Cellular and environmental mechanisms regulating protein absorption in the vertebrate gut
Intestinal epithelial cells (IECs) are highly polarized and can perform vectorial transport of nutrients using asymmetrically localized membrane proteins and via polarized endocytic and trafficking processes. Using cell biological, forward and reverse genetics, and physiology approaches, we have been investigating mechanisms regulating cell polarization and protein absorption in zebrafish and mice. I will share recent results revealing posttranscriptional mechanisms regulating apical polarization and ongoing studies on how the interaction between diet, microbes, and lysosome rich enterocytes regulates protein absorption.
Professor of Cell Biology, Duke University Medical Center
Génétique et biologie du développement (UMR3215 / U934)