A spatial multiomics atlas of the human lungs reveals a novel IgA immune niche
To better understand lung function and immunity, we have generated a multi-omics single cell, nuclei and Visium Spatial Transcriptomics data set for 5 proximal-to-distal locations of the human lung. Our atlas defines novel cell types/states which we map back into the macro- and micro-anatomical tissue context, including distinct pericyte and smooth muscle subtypes, immune-recruiting fibroblasts, peribronchial and perichondrial fibroblasts, peripheral nerve associated fibroblasts, Schwann cells and submucosal gland (SMG) duct cells. Using our atlas we define a survival niche for IgA secreting plasma cells at the SMG, comprising the newly defined epithelial SMG-Duct cells, along with SMG-Serous cells and B and T lineage immune cells. We propose a signalling circuit that establishes and supports this niche. Our online resource for data browsing, automated cell type annotation and spatial mapping of genes will facilitate the study of tissue microenvironments such as the newly defined gland-associated immune niche.
Dr, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK
CRUK Cambridge Centre - Cancer Research UK Cambridge Institute
Directeur de Recherche CNRS