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Séminaire

Vendredi 23 Septembre 2022
11h30
Centre de recherche - Paris - Amphithéâtre Marie Curie

How Large Cells Do It? Division Positioning in Early Embryos

Life for all animals starts with the fertilization of the egg, followed by the centration of the sperm nucleus and a 3D-choreography of reductive cell divisions called cleavage patterns. These invariant morphogenetic processes rely on the precise motion, positioning and orientation of microtubule asters and spindles that specify division planes. However, the unusually large size of zygotes and early blastomeres raise fundamental questions for division positioning in early embryos. Notably, in these large cells, mechanisms of force generation for aster and spindle positioning are more centered on the material properties and fluid mechanics of bulk cytoplasm. Using a combination of mathematical models, in situ force measurement and quantitative imaging in marine embryos, I will present recent data exploring how elements in the cytoplasm contribute to organize division positioning and embryo morphogenesis.

Orateur(s)

M. MINC Nicolas
Directeur de Recherche

Jacques Monod

Organisateur(s)

M. Alexandre BAFFET
Directeur de recherche
Biologie cellulaire et Cancer (UMR144)

Institut Curie

Invité(e)(s) par

Mme Renata BASTO
Directrice de Recherche
Biologie cellulaire et Cancer (UMR144)

Institut Curie

Veronique MARTHIENS
Chercheur
Biologie cellulaire et Cancer (UMR144)

Institut Curie

Contact

Mme Charlotte LOZACH

Administratrice

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