Ferroptosis: a regulated cell death nexus linking metabolism, redox biology and disease
Abstract: Dr. Stockwell will describe the discovery of ferroptosis, a form of regulated cell death characterized by the iron-dependent accumulation of lethal lipid hydroperoxides. Current data suggest that ferroptosis is an ancient vulnerability caused by the evolution of cells with polyunsaturated fatty acids in membranes, and that cells have developed complex systems that exploit and defend against this vulnerability. The sensitivity to ferroptosis is dependent on amino acid, iron and polyunsaturated fatty acid metabolism, and the biosynthesis of glutathione, phospholipids, NADPH and coenzyme Q10. Ferroptosis is implicated in the pathological cell death associated with degenerative diseases (e.g. Huntington’s Disease), intracerebral hemorrhage, traumatic brain injury, ischemia-reperfusion injury, and kidney degeneration and may be harnessed for cancer therapy. Mechanisms and therapeutic applications will be described.
Departments of Biological Sciences and Chemistry, Columbia University
Domain 4 - UMR 3666 / U1143 - Chemical Biology of Membranes and Therapeutic Delivery