Understanding immune aging in mice and humans
Dr. Artyomov will present his work in immune aging where his laboratory using characterized immune aging in mouse tissues identifying GZMK+ CD8 T cells as uniform hallmark of aging. In parallel effort profiling of human circulating immune cells revealed existence of dedicated GZMK+ CD8 effector memory T cells in the peripheral blood that accumulate with age. We will discuss their transcriptional regulation and potential biological implications.
Associate Professor of Pathology and Immunology
Washington University School of Medicine