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Friday, 23rd, September 2022
Centre de recherche - Paris - Amphith√©√Ętre Marie Curie

How Large Cells Do It? Division Positioning in Early Embryos

Life for all animals starts with the fertilization of the egg, followed by the centration of the sperm nucleus and a 3D-choreography of reductive cell divisions called cleavage patterns. These invariant morphogenetic processes rely on the precise motion, positioning and orientation of microtubule asters and spindles that specify division planes. However, the unusually large size of zygotes and early blastomeres raise fundamental questions for division positioning in early embryos. Notably, in these large cells, mechanisms of force generation for aster and spindle positioning are more centered on the material properties and fluid mechanics of bulk cytoplasm. Using a combination of mathematical models, in situ force measurement and quantitative imaging in marine embryos, I will present recent data exploring how elements in the cytoplasm contribute to organize division positioning and embryo morphogenesis.


M. MINC Nicolas
Directeur de Recherche

Jacques Monod

Hosted by

M. Alexandre BAFFET
Directeur de recherche
Biologie cellulaire et Cancer (UMR144)

Institut Curie

Invited by

Mrs. Renata BASTO
Directrice de Recherche
Biologie cellulaire et Cancer (UMR144)

Institut Curie

Biologie cellulaire et Cancer (UMR144)

Institut Curie


Mrs. Charlotte LOZACH


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