 - UMR 3244 - Dynamics of genetic Information

Institut Curie

Pr Professor Madalena Tarsounas (Mayent-Rothschild)

Genome Stability and Tumourigenesis Group, Department of Oncology, University of Oxford, Oxford, OX3 7DQ, U.K.


Arturo Londono

Directeur de Recherche CNRS

Institut Curie

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En savoir plus

1. S. K. Sotiriou, I. Kamileri, N. Lugli, K. Evangelou, C. Da−Re, F. Huber, L. Padayachy, S. Tardy, N. L. Nicati, S. Barriot, F. Ochs, C. Lukas, J. Lukas, V. G. Gorgoulis, L. Scapozza, and T. D. Halazonetis. (2016). Mammalian RAD52 functions in break−induced replication repair of collapsed DNA replication forks. Molecular Cell 64, 1127−1134.


2. N. Lugli, V. S. Dionellis, P. Ordonez−Moran, I. Kamileri, S. K. Sotiriou, J. Huelsken, and T. D. Halazonetis. (2017). Enhanced rate of acquisition of point mutations in mouse intestinal adenomas compared to normal tissue. Cell Reports 19, 2185-2192.


3. M. Macheret, and T. D. Halazonetis. (2017). Firing of ectopic origins upon shortening of the G1 phase of the cell cycle underlies oncogene−induced DNA replication stress. Under review.