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Thursday, October 19th, 2017
Centre de Recherche - Paris - Amphithéâtre Antoine Lacassagne

Structural rearrangements in yeast genomes : evolutionary and functional implications

Structural variation is prevalent in natural populations and has broad implications in genome instability, speciation, functional innovation, and disease susceptibility. However, our understanding of its evolutionary dynamics and phenotypic impacts is still limited. Here, we used the yeast S. cerevisiae to examine the role of structural variation in genomic and functional evolution. First, we applied long-read sequencing technology to generate a population-level end-to-end reference panel for both S. cerevisiae and its sister species, S. paradoxus. Structural genome dynamics across the different chromosomal domains (chromosomal cores, subtelomeres and chromosome-ends) is linked to their respective life histories. Currently, we are working on several follow-up projects targeting the implications of these structural rearrangements in S. cerevisiae's domestication and meiotic recombination. The scientific findings of these studies and the associated computational method development will be presented.


Dr. Jia-Xing Yue
CNRS UMR 7284 - INSERM U 1081 - Université Côte d’Azur

Institute for Research on Cancer and Aging, Nice (IRCAN)

Invited by

Dr. Alain Nicolas
Directeur de recherche CNRS
Domain 2 - UMR 3244 - Dynamics of genetic Information

Institut Curie


Dr. Alain Nicolas

Directeur de recherche CNRS

Institut Curie

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