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Séminaire

Vendredi 9 Septembre 2022
10h
Centre de recherche - Paris - Amphithéâtre Constant-Burg - 12 rue Lhomond, Paris 5e

Targeting chromatin regulators in cancer

A hallmark of all malignancies is transcriptional dysregulation, which is initiated by recurrent translocations and/or mutations in transcription factors and chromatin regulators. These genetic aberrations manifests as a block in differentiation and an increase in malignant self-renewal. They also facilitate the cancer’s ability to adapt rapidly to therapeutic pressure. These established features of cancer have led to widespread optimism that therapies against chromatin regulators would dramatically change the natural history of this disease. Whilst early pre-clinical studies with several epigenetic therapies fuelled this optimism, results from early clinical trials have offered a more sobering message. The challenge that lies ahead is getting a complete understanding of the molecular mechanisms that govern how chromatin regulators facilitate the initiation and maintenance of cancer. In addition, an ever-increasing challenge involves defining how chromatin regulators are leveraged to adapt to therapeutic pressure exerted by conventional therapies, targeted therapies, and immunotherapies. In this session, I will focus on the molecular and cellular mechanisms by which chromatin regulators contribute to the establishment of malignant transcription programs that provide fitness to cancer cells. I will also discuss our recent work on how chromatin regulators are co-opted to facilitate therapeutic resistance including evasion of anti-cancer immunesurveillance. I will particularly highlight new epigenetic therapies that have recently been developed and discuss how they maybe more effectively incorporated into clinical practice to improve outcomes for patients with aggressive and often incurable malignancies.

Orateur(s)

Pr Mark Dawson
Professor, Sir Peter MacCallum Department of Oncology & Centre for Cancer Research, University of Melbourne

Professor, Sir Peter MacCallum Department of Oncology & Centre for Cancer Research, University of Melbourne

Organisateur(s)

Dr Raphaël Rodriguez

Invité(e)(s) par

Dr Raphaël Rodriguez
Chimie et Biologie de la Cellule (UMR3666 / U1143)

Institut Curie