Journey to the Center of the Cell
How cells receive and interpret signals from the outside world is a key question in biology. Most signalling is thought to occur through cell surface receptors that transduce signals across the cell membrane and connect to cytosolic signalling cascades. At variance with this model, cell surface receptors are sometimes observed to translocate into the nucleus of cells. The mechanism for this translocation phenomenon is poorly understood. We found that a bacterial toxin, Pseudomonas Exotoxin also traffics to the nucleus. It accumulates in endosomes that associate with the nuclear envelope of cells, the Nuclear Associated Endosomes (NAE). These endosomes then fuse with the nuclear envelope, eventually leading to material translocation into the nucleoplasm of cells. We found that cell surface receptors such as EGFR and LRP1 traffic to the nucleus by the NAE, which may form the core axis of a novel type of signalling pathways.
IMCB - A*STAR in Singapore
Domain 4 - UMR 144 - Subcellular Structure and Cellular Dynamics