Structural rearrangements in yeast genomes : evolutionary and functional implications
Structural variation is prevalent in natural populations and has broad implications in genome instability, speciation, functional innovation, and disease susceptibility. However, our understanding of its evolutionary dynamics and phenotypic impacts is still limited. Here, we used the yeast S. cerevisiae to examine the role of structural variation in genomic and functional evolution. First, we applied long-read sequencing technology to generate a population-level end-to-end reference panel for both S. cerevisiae and its sister species, S. paradoxus. Structural genome dynamics across the different chromosomal domains (chromosomal cores, subtelomeres and chromosome-ends) is linked to their respective life histories. Currently, we are working on several follow-up projects targeting the implications of these structural rearrangements in S. cerevisiae's domestication and meiotic recombination. The scientific findings of these studies and the associated computational method development will be presented.
CNRS UMR 7284 - INSERM U 1081 - Université Côte dAzur
Institute for Research on Cancer and Aging, Nice (IRCAN)
Directeur de recherche CNRS
Domain 2 - UMR 3244 - Dynamics of genetic Information