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Seminar

Tuesday, June 7th, 2022
11h
Centre de recherche - Paris - Amphithéâtre Marie Curie

Molecular regulation of T cell responses in human cancer

T cells can largely infiltrate human tumors but fail to provide long-term control of cancer growth due to acquired dysfunction and immunosuppression in the tumor microenvironment. We have discovered stem-like T cell populations with capability to mediate superior anti-tumor T cell responses. I will discuss the molecular properties of these cells in relation to dysfunctional mechanisms and immunosuppression by CD4+ regulatory T cells (Treg). In this regard, I will also illustrate novel molecular regulators specifying the Treg identity in cancer.

Speaker(s)

Enrico Lugli

Humanitas Research - Milano, Italy

Invited by

Christina Metoikidou
Immunité et cancer (U932)

Institut Curie

Sebastian Amigorena
Immunité et cancer (U932)

Institut Curie

Learn more

I obtained a PhD in Immunology from the University Modena and Reggio Emilia, Italy, under the supervision of Prof. Andrea Cossarizza where I studied T cell immune responses and homeostasis during the course of Human Immunodeficiency Virus (HIV) infection. I then moved to the Vaccine Research Center at the National Institutes of Health in Bethesda, MD, USA to join the ImmunoTechnology Section directed by Dr. Mario Roederer. There, I studied the molecular mechanisms involved in the maintenance of long-lived T cell immunity in humans and nonhuman primates. In collaboration with Dr. Thomas Waldmann, I moved Interleukin (IL)-15, a cytokine capable of activating anti-tumor effector cells, from the preclinical level to the first-in-human phase I clinical trial in patients with solid cancers. After a brief period as a senior scientist under the supervision of Prof. Domenico Mavilio, I obtained an independent position as the principal investigator of the Laboratory of Translational Immunology and as head of the Humanitas flow cytometry core. My research is funded by a Starting Grant from the European Research Council, the US Cancer Research Institute, the Associazione Italiana per la Ricerca sul Cancro e by the Italian Ministry of Health.