Single-molecule views of transcription and chromosome organisation in living bacteria
Dr. Kapanidis research group in Oxford uses ultrasensitive microscopy to study biological machinery involved in gene expression (the path from genes on DNA to functional proteins) and its regulation. They study machines of gene expression by observing single biomachines in real time, "in vitro" and in living cells. They main tool is single-molecule fluorescence spectroscopy, a technique that can measure nanometre distances and study molecular interactions in real time (as "molecular movies"). Their work is multidisciplinary, combining diverse disciplines such as optics, spectroscopy, biochemistry, molecular biology, computation, molecular modelling, and signal processing.
Clarendon Laboratory, Dept of Physics, Oxford, UK